Biomimetic moisturizing model and assessment method thereof

A model and bionic technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve problems such as difficulty in building models, individual differences in experiments, difficult operation time cycles, unsuitable moisturizing systems, etc., to achieve rapid and accurate evaluation and reduce work , Reduce the effect of large fluctuations in data

Active Publication Date: 2019-07-05
GUANGDONG SHUNFENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the objective evaluation method also has its application limitations, because it is difficult to construct various expected models and problems such as individual differences, experimental difficulty, operation time period, etc., making it not suitable for the experimental research of moisturizing system screening, but more suitable for In the test evaluation as a sample

Method used

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  • Biomimetic moisturizing model and assessment method thereof
  • Biomimetic moisturizing model and assessment method thereof
  • Biomimetic moisturizing model and assessment method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] Embodiment 1: Construction of the bionic moisturizing model and its evaluation method according to the present invention

[0024] 1. Preparation of infiltrating moisturizer

[0025] According to the following mass percentages, weigh each component respectively:

[0026]

[0027] Take purified water, add sodium hyaluronate, heat and stir until it is completely dissolved; then add betaine, heat and stir until it is completely dissolved; after cooling down to room temperature, add sodium pyrrolidone carboxylate, and stir evenly to obtain the infiltration moisturizer .

[0028] 2. The test layer is treated with an infiltration moisturizer

[0029] Take several pieces of circular rapid quantitative filter paper with a diameter of 3-4cm, and place them in a circular container with an inner diameter of 3-4cm respectively. After each filter paper is infiltrated with 2.0g of infiltration and humectant, take it out and weigh it accurately, and record it as M 0 , and then pu...

Embodiment 2

[0046] Example 2: Evaluation of moisturizing agent

[0047] 1. Preparation of moisturizer

[0048] According to the formula shown in the following table 1, each component was weighed respectively:

[0049] The formula of table 1 humectant

[0050]

[0051] Preparation of moisturizing agent 1: Take glycerin, add sodium hyaluronate, stir evenly, add purified water, heat and stir until completely dissolved; then add serine, heat and stir until completely dissolved, cool to room temperature, and obtain.

[0052] Preparation of moisturizing agent 2: Take purified water, add sodium hyaluronate, heat and stir until completely dissolved; then add betaine and serine, heat and stir until completely dissolved, cool to room temperature, and obtain.

[0053] Preparation of moisturizing agent 3: Take purified water, add sodium hyaluronate, heat and stir until completely dissolved; then add sodium pyrrolidone carboxylate and serine, heat and stir until completely dissolved, cool to room...

Embodiment 3

[0059] Embodiment three: evaluation of cream

[0060] 1. Preparation of cream

[0061] According to the formula shown in the following table 3, each component was weighed respectively:

[0062] The formula of table 3 cream

[0063]

[0064]

[0065] Preparation of cream:

[0066] ① Take caprylic / capric triglyceride, grape seed oil, polydimethylsiloxane, cetearyl alcohol cetearyl alcohol, cetearyl glucoside, 2,6-di-tert-butyl p- Cresol, stir and heat to about 100°C to dissolve it completely, keep it warm for 15 minutes, stir and cool down to about 75±2°C, set aside;

[0067] ② Take purified water, add glycerin, allantoin, sodium stearyl glutamate, and disodium EDTA, stir and heat to about 75±2°C, then add the solution prepared in item "①", stir and emulsify for 10 minutes;

[0068] ③Stir and cool down to about 45±2°C, add phenoxyethanol under stirring, continue stirring for 5 minutes, turn on the homogenizer for 5 minutes, stir and cool down to below 38°C, and dischar...

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Abstract

The invention discloses a biomimetic moisturizing model and an assessment method thereof. The biomimetic moisturizing model comprises an incubator, a water tank placed in the incubator and a biomimetic membrane module placed above the water tank, wherein the biomimetic membrane module comprises a test layer and a biomimetic membrane. The biomimetic moisturizing model of the invention can simulatethe skin of a living body, has a moisturizing effect test conclusion consistent with that of a skin model of the living body, can quantitatively evaluate a product to be tested, can be used for studying the influences of different components on the moisturizing effect and quantifying assess the moisturizing effect, provides a data support for formula design of skin moisturizing products, is applied to guide formula screening, and provides a faster screening method and theoretical support for product design.

Description

technical field [0001] The invention relates to a bionic moisturizing model and an evaluation method thereof, belonging to the technical field of cosmetics. Background technique [0002] Skin moisturizing is the most basic function of skin care cosmetics and skin care products. The so-called moisturizing is to maintain the moisture in the skin by preventing the moisture loss in the skin and absorbing the moisture in the external environment. With the wide use of various moisturizing cosmetics, how to objectively evaluate and design the moisturizing properties of cosmetics has become an urgent problem for formulation engineers to solve. At present, there are mainly human subjective evaluation method and objective evaluation method for the evaluation of skin moisturizing function. The subjective evaluation method requires evaluators to have considerable experience, and has poor repeatability and low accuracy; the objective evaluation method is mainly based on TEWL (transepid...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): G01N5/02
CPCG01N5/025
Inventor 王北明龚俊瑞严高剑柴将红张超余良钟梁勇坤
Owner GUANGDONG SHUNFENG PHARMA
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