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A fixed zirconium silane interface modified polyvinylidene fluoride film and its preparation and application

A technology of polyvinylidene fluoride membrane and polyvinylidene fluoride, which is applied in the field of phosphorus-containing protein separation membrane and its preparation and application, can solve the problem of low efficiency of fixed metal chelation affinity technology, low specific adsorption capacity, and inability to repeat Repeated adsorption and other problems to achieve the effect of avoiding phosphorylation process, excellent adsorption effect, and improving affinity

Active Publication Date: 2021-11-09
DONGHUA UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] The technical problem to be solved by the present invention is to provide a fixed zirconium silane interface modified polyvinylidene fluoride membrane and its preparation and application, to overcome the high risk of using the traditional fixed metal chelate affinity microsphere phosphorylation process in the prior art Drugs, and its mechanical properties are poor, it cannot be repeatedly adsorbed repeatedly, the cost is high, the efficiency is slow, and the specific adsorption capacity is not high.
[0010] The invention adopts thermally induced phase separation and silane interface crosslinking technology, which effectively solves the problems of low efficiency and high cost of fixed metal chelation affinity technology, improves the specific adsorption of phosphoproteins, and improves the safety of the experiment , the application prospect is broad

Method used

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  • A fixed zirconium silane interface modified polyvinylidene fluoride film and its preparation and application
  • A fixed zirconium silane interface modified polyvinylidene fluoride film and its preparation and application
  • A fixed zirconium silane interface modified polyvinylidene fluoride film and its preparation and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] (1) Completely dissolve PVDF in triethyl phosphate (TEP) to form a PVDF solution with a mass fraction of 18%. After dissolving at 60°C for 8 hours, the casting solution is left to stand for 10 hours and poured on a 50°C scraper Squeeze the film with a 300 μm scraper, then put it into a mixture of TEP and water at a mass ratio of 1:1 and a temperature of 25°C for 5 seconds, then put it in pure water for 20 hours, and then peel it off to obtain PVDF membrane.

[0044] (2) Dissolve 2g of vinyl phosphoric acid (VPA), 1g of silane coupling agent vinyltriethoxysilane (VTES) and 0.05g of initiator azobisisobutyronitrile (AIBN) in 100g of triethyl phosphate at 60°C In the fusion solution of 1:1 (mass ratio) with water, polymerize for 12h, then immerse the PVDF membrane in the solution for 3h in step (1), and the prepolymer diffuses into the membrane during the immersion in the solution to obtain PVDF / VPA-g-VTES membrane.

[0045] (3) Submerge the PVDF / VPA-g-VTES membrane in ...

Embodiment 2

[0047] (1) Completely dissolve PVDF in triethyl phosphate (TEP) to form a PVDF solution with a mass fraction of 18%. After dissolving at 65°C for 8 hours, the casting solution is left to stand for 10 hours and poured on a 60°C scraper Squeeze the film with a 300 μm scraper, then put it into a mixture of TEP and water at a mass ratio of 1:1 and a temperature of 25°C for 5 seconds, then put it in pure water for 24 hours, and then peel it off to obtain PVDF membrane.

[0048] (2) Dissolve 2.5g vinyl phosphoric acid (VPA), 1.5g silane coupling agent vinyltriethoxysilane (VTES) and 0.06g initiator azobisisobutyronitrile (AIBN) in 100g phosphoric acid tris at 65°C In the fusion solution of ethyl ester and water 1:1 (mass ratio), polymerize for 16h, then immerse the PVDF membrane in the solution for 3h in the step (1), and the prepolymer diffuses into the membrane during the immersion in the solution, and obtains PVDF / VPA-g-VTES membrane.

[0049] (3) Submerge the PVDF / VPA-g-VTES m...

Embodiment 3

[0051] (1) Completely dissolve PVDF in triethyl phosphate (TEP) to form a PVDF solution with a mass fraction of 15%, dissolve it at 70°C for 9 hours, then let the casting solution stand for 10 hours and pour it on a 60°C scraping plate , use a 500μm scraper to scrape the film, then put it into a mixture of TEP and water with a mass ratio of 2:1 and a temperature of 25°C for 5s, then put it in pure water for 24h, and then peel it off to obtain PVDF membrane.

[0052] (2) Dissolve 2.5g vinyl phosphoric acid (VPA), 1.5g silane coupling agent vinyltriethoxysilane (VTES) and 0.06g initiator azobisisobutyronitrile (AIBN) in 100g phosphoric acid tris at 70°C In the fusion solution of ethyl ester and water 1:1 (mass ratio), polymerize for 24h, then immerse the PVDF membrane in the solution for 3h in the step (1), and the prepolymer diffuses into the membrane during the immersion in the solution, and obtains PVDF / VPA-g-VTES membrane.

[0053] (3) Submerge the PVDF / VPA-g-VTES membrane...

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Abstract

The invention relates to a fixed zirconium silane interface modified polyvinylidene fluoride film and its preparation and application. The membrane is obtained by immobilizing metal zirconium on a PVDF membrane modified by vinylphosphoric acid / vinyltriethoxysilane. The preparation method comprises: preparation of PVDF film, preparation of PVDF / VPA-g-VTES film, preparation of fixed zirconium silane interface modified polyvinylidene fluoride film. The membrane not only has an excellent adsorption effect on specific proteins, but also improves separation efficiency and reduces production costs.

Description

technical field [0001] The invention belongs to the field of phosphorus-containing protein separation membranes and their preparation and application, in particular to a fixed zirconium silane interface modified polyvinylidene fluoride membrane and its preparation method and application. Background technique [0002] Due to its excellent physical and chemical properties (strength and corrosion resistance), PVDF can be used as an excellent substrate for protein separation membranes. Combining with immobilized metal chelation affinity chromatography technology, it can not only improve the physical properties of the membrane and facilitate the improvement performance, thus improving production efficiency and separation effect. Immobilized Metal-chelated Affinity Chromatography (IMAC) is a new type of affinity chromatography that has emerged in recent years and is mainly used for the separation of biological macromolecules. In 1975, Paroth proposed this technology, which attrac...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D71/34B01D67/00B01J20/26C07K14/77C07K1/14B01J20/30
Inventor 孙俊芬张逸飞陈龙
Owner DONGHUA UNIV
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