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Traditional Chinese medicine granule flavoring agent

A technology of traditional Chinese medicine granules and flavoring agents, which is applied in pharmaceutical formulations, medical preparations with inactive ingredients, and inorganic inactive ingredients, etc., can solve the problems of inability to relieve oral bitterness, large difference in taste, and poor flavor correction effect, and achieves Improve the effect of flavor correction, increase the flavor, reduce the effect of feeling

Inactive Publication Date: 2019-06-18
CHANGZHOU SIYU ENVIRONMENTAL PROTECTION MATERIAL SCI & TECH
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Problems solved by technology

[0005] The technical problem to be solved by the present invention: Aiming at the problems that the current traditional Chinese medicine correctives have large taste differences, cannot relieve the bitterness retained in the oral cavity, and have poor taste corrective effects, the present invention provides a traditional Chinese medicine granule corrective

Method used

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  • Traditional Chinese medicine granule flavoring agent

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preparation example Construction

[0026] The preparation method of modified polymer is:

[0027] (1) Put polyethylene glycol and tetrahydrofuran into the reactor at a mass ratio of 1:7-9, preheat at 50-60°C for 40 minutes, then add a compound of 60-70% polyethylene glycol mass and Caprolactone with 20-30% polyethylene glycol mass, protected by nitrogen, heated to 100-105°C, and stirred for 5 hours;

[0028] (2) After stirring, add acetaminophen with 2-5% polyethylene glycol mass, polyglutamic acid with 50-53% polyethylene glycol mass and 2-4% polyethylene glycol mass Mix ethylenediamine evenly, increase the pressure to 1.5MPa, keep warm for 4-6 hours, discharge, freeze-dry, wash with ethanol solution, and dry to obtain the modified polymer.

[0029] The compound is formed by mixing succinic acid and lactic acid in a mass ratio of 5-7:6.

[0030] The additive is made by mixing alkyl glucoside and amino acid at a mass ratio of 4-6:1.

[0031] The mixed solvent is composed of calcium chloride solution and etha...

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Abstract

The invention relates to a traditional Chinese medicine granule flavoring agent and belongs to the technical field of medicinal additives. Firstly, polyethylene glycol is used as a raw material and polymerized with lactic acid and succinic acid under the action of paracetamol to form a block polymer, the block polymer is crosslinked with polyglutamic acid under the action of ethylenediamine, contact between the taste bud with traditional Chinese medicines is blocked, beneficial nutrients are formed by degradation, and no harm is caused to the human body; next, alkyl glycoside is well combinedwith mucin in the oral cavity, combination on the tongue is improved, the film forming property is increased, the feeling to traditional Chinese medicines is further reduced, meanwhile, extraction isperformed on pomegranate rind and clove bulbs, on one hand, essential oil is obtained by extraction, the fragrance of the essential oil is used for covering, the fragrance is increased, on the other hand, tannin is obtained and can be combined with alkaloid in the traditional Chinese medicines to reduce bitterness, and the flavoring effect can be further improved by other aids.

Description

technical field [0001] The invention relates to a traditional Chinese medicine granule flavoring agent, which belongs to the technical field of medicinal additives. Background technique [0002] The taste of medicines can affect patients' compliance with taking medicines. For drugs with poor taste, flavoring agents are often added in the formulation development process to cover up the bad taste. And these correctives have no therapeutic effect for patients, and for special patients, there may also be some side effects. It is also found in clinical practice that some people have a strong tolerance for bad taste, and they think that they do not need the help of flavoring agents, and taking too much flavoring agents will increase the burden on the body. There are also some people who have a unique perception of taste. These people often cannot accept a certain taste, and even cause vomiting. This specific taste may come from flavoring agents. Therefore, adding correctives in...

Claims

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Application Information

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IPC IPC(8): A61K9/16A61K47/46A61K47/34A61K47/10A61K47/26A61K47/02
Inventor 黄名名
Owner CHANGZHOU SIYU ENVIRONMENTAL PROTECTION MATERIAL SCI & TECH
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