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A kind of method utilizing Abamectin crystal mother liquor to extract Abamectin b2a

A technology of abamectin and crystallization mother liquor, applied in the directions of chemical instruments and methods, organic chemistry, sugar derivatives, etc., can solve the problems of increased environmental pollution index, long production cycle and high production cost, and achieves good extraction effect, The effect of improving utilization rate and high extraction yield

Active Publication Date: 2022-04-26
NINGXIA TAIYICIN BIOTECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This technology uses tetrabutylammonium bromide aqueous solution for washing, which has better impurity removal effect than traditional water washing or saturated brine washing, and the solution is easier to layer, which improves the purity of abamectin B2a to a certain extent, but uses carcinogens Aromatic hydrocarbons are used as crystallization and recrystallization solvents, safety cannot be guaranteed, the environmental pollution index increases, and the two crystallization methods at the same time lead to a long production cycle and relatively high production costs

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] Abamectin crystallization mother liquor 10L, the concentration content of Abamectin B2a is 31.2% after testing. Concentrate under reduced pressure until no liquid flows out (remove the solvent) to obtain 3.2kg of solid matter; add 19.2L of triethylene glycol-methyl ether to the solid matter, stir and dissolve at 40°C, and obtain abamectin after filtration Solution 19.2lL. Add 64 g of silica gel decolorizing sand to the abamectin solution, stir for 80 min, and filter. Add purified water to the avermectin solution obtained by filtration, cool and crystallize, and the temperature of the mixed solution drops from the initial 40°C to 0°C. The cooling rate is controlled at 2-3°C / h. During the cooling process, the initial stirring speed is controlled at 50r / min; when the temperature drops to 25°C, the stirring speed is controlled at 35r / min; when the temperature drops to 10°C, the stirring speed is controlled at 20r / min; when the temperature drops to 0°C, the stirring speed ...

Embodiment 2

[0036]Abamectin crystallization mother liquor 10L, the concentration content of Abamectin B2a is 33.1% after testing. Concentrate under reduced pressure until no liquid flows out (remove the solvent) to obtain 3.5kg of solid matter; add 22.8L of triethylene glycol-ethyl ether to the solid matter, stir and dissolve at 45°C, and obtain abamectin solution after filtration 22.8lL. Add 88 g of silica gel decolorizing sand to the abamectin solution, stir for 85 min, and filter. Add purified water to the avermectin solution obtained by filtration, cool and crystallize, and the temperature of the mixed solution drops from the initial 45°C to -1°C. The cooling rate is controlled at 2-3°C / h. During the cooling process, the initial stirring speed was controlled at 52r / min; when the temperature dropped to 24°C, the stirring speed was controlled at 34r / min; when the temperature dropped to 9°C, the stirring speed was controlled at 19r / min; when the temperature dropped to -1°C, the stirrin...

Embodiment 3

[0038] Abamectin crystallization mother liquor 10L, the concentration content of Abamectin B2a is 35.6% after testing. Concentrate under reduced pressure until no liquid flows out (remove the solvent) to obtain 3.8kg of solid matter; add 26.6L of triethylene glycol-methyl ether to the solid matter, stir and dissolve at 50°C, and obtain abamectin after filtration Solution 26.6L. Add 114g of silica gel decolorizing sand to the avermectin solution, stir for 90min, and filter. Add purified water to the avermectin solution obtained by filtration, cool and crystallize, and the temperature of the mixed solution drops from the initial 50°C to -2°C. The cooling rate is controlled at 2-3°C / h. During the cooling process, the initial stirring speed was controlled at 55r / min; when the temperature dropped to 23°C, the stirring speed was controlled at 33r / min; when the temperature dropped to 8°C, the stirring speed was controlled at 17r / min; when the temperature dropped to -2°C, the stirri...

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PUM

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Abstract

The invention relates to a method for extracting abamectin B2a by using the abamectin crystallization mother liquor. The process steps are: concentrating the abamectin crystallization mother liquor under reduced pressure, removing the solvent to obtain a solid, and then adding triethylene glycol Alcohol-methyl ether or triethylene glycol-diethyl ether, stirred and dissolved at 40°C to 60°C, filtered to obtain abamectin solution, decolorized, filtered, cooled and crystallized, left to stand, filtered, and dried to obtain Abamectin B2a. The present invention can make the effective content of avermectin B2a reach 97-98%, the extraction yield reaches 96-98%, and the whole extraction process is simple, the process flow is easy to control, a single crystallization method is adopted, and repeated crystallization is avoided technology, the production cost is low, for further improving the utilization rate of abamectin B2a, it provides technical guarantee for its industrialization.

Description

technical field [0001] The invention belongs to the technical field of antibiotic extraction, in particular to a method for extracting abamectin B2a by using abamectin crystallization mother liquor. Background technique [0002] Abamectin, the English name Avermectins, is a class of sixteen-membered macrolide compounds with insecticidal, acaricidal, and nematicidal activities first developed by Satoshi Omura of Kitasato University in Japan and Merck Corporation of the United States. It was produced from Streptomyces Produced by fermentation of Streptomyces avermitilis. There are 8 components in natural Avermectins, mainly 4 kinds, namely A1a, A2a, B1a and B2a, whose total content is ≥80%; Content ≤ 20%. [0003] Abamectin B2 includes two main components, B2a and B2b. The national standard GB19336-2007 of Abamectin original drug targets B2, a mixture of B2a+B2b, without separate separation; The content exceeds 90%, B2b trace. The overall toxicity of B2 is moderately toxic...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07H17/08C07H1/06
Inventor 任勇张萍
Owner NINGXIA TAIYICIN BIOTECH CO LTD