Instant type thermotropic hydrogel compound as well as preparation method and application thereof

A hydrogel, instant type technology, applied in the field of medical polymers, can solve the problems of inoperability, increase storage and transportation costs, poor operability, etc., and achieve simple operation and steps, saving transportation costs, and reducing transportation costs. Effect

Inactive Publication Date: 2019-04-26
FUDAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] However, this type of block copolymer is usually a viscous semi-solid at room temperature, and its viscosity is very unfavorable for weighing and pipetting, and its operability is poor, and it usually takes a long time to dissolve in water (12~ 48h), and for a product intended for clinical use, the long preparation period and difficult operation will obviously limit its application prospects
Although the product is prepared into a solution state during factory production, the problem of slow dissolution in clinical application can be avoided to a certain extent, but this increases the time investment of the production enterprise on the one hand, and increases storage and transportation costs on the other hand. Aliphatic polyester-polyether block copolymers are easily hydrolyzed in water, and usually require frozen storage, and cold chain equipment is required for transportation

Method used

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  • Instant type thermotropic hydrogel compound as well as preparation method and application thereof
  • Instant type thermotropic hydrogel compound as well as preparation method and application thereof
  • Instant type thermotropic hydrogel compound as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Instant thermotropic hydrogel complex: 2 g of PEG-PLGA with a molecular weight of 550-900, and 2 g of glucose.

[0037] The preparation method of the above-mentioned instant thermotropic hydrogel complex comprises the following steps:

[0038] Step (1): Weighing 2g of PEG-PLGA with a diblock molecular weight of 550-900 and 2g of glucose respectively;

[0039] Step (2): Put 2 g of PEG-PLGA with a diblock molecular weight of 550-900 and 2 g of glucose in a container, add 18 g of ultrapure water to the container at 4° C., and use magnetic stirring for 12 hours to dissolve to form glucose and PEG- PLGA micelle mixed aqueous solution, for subsequent use;

[0040] Step (3): The mixed solution obtained in step (2) was frozen in liquid nitrogen into a block, and then placed in a freeze dryer. After drying for 24 hours, an instant thermotropic hydrogel complex was obtained.

[0041] Characteristics of the instant thermotropic hydrogel complex: Weigh 4g of the above-prepared in...

Embodiment 2

[0044] Instant thermotropic hydrogel complex: 1 g of PLA-PEG-PLA with a molecular weight of 1750-1000-1500 and 0.5 g of glucose.

[0045] The preparation method of the above-mentioned instant thermotropic hydrogel complex comprises the following steps:

[0046] Step (1): Weigh respectively: 1 g of PLA-PEG-PLA with a molecular weight of 1750-1000-1500 and 0.5 g of glucose;

[0047] Step (2): Place 1g of PLA-PEG-PLA with a block molecular weight of 1750-1500-1750 and 0.5g of glucose in 20g of a mixed solvent composed of tert-butanol and water in a mass ratio of 1:1, and place at 25 ℃ environment, stir magnetically until dissolved and set aside;

[0048] Step (3): The mixture obtained in step (2) was frozen at -20°C into a block, placed in a freeze dryer, and dried for 24 hours to obtain an instant thermotropic hydrogel complex.

[0049]Properties of the instant thermotropic hydrogel complex: the instant thermotropic hydrogel complex is a fluffy solid at room temperature (23-26...

Embodiment 3

[0052] Instant thermotropic hydrogel complex: 1 g of PLGA-PEG-PLGA with a molecular weight of 1500-1000-1500 and 1 g of a molecular weight of 1250-1500-1250, and 1 g of glucose.

[0053] The preparation method of the above-mentioned instant thermotropic hydrogel complex comprises the following steps:

[0054] Step (1): 1 g of PLGA-PEG-PLGA with a block molecular weight of 1500-1000-1500 and 1 g of block molecular weight of 1250-1500-1250 and 1 g of glucose were weighed respectively;

[0055] Step (2): PLGA-PEG-PLGA with a block molecular weight of 1500-1000-1500 and a block molecular weight of 1250-1500-1250 is placed in a container, and 18g of ultrapure water is added to the container at 4°C. Dissolve under magnetic stirring for 12 hours to form a micellar aqueous solution with a concentration of 10%, and set aside;

[0056] Step (3): The crystalline solid is placed in the container containing the micellar aqueous solution in step (2) and continuously stirred at 4° C. for 20...

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Abstract

The invention discloses an instant type thermotropic hydrogel compound. The instant type thermotropic hydrogel compound is prepared from a crystalline solid and polyethylene glycol-aliphatic copolyester, wherein the mass ratio of the crystalline solid to the polyethylene glycol-aliphatic copolyester is (0.5 to 2) to (1 to 2); and the instant type thermotropic hydrogel compound is obtained by dissolving a thermotropic hydrogel type solution and a crystallizable substance jointly in solvent such water and mixing, freezing and drying. The solid-state thermotropic hydrogel compound prepared by a preparation method involved in the invention has an instant property and can be stored and used at a dry state, so that the solid-state thermotropic hydrogel compound does not need to be frozen and stored in a transportation process and the transportation cost is saved.

Description

technical field [0001] The invention relates to the technical field of medical polymers, in particular to an instant thermotropic hydrogel compound and its preparation method and application. Background technique [0002] Thermotropic hydrogels are generally a class of special materials composed of high molecular weight polymers and water, whose physical state is responsive to temperature changes, exhibiting a sol-to-gel state change. At present, in the medical and health field, thermally induced hydraulic coagulation composed of polyester-polyether block copolymers has attracted people's attention, for example, there is a class composed of poly(lactic-co-glycolic acid) The concentrated solution formed after the block copolymer is dissolved in water is an injectable aqueous solution at room temperature, and can be transformed into a gel state as the temperature rises, which has a very wide application prospect. For example, in the field of preventing postoperative adhesions...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L31/14A61K9/06A61K47/34A61K47/26C08J3/075C08L67/00
CPCA61K9/06A61K47/26A61K47/34A61L31/06A61L31/14A61L31/145C08J3/075C08J2367/00C08L67/00
Inventor 丁建东唐敬玉蔡彩云俞麟
Owner FUDAN UNIV
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