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Compound antibacterial aerosol as well as preparation method and application thereof

A compound antibacterial and aerosol technology, applied in aerosol delivery, topical antibacterial agents, anti-inflammatory agents, etc., can solve the problem of single antibacterial effect of sugar antibacterial aerosol, limited application scope and application effect, and unsatisfactory antibacterial effect. and other problems, to achieve the effect of preventing and controlling wound infection, simple production and good sterilization effect

Inactive Publication Date: 2019-04-26
东元科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In the prior art disclosed in the above patents, the antibacterial effect of the sugar antibacterial aerosol is single, and the antibacterial effect is not ideal, and chitosan needs to be dissolved in dilute acetic acid, which can stimulate the human body. Therefore, chitosan antibacterial aerosol The application range and application effect of the aerosol are greatly limited

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] A composite antibacterial aerosol, characterized in that its raw materials include the following components by weight: 17.5 parts of chitosan quaternary ammonium salt, 0.9 parts of emulsifier, 37.1 parts of distilled water, 20.5 parts of propellant, 1.3 parts of sodium chloride , 0.1 parts of potassium chloride, 3.5 parts of dried tea leaves, 1.5 parts of vitamin C, and 1.9 parts of higher fatty acid sodium.

[0024] Vitamin C can be replaced with hydrogen peroxide.

[0025] The emulsifier is gum arabic.

[0026] The concentration of hydrogen peroxide is 5%.

[0027] A preparation method of composite antibacterial aerosol, comprising the following steps:

[0028] S1) Raw material preparation: weigh chitosan quaternary ammonium salt, emulsifier, distilled water, propellant, sodium chloride, potassium chloride, dry tea tree leaves, vitamin C, sodium higher fatty acid according to the formula ratio;

[0029] S2): dry the dried tea leaves and put them into a pulverizer f...

Embodiment 2

[0037] A composite antibacterial aerosol, characterized in that its raw materials include the following components by weight: 19.2 parts of chitosan quaternary ammonium salt, 1.5 parts of emulsifier, 39.3 parts of distilled water, 25.2 parts of propellant, 2.1 parts of sodium chloride , 0.7 parts of potassium chloride, 3.9 parts of dried tea leaves, 1.7 parts of vitamin C, and 2.3 parts of higher fatty acid sodium.

[0038] Vitamin C can be replaced with hydrogen peroxide.

[0039] The emulsifier is soybean lecithin.

[0040] The concentration of hydrogen peroxide is 5%.

[0041] A preparation method of composite antibacterial aerosol, comprising the following steps:

[0042] S1) Raw material preparation: weigh chitosan quaternary ammonium salt, emulsifier, distilled water, propellant, sodium chloride, potassium chloride, dry tea tree leaves, vitamin C, sodium higher fatty acid according to the formula ratio;

[0043] S2): dry the dried tea leaves and put them into a pulver...

Embodiment 3

[0051] A composite antibacterial aerosol, characterized in that its raw materials include the following components by weight: 21.2 parts of chitosan quaternary ammonium salt, 3.5 parts of emulsifier, 45.8 parts of distilled water, 38.2 parts of propellant, 2.8 parts of sodium chloride , potassium chloride 1.1 parts, dried tea leaves 5.7 parts, vitamin C 2.1 parts, higher fatty acid sodium 2.7 parts.

[0052] Vitamin C can be replaced with hydrogen peroxide.

[0053] The emulsifier is one of gum arabic, soybean lecithin or fatty acid glyceride.

[0054] The concentration of hydrogen peroxide is 4%.

[0055] A preparation method of composite antibacterial aerosol, comprising the following steps:

[0056] S1) Raw material preparation: weigh chitosan quaternary ammonium salt, emulsifier, distilled water, propellant, sodium chloride, potassium chloride, dry tea tree leaves, vitamin C, sodium higher fatty acid according to the formula ratio;

[0057] S2): dry the dried tea leaves a...

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PUM

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Abstract

The invention provides a compound antibacterial aerosol. The compound antibacterial aerosol is prepared from the following raw material components: 17.5 to 23.5 parts of chitosan quaternary ammonium salt, 0.9 to 4.7 parts of emulsifier, 37.1 to 54.9 parts of distilled water, 20.5 to 45.9 parts of propellant, 1.3 to 3.5 parts of sodium chloride, 0.1 to 1.2 parts of potassium chloride, 3.5 to 7.5 parts of dry tea leaves, 1.5 to 2.9 parts of vitamin C and 1.9 to 3.1 parts of sodium higher fatty acid; the emulsifier is one of Arabic gum, soybean phospholipid or fatty glyceride; the concentration of hydrogen peroxide is 0.1 to 5 percent; chitosan diquaternary ammonium salt, the vitamin C and sodium chloride all have good antibacterial properties; by combining the three substances to achieve theantibacterial effect of wound, wound infection can be prevented and controlled while antibacterial and anti-inflammatory properties are achieved; the chitosan diquaternary quaternary ammonium salt, the hydrogen peroxide and the sodium chloride have good sterilization effects on the skin surface; the compound antibacterial aerosol has the advantages of simple preparation, short production cycle and environmental friendliness.

Description

technical field [0001] The invention relates to the technical field of aerosols, in particular to a composite antibacterial aerosol. Background technique [0002] Chitosan, a natural polymer, has excellent properties such as biocompatibility, non-toxicity, antibacterial activity, and microbial degradability. The current research on the modification of chitosan is mainly to introduce a quaternary ammonium salt structure on the C2-NH2 group. , this chemically obtained chitosan quaternary ammonium salt has good biocompatibility, not only has good water solubility, antibacterial, film-forming, cationic adsorption, moisture absorption, flocculation and anti- It also has excellent properties such as non-toxic, safe, bactericidal and antibacterial, and biodegradable, and its antibacterial properties are much better than chitosan and other chitosan derivatives. These excellent properties make chitosan double Quaternary ammonium salts are widely used in medicine, bioengineering, foo...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K33/14A61K33/40A61K36/82A61K9/12A61P17/02A61P29/00A61P31/02A61K31/375A61K31/722
CPCA61K9/0014A61K9/0043A61K9/006A61K9/12A61K31/375A61K31/722A61K33/14A61K33/40A61K36/82A61P17/02A61P29/00A61P31/02A61K2300/00
Inventor 王艳磊王秀辉昂正益张婕
Owner 东元科技有限公司
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