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Microfluid control chip and system

A technology for controlling chips and microfluidics, applied in laboratory utensils, laboratory containers, chemical instruments and methods, etc., can solve the problems of difficulty in guaranteeing liquid dispensing accuracy and rising errors, and achieve simple structure, simple operation process, high-resolution effects

Pending Publication Date: 2019-07-23
徐州昊洋生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

For this working method, when pipetting a small amount of liquid, for example, when the volume of the liquid to be pipetted is less than 1 microliter, the error will increase sharply, and the accuracy of liquid separation is very difficult to guarantee

Method used

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  • Microfluid control chip and system
  • Microfluid control chip and system
  • Microfluid control chip and system

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0031] Such as Figure 1 to Figure 6 As shown, a microfluidic control chip includes an upper substrate 1, an elastic membrane 18 and a lower substrate 22, the upper substrate 1, the elastic membrane 18 and the lower substrate 22 are sequentially sealed and connected from top to bottom, and the upper substrate 1 The inside of the inner body is provided with a left side fluid chamber 2, a middle control chamber 3 and a right side fluid chamber 4 sequentially in the transverse direction, wherein the number of the middle control chamber 3 is at least one; , the air port A10, the air port B11 and the air port C12 connected between the middle control chamber 3 and the right fluid chamber 4; the number of the air port B11 corresponds to the number of the middle control chamber 3;

[0032] The elastic film 18 elastically acts on the upper surface of the lower substrate 25;

[0033] The upper surface of the lower substrate 25 is provided with a liquid inlet A5 and a liquid outlet A6 a...

Embodiment 2

[0040] Such as Figure 7 to Figure 12As shown, different from Embodiment 1, the number of middle control chambers 3 in this embodiment is 2, and the volumes after the maximum elastic deformation of the elastic membrane 18 in the two middle control chambers 3 are different. As a preference, the left The deformation volume of the middle control chamber 3 on the side may be 500 nanoliters, and the deformation volume of the middle control chamber 3 on the right side may be 100 nanoliters. The middle control chamber 3 on the left side dispenses 500 nanoliters at a time, and the middle control chamber 3 on the right side dispenses 100 nanoliters at a time. If you need to dispense 600 nanoliters, you only need to work once on the left and right sides, which improves the precision of liquid dispensing , and increased the separation speed.

[0041] Such as Figure 13 As shown, the present invention also provides a microfluidic control system, including an air circuit controller 21, a...

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Abstract

Disclosed are a microfluid control chip and system. In the chip, an upper substrate, an elastic film and a lower substrate are connected to each other in order in a sealing manner, the inside of the upper substrate is provided with a left fluid cavity, a middle control cavity and a right fluid cavity in order, the surface of the upper substrate is provided with a gas port A, a gas port B and a gasport C, a microfluid channel A, a microfluid channel B and a microfluid channel C are arranged in the lower substrate, the surface of the lower substrate is provided with a main liquid inlet, a mainliquid outlet, a liquid inlet A, a liquid outlet A, a liquid inlet B, a liquid outlet B and a liquid inlet-outlet C, the two ends of the microfluid channel A respectively communicate with the main liquid inlet and the liquid inlet A, the two ends of the microfluid channel B respectively communicate with the liquid outlet A and a liquid inlet B, the middle part of the microfluid channel B communicates with the liquid inlet-outlet C, and the two ends of the microfluid channel C respectively communicate with the liquid outlet B and the main liquid outlet. In the system, a gas path controller is connected to the corresponding gas ports through gas paths, and the main liquid inlet of the chip is connected to a to-be-distributed liquid source through a liquid inlet pipeline. The control chip andsystem can effectively improve the accuracy of liquid separation.

Description

technical field [0001] The invention belongs to the technical field of liquid distribution, and in particular relates to a microfluidic control chip and a system. Background technique [0002] In biological and chemical applications, the movement and distribution of liquid reagents is one of the most basic operations. The automatic liquid dispenser is currently the most widely used liquid distribution device. The traditional automatic liquid dispenser is mostly based on the air in the compressed bottle to pump out the liquid, and the solenoid valve is used to control the flow at the outlet to achieve the liquid suction and liquid distribution. Purpose. For this working method, when pipetting a small amount of liquid, for example, when the volume of the liquid to be pipetted is less than 1 microliter, the error will increase sharply, and the accuracy of liquid separation is very difficult to guarantee. Contents of the invention [0003] In view of the problems existing in...

Claims

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Application Information

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IPC IPC(8): B01L3/00
CPCB01L3/502784
Inventor 倪小莉
Owner 徐州昊洋生物科技有限公司