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Graphene-based nanomaterial for antitumor drug carrier and preparation method of graphene-based nanomaterial

An anti-tumor drug, graphene-based technology, applied in anti-tumor drugs, nanotechnology for materials and surface science, drug combination, etc., can solve the problem of limited research on drug loading

Pending Publication Date: 2019-04-16
JILIN UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0004] Planck F127 is an amphiphilic substance, which is widely used in drug-loading systems, but there are not many studies on GO modified by PF127 and drug-loading

Method used

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  • Graphene-based nanomaterial for antitumor drug carrier and preparation method of graphene-based nanomaterial
  • Graphene-based nanomaterial for antitumor drug carrier and preparation method of graphene-based nanomaterial
  • Graphene-based nanomaterial for antitumor drug carrier and preparation method of graphene-based nanomaterial

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Embodiment

[0032] The experimental conditions and parameters for the preparation of graphene-based nanomaterials for anti-tumor drug carriers are as follows:

[0033] 1) After stirring and dissolving concentrated sulfuric acid (25ml), potassium persulfate (4g), and phosphorus pentoxide (4g), add 4g of graphite, react at a constant temperature for 6 hours, add deionized water (800ml), and let stand for 12 hours; Remove the supernatant, wash the precipitate with deionized water until it is close to neutral, and complete the pre-oxidation of graphite;

[0034] 2) Add concentrated sulfuric acid (50ml), sodium nitrate (1g), and pre-oxidized graphite (1g) into the Erlenmeyer flask. After stirring evenly, add potassium permanganate (4g), and heat up to 60°C in an ultrasonic cleaner. ℃, the power is 80W, stirring for 10 minutes after every 170 minutes of ultrasound, a total of 18 hours; then at room temperature, successively add hydrogen peroxide, 30wt% hydrochloric acid, deionized water, ethano...

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Abstract

The invention provides a graphene-based nanomaterial for an antitumor drug carrier and a preparation method of the graphene-based nanomaterial. The graphene-based nanomaterial is characterized in thatthrough the combination of an X-ray diffractometer, a Fourier transform infrared spectrometer, an atomic force microscope and an ultraviolet spectrophotometer test, it is found that a functionalizedgraphene oxide nanosheet has a lateral dimension less than 200nm and a thickness less than 2nm, drug is successfully supported on the graphene oxide nanosheet, a complex does not aggregate in large area in a cell culture medium and can enter a cell; through the combination of a CCK-8 method and an inverted fluorescence microscope in-vitro detection test, it is shown that a complex solution has a stronger anti-human glioma U251 cell effect. Based on the unique nanostructure and excellent physical and chemical properties and biological properties of the graphene-based nanomaterial, the graphene-based nanomaterial is a potential molecular targeted therapeutic drug.

Description

Technical field: [0001] The invention relates to a functionalized graphene oxide, which has no obvious toxicity to human astrocytes, and exhibits strong apoptosis-promoting effect on human glioma cells by compounding antitumor drugs and graphene-based nanomaterials. Generally speaking, the present invention is to prepare planck PF127 modified graphene oxide and anti-tumor drug doxorubicin hydrochloride homogeneous solution to obtain a potential new anti-tumor therapeutic drug. Background technique: [0002] Glioma is a major disease of the human brain. It is the most common primary tumor of the central nervous system. It has the characteristics of infiltrative growth, high diffusion, and rapid development. Chemotherapy, except for a small number of low-grade gliomas can be cured, most glioma patients are still prone to recurrence after receiving multiple comprehensive treatments, and the prognosis is poor. Although surgery and radiotherapy and chemotherapy techniques have m...

Claims

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Application Information

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IPC IPC(8): A61K47/69A61K31/704A61K47/58A61P35/00B82Y5/00B82Y30/00
CPCA61K31/704A61K47/58A61K47/6923A61P35/00B82Y5/00B82Y30/00
Inventor 王赞邓方王欣王萍悦郭珍妮张亚男孙晴晴
Owner JILIN UNIV
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