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Vitamin A powder, tablets and preparation method

A technology for vitamins and powders, which can be used in pill delivery, powder delivery, pharmaceutical formulations, etc. It can solve the problems of high cost and limited effect of anti-oxidation improvement, and achieve the effect of improving anti-oxidation, improving stability, and good dispersion

Inactive Publication Date: 2019-05-03
MINNAN NORMAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The spray drying method has certain restrictions on the encapsulation reagents, which must have a certain solubility in water, and there are problems such as the need for special electrical equipment.
[0018] (2) The spray cooling method is similar to the spray drying method, and there are certain restrictions on the packaging reagents, and special electrical equipment is also required
[0019] (3) There are relatively few systems used in the coagulation method at present, and the gelatin-gum arabic system is the most commonly used, and new systems and suitable solvents need to be developed
[0020] (4) The liposome method and the inclusion method are used only to encapsulate vitamins with liposomes or cyclodextrins, which is more expensive, or the effect of improving antioxidant activity is limited

Method used

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  • Vitamin A powder, tablets and preparation method

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preparation example Construction

[0056] like figure 1 Shown, the preparation method of the vitamin A powder that the embodiment of the present invention provides comprises:

[0057] S101, dissolve β-cyclodextrin (β-CD) or hydroxypropyl-β-cyclodextrin (HP-β-CD) in an appropriate amount of ethanol (8.0-12mL / g), and magnetically stir until completely dissolved.

[0058] S102. Weigh a certain amount of vitamin A palmitate (the molar ratio of vitamin ester to cyclodextrin is 0.1-1), stir with an appropriate amount of ethanol (25-40 mL / g) until completely dissolved.

[0059] S103, evenly drop the vitamin A palmitate solution into the cyclodextrin solution (0.5-1 hour), make the two fully mixed, and avoid light during the mixing process.

[0060] S104, take an appropriate amount of carrageenan and moisten it with ethanol, then add distilled water, slowly add the carrageenan colloid into the inclusion solution of cyclodextrin and vitamin A palmitate, and continue stirring for 0.5-1 hour.

[0061] S105, weigh an app...

Embodiment

[0065] Weigh 1g of 2-hydroxypropyl-β-cyclodextrin, add 8.0mL ethanol to dissolve; weigh 0.34g vitamin A palmitate, add 12.0mL ethanol and stir until completely dissolved. Drop the dissolved vitamin A palmitate solution into the 2-hydroxypropyl-β-cyclodextrin solution, stir and mix thoroughly. Take 1.0g of carrageenan and wet it with 2.0mL of ethanol, add 8.0mL of distilled water, slowly add the stirred carrageenan colloid into the mixed solution of vitamin A palmitate and 2-hydroxypropyl-β-cyclodextrin, and continue stirring 30min. Weigh 0.340g of maltodextrin, stir and dissolve with 5.0mL of distilled water. Quickly add the dissolved maltodextrin to the mixture of 2-hydroxypropyl-β-cyclodextrin, carrageenan and vitamin A palmitate, stir and cool in an ice-water bath, filter to obtain solid powder, vacuum at 40°C Dried in a drying oven to obtain solid powder of vitamin A palmitate, the product is pale yellow. The solid powder is placed in a mold and pressed into tablets to ...

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Abstract

The invention belongs to the technical field of nutrient healthcare products and discloses vitamin A powder, tablets and a preparation method. An inclusion method and a coagulation method are combined, vitamin A ester is included by cyclodextrin firstly to improve water solubility and oxidation resistance of the vitamin A ester, and then, carrageenan and maltodextrin are added to be coagulated andseparated out with an inclusion complex, so that the vitamin A powder is prepared and tableted into tablets conveniently. No special electrical equipment is required, the stability of the vitamin A ester is improved by secondary coating of the vitamin A ester, the product has good dispersity in water and can be applied to food enhancers and prepared into tablets, and a new way for preparing oraltablets.

Description

technical field [0001] The invention belongs to the technical field of nutraceuticals, and in particular relates to a vitamin A powder and tablet and a preparation method. Background technique [0002] At present, the existing technologies commonly used in the industry are as follows: [0003] Vitamins are important nutritional and health-care medicines. They are low-molecular-weight organic compounds that maintain normal physiological functions of the human body. They are required in small quantities but have great effects. They cannot be synthesized in the body or are not synthesized in sufficient quantities, so they need to be supplemented from food and medicine. Vitamins can be divided into fat-soluble and water-soluble two categories. Fat-soluble vitamins include vitamin A, vitamin D, vitamin E, and vitamin K; water-soluble vitamins include B vitamins and vitamin C. [0004] Vitamin A was the first fat-soluble vitamin to be recognized and discovered. It can not only ...

Claims

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Application Information

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IPC IPC(8): A61K9/14A61K9/20A61K47/69A61K47/36A61K31/232A61K31/07A61P17/02A61P17/00A61P27/02A61P11/00A61P27/16A61P1/00A61P3/06A61P9/10A23L33/155A23P10/47A23P10/28A23L29/30A23L29/256
Inventor 姚碧霞翁文
Owner MINNAN NORMAL UNIV
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