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Identification method of miRNA functional module and system thereof

A technology of functional modules and identification methods, applied in the field of information biology

Inactive Publication Date: 2019-05-03
HUNAN CITY UNIV
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although various methods have been used to predict the association between miRNA and disease, however, how to effectively discover the association between miRNA and disease is still a major challenge in bioinformatics

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  • Identification method of miRNA functional module and system thereof
  • Identification method of miRNA functional module and system thereof
  • Identification method of miRNA functional module and system thereof

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Embodiment Construction

[0059] The following will clearly and completely describe the technical solutions in the embodiments of the present invention with reference to the accompanying drawings in the embodiments of the present invention. Obviously, the described embodiments are only some, not all, embodiments of the present invention. Based on the embodiments of the present invention, all other embodiments obtained by persons of ordinary skill in the art without making creative efforts belong to the protection scope of the present invention.

[0060] In order to make the above objects, features and advantages of the present invention more comprehensible, the present invention will be further described in detail below in conjunction with the accompanying drawings and specific embodiments.

[0061] figure 1 It is a schematic flowchart of the method for identifying miRNA functional modules of the present invention. Such as figure 1 As shown, the identification method includes the following steps:

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Abstract

The invention discloses an identification method of a miRNA functional module and a system thereof. The identification method comprises the steps of acquiring a to-be-analyzed miRNA database; calculating similarity between two random miRNAs, and obtaining the similarity between two random miRNAs; constructing an undirected graph of the miRNA; wherein the summits in the undirected graph are to-be-analyzed miRNAs, and the weight of the side between two adjacent summits is the similarity between two different miRNAs which correspond with the two summits; obtaining a target function in which density is used as an evolution plan; by means of a single-target genetic algorithm, using a highest value of the target function as a target, and obtaining all un-allocated sub-graph of the undirected graph; and determining all un-allocated sub-graphs as the identified miRNA functional modules. The identification method and the system thereof are advantages in that simple realization is obtained; thedensity is used as the target function for identifying the miRNA functional module, thereby supplying valuable clues for medical diagnosis.

Description

technical field [0001] The invention relates to the field of information biology, in particular to a method and system for identifying miRNA functional modules. Background technique [0002] miRNAs (microRNAs) are a class of evolutionarily conserved non-coding small molecule RNAs that can regulate gene expression at the translational level, and therefore play a very important role in some biological pathways related to diseases. Although the functional roles of miRNAs in specific biological processes have been discovered and verified, however, the regulatory mechanisms and functions of most miRNAs are still unknown. With the increase of biological data, more and more miRNAs have been discovered by humans to regulate their functions, revealing the potential relationship between miRNAs and diseases. Because miRNAs perform their functions through their regulated target genes, many computational methods for exploring miRNA functions based on target genes have emerged in recent ...

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G16B20/00G06N3/12
Inventor 曹步文邓曙光阳王东
Owner HUNAN CITY UNIV
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