A kind of erythromycin ethylsuccinate granules and preparation method thereof

A technology of erythromycin ethylsuccinate and granules, which is applied in the field of erythromycin ethylsuccinate granules and its preparation, and can solve the problems of reducing the type and amount of excipients, poor dissolution rate, etc.

Active Publication Date: 2021-03-16
河北君临药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The tablet overcomes the disadvantages of ordinary chewable tablets, and reduces the types and dosage of excipients in erythromycin ethylsuccinate chewable tablets. The pharmaceutical preparation has excellent performance and high bioavailability, but the dissolution rate of the tablet is poor

Method used

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  • A kind of erythromycin ethylsuccinate granules and preparation method thereof
  • A kind of erythromycin ethylsuccinate granules and preparation method thereof
  • A kind of erythromycin ethylsuccinate granules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1: erythromycin ethylsuccinate particles

[0042] Prescription composition (25,000 bags):

[0043]

[0044] Preparation:

[0045] ① Pretreatment of raw and auxiliary materials: crush erythromycin ethylsuccinate and white sugar, pass through an 80-mesh sieve, and set aside; dissolve sodium bicarbonate with 1.43 times 90°C water (100ml) to obtain sodium bicarbonate solution; sodium bicarbonate solution, spit Wen-80 was added to the wetting agent to obtain A solution;

[0046] ② Mix raw and auxiliary materials: add erythromycin ethylsuccinate and white sugar into the mixer, stir and mix for 15 minutes at a stirring speed of 15 rpm to obtain mixed powder B;

[0047]③Preparation of soft material granulation: Add the solution A prepared in step ① into the mixed powder B, stir and mix for 15 minutes at a stirring speed of 15 rpm to prepare soft material; take the prepared soft material and pass it through a 20-mesh sieve to granulate ;

[0048] ④ Drying: Dry ...

Embodiment 2

[0052] Embodiment 2: erythromycin ethylsuccinate particles

[0053] Prescription composition (25,000 bags):

[0054]

[0055] Preparation:

[0056] ①Pretreatment of raw and auxiliary materials: crush erythromycin ethylsuccinate and white sugar, pass through an 80-mesh sieve, and set aside; dissolve sodium bicarbonate with 1.4 times 90°C water (101ml) to obtain sodium bicarbonate solution; sodium bicarbonate solution, spit Wen-80 was added to the wetting agent to obtain A solution;

[0057] ② Mix raw and auxiliary materials: add erythromycin ethylsuccinate and white sugar into the mixer, stir and mix for 15 minutes at a stirring speed of 15 rpm to obtain mixed powder B;

[0058] ③Preparation of soft material granulation: Add the solution A prepared in step ① into the mixed powder B, stir and mix for 15 minutes at a stirring speed of 15 rpm to prepare soft material; take the prepared soft material and pass it through a 20-mesh sieve to granulate ;

[0059] ④ Drying: Dry t...

Embodiment 3

[0063] Embodiment 3: erythromycin ethylsuccinate particles

[0064] Prescription composition (25,000 bags):

[0065]

[0066] Preparation:

[0067] ①Pretreatment of raw and auxiliary materials: crush erythromycin ethylsuccinate and white sugar, pass through an 80-mesh sieve, and set aside; dissolve sodium bicarbonate with 1.5 times 80°C water (86ml) to obtain sodium bicarbonate solution; sodium bicarbonate solution, spit Wen-80 was added to the wetting agent to obtain A solution;

[0068] ② Mix raw and auxiliary materials: add erythromycin ethylsuccinate and white sugar into the mixer, stir and mix for 15 minutes at a stirring speed of 15 rpm to obtain mixed powder B;

[0069] ③Preparation of soft material granulation: Add the solution A prepared in step ① into the mixed powder B, stir and mix for 15 minutes at a stirring speed of 15 rpm to prepare soft material; take the prepared soft material and pass it through a 20-mesh sieve to granulate ;

[0070] ④ Drying: Dry th...

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Abstract

The invention provides an erythromycin ethylsuccinate granule and a preparation method thereof. The erythromycin ethylsuccinate granule comprises the following components in parts by weight: 10 partsof erythromycin ethylsuccinate, 176-200 parts of white granulated sugar, 0.20-0.24 part of sodium hydrogencarbonate, 0.5-0.8 part of Tween-80, 15-18 parts of a wetting agent, and 0.7-0.9 part of an essence. By controlling the concentration of the wetting agent and the amount of Tween 80 added, the dissolution rate of the prepared erythromycin ethylsuccinate granule meets the requirements, and thequality of the drug is stable, thereby further ensuring the quality of the erythromycin ethylsuccinate granule and the play of the efficacy.

Description

technical field [0001] The invention relates to the field of pharmaceutical preparations, in particular to a erythromycin ethylsuccinate granule and a preparation method thereof. Background technique [0002] Erythromycin ethyl succinate, ethyl succinate of erythromycin, Chinese aliases: erythromycin ethyl succinate, erythromycin succinate, ethyl succinate erythromycin, ethyl succinate erythromycin, commonly used pharmaceutical preparations There are granules, tablets, capsules, etc. [0003] Erythromycin ethylsuccinate is a macrolide antibiotic, which is more stable in gastric acid than erythromycin. It has antibacterial activity against Staphylococcus genus (except for methicillin-resistant strains), various groups of streptococci and Gram-positive bacilli, and is often used as an alternative drug for those who are allergic to penicillin. It has a good effect on the treatment of Mycoplasma pneumonia, neonatal conjunctivitis, infant pneumonia, Legionnaires' disease, and g...

Claims

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Application Information

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Patent Type & AuthorityPatents(China)
IPC IPC(8): A61K9/16A61K47/26A61K31/7048A61P31/04
Inventor李新联冯朝郭峰张丽娟王红杰王朝辉
Owner河北君临药业有限公司