Externally applied liranaftate solution for treating fungal infection of pet and preparation method thereof

A technology for liranaftate and fungal infection, which is applied in directions such as medical preparations, antifungal agents, and drug delivery of non-active ingredients, can solve problems such as obstacles, user inconvenience, strong skin irritation, etc., and achieves simple process, Easy-to-accept, easy-to-prepare effects

Active Publication Date: 2019-07-30
LUOYANG HUIZHONG ANIMAL MEDICINE
View PDF5 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Zefnart Solution 2% mainly exerts its antifungal effect through drug penetration into the sebum, but this product has certain skin irritation, especially when the affected area is damaged due to scratching, the skin irritation is more intense, which brings inconvenience to the user. It also has greater obstacles when it is promoted as pet medicine

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Externally applied liranaftate solution for treating fungal infection of pet and preparation method thereof
  • Externally applied liranaftate solution for treating fungal infection of pet and preparation method thereof
  • Externally applied liranaftate solution for treating fungal infection of pet and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 2

[0030] Preparation Example 2: Preparation of liranaphtate solution of the present invention

[0031] The components are as follows:

[0032]

[0033] Preparation method: In step A, at room temperature of 25°C, put the weighed liranaftyl ester, BHT, and BHA into the weighed ethyl acetate, diethyl sebacate, and appropriate amount of glycerin fatty acid ester, palm Stir in a stirring tank of isopropyl phosphate, the stirring speed range is 1000rpm / min, and the stirring time range is 30min, until it is completely dissolved, then add the remaining glycerin fatty acid ester to constant volume, and filter with a 0.45um nylon filter membrane to obtain a semi-finished product.

[0034] In step B, the above-mentioned semi-finished product is taken, filled and packaged.

Embodiment 3

[0035] The skin irritation research of embodiment 3 non-broken skin:

[0036] 3.1 Experimental supplies

[0037] Test drug:

[0038] Prepared by Luoyang Huizhong Veterinary Medicine Co., Ltd.; liranaphtate topical solution prepared in Example 1 of the present invention; liranaphtate topical solution prepared in Example 2 of the present invention; Japanese product ZEFNARTSOLUTION 2%.

[0039] Test animals:

[0040] 10 New Zealand white rabbits, weighing 2.5-3kg, half male and half male.

[0041] 3.2 Operation steps

[0042] Preparation of Rabbit Skin

[0043] Shave the hair on both sides of the rabbit’s back and spine 24 hours before administration. The shaved area on each side is about 3cm×3cm. Before administration, check whether the depilated skin is damaged due to depilation. Eight fur rabbits were used for the experiment.

[0044] Method of administration

[0045] Select 8 rabbits with intact skin after shaving, apply 0.5mL / only on the skin that has been shaved on t...

Embodiment 4

[0067] Embodiment 4 damaged skin irritation research:

[0068] 4.1 Experimental supplies

[0069] Test drug:

[0070] Luoyang Huizhong Veterinary Medicine Co., Ltd.; liranaphtate topical solution prepared in Example 1 of the present invention; liranaphtate topical solution prepared in Example 2 of the present invention; Japanese product ZEFNARTSOLUTION 2%.

[0071] Test animals:

[0072] 10 New Zealand white rabbits, weighing 2.5-3kg, half male and half male.

[0073] 4.2 Test steps

[0074] Preparation of Rabbit Skin

[0075] 24 hours before the administration, the hair on both sides of the rabbit's back spine was shaved, and the shaved area on each side was about 3cm×3cm. Eight hairless rabbits were tested.

[0076] Method of administration

[0077] Select 8 rabbits with damaged skin after shaving, apply 0.5mL / only on the skin that has been shaved on the left side, and then cover with two layers of gauze (2.5cm×2.5cm) and a non-irritating plastic film , then fixed wi...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

The invention relates to liranaftate-containing solution for treating fungal infection of a pet. The liranaftate solution contains glycerin fatty acid ester as a solvent, ethyl acetate as a cosolvent,glycerol monolaurate as a bacteriostatic agent and liranaftate. The liranaftate solution can be directly applied to damaged skin, when the liranaftate solution is applied to the pet, the acceptability is improved, and the drug efficacy is equivalent to that of a commercial product.

Description

technical field [0001] The invention relates to the invention of pet skin disease medicines, in particular to a solution for treating fungal infection of pets. Background technique [0002] Pet fungal infection is one of the common pet skin diseases in my country, accounting for 41.75% of pet skin diseases. It not only seriously affects the health of pets, but also creates favorable conditions for other pathogens to invade the skin. In particular, pets have a high probability of being infected with Microsporum canis. After infection, skin lesions and itching symptoms will occur, causing animals to scratch continuously, which will cause damage to animal skin hair follicles, rough animal fur, and affect the appearance of animals. Cause secondary infection with other fungi and bacteria. [0003] Liranaftate is a new type of third-generation thiocarbamic acid antifungal drug, which is a new product of the third class of chemical drugs. It is a squalene cyclooxygenase inhibitor...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/08A61K31/44A61P31/10
CPCA61K9/0017A61K9/08A61K31/44A61K47/14
Inventor 张许科田朋飞
Owner LUOYANG HUIZHONG ANIMAL MEDICINE
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap