Pharmaceutical composition for use in the therapeutic treatment of cancer and complications of cancer

A composition and drug technology, applied in the directions of drug combinations, active ingredients of hydroxyl compounds, antipyretics, etc., can solve the problem that targeted therapy does not use effective prognostic biomarkers, etc.

Active Publication Date: 2019-04-02
盖伊福斯汀蒙卡姆尼奇欧
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  • Summary
  • Abstract
  • Description
  • Claims
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AI Technical Summary

Problems solved by technology

[0007] Although biomarkers have been validated for breast cancer (HER copy number), lung cancer (EGFR mutation)

Method used

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Experimental program
Comparison scheme
Effect test

Embodiment

[0069] The following composition percentages are weight percentages relative to the total weight of the active substance.

[0070] Composition 1a: beta-elemene (30%), lupeol (30%) and 2-hydroxycinnamaldehyde (40%).

[0071] Composition 1b: beta-elemene (30%), lupeyl alcohol (30%) and 2'-benzoyloxycinnamaldehyde (40%).

[0072] Composition 2: beta-elemene (30%), lupeol (30%), 2-hydroxycinnamaldehyde (20%) and 2'-benzoyloxycinnamaldehyde (20%).

[0073] Composition 3a: beta-elemene (50%), lupeol (30%) and 2-hydroxycinnamaldehyde (20%).

[0074] Composition 3b: beta-elemene (50%), lupeol (30%) and 2'-benzoyloxycinnamaldehyde (20%).

[0075] Composition 4a: β-elemene (15%), lupeol (50%), β-sitosterol (25%) and 2-hydroxycinnamaldehyde (10%).

[0076] Composition 4b: β-elemene (15%), lupeol (50%), β-sitosterol (25%) and 2'-benzoyloxycinnamaldehyde (10%).

[0077] Composition 5a: β-elemene (20%), lupeol (20%), β-sitosterol (40%) and 2-hydroxycinnamaldehyde (20%).

[0078] Compos...

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Abstract

The invention relates to a pharmaceutical composition, characterized in that it comprises, as an active substance, a combination of beta-elemene, lupeol and a pharmaceutically active agent selected from cinnamaldehyde, 2-hydroxycinnamaldehyde, 2'- benzoyloxycinnamaldehyde, beta-sitosterol, curcumin and the mixtures thereof.

Description

technical field [0001] The present invention relates to pharmaceutical compositions useful as medicaments, in particular for the treatment of cancer, especially hepatocellular carcinoma. Background technique [0002] Effective palliative care of hepatocellular carcinoma (HCC) has long been considered difficult because this type of tumor is often resistant to conventional cytotoxic chemotherapy. Furthermore, aggressive chemotherapy with several nonselective cytotoxic molecules cannot usually be offered to cirrhotic patients with impaired liver function due to the high risk of systemic side effects. [0003] Improved knowledge of the molecular processes involved in tumorigenesis has directed the identification of new targets for the treatment of cancer. Accordingly, new so-called "targeted" therapies are now available in the treatment of HCC and other tumors. They primarily intervene in the transduction of signals (signals that require cell reproduction). The so-called tyro...

Claims

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Application Information

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IPC IPC(8): A61K31/015A61K31/045A61K31/11A61K31/12A61K31/216A61K31/575A61K45/06A61P35/00A61K31/56
CPCA61K45/06A61K31/015A61K31/045A61K31/11A61K31/12A61K31/216A61K31/56A61K31/575A61P35/00A61K2300/00A61P29/00A61P1/04
Inventor 盖伊·福斯汀·蒙卡姆·尼奇欧
Owner 盖伊福斯汀蒙卡姆尼奇欧
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