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A method for determining drug distribution

A technology for drugs and drug solutions, applied in the field of measuring drug distribution, can solve problems such as failure to achieve expected pharmacokinetic effects and elimination, and achieve the effect of simple operation and rapid research.

Active Publication Date: 2021-10-26
BEIJING NORMAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Therefore, the drug development process should be a rational transition, which requires an early evaluation and later clinical trials. The early assumptions may be quite satisfactory, but in the later clinical trials, it is often because the expected pharmacokinetics cannot be achieved in the body. was eliminated due to learning effect

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  • A method for determining drug distribution
  • A method for determining drug distribution
  • A method for determining drug distribution

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Embodiment Construction

[0043] The present invention will be described in further detail below in conjunction with the accompanying drawings and examples. The following examples are only descriptive, not restrictive, and cannot limit the protection scope of the present invention.

[0044] All percentages, parts, ratios, etc. herein are by weight unless otherwise indicated.

[0045] The materials, methods, and examples herein are exemplary and should not be construed as limiting unless otherwise specified

[0046] This example is used to illustrate a basic implementation method of the present invention, that is, the theoretical value obtained by the method for determining the drug is compared with the experimental results to determine that the method has a better ability to measure the distribution and absorption of the drug.

[0047] The inventive idea of ​​the present invention is: most tissues and organs of the human body are mainly composed of fat, protein and water, and the difference in the abso...

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Abstract

The invention discloses a method for measuring drug distribution, which comprises the following steps: 1) measuring blood / water, fat / water, protein / water partition coefficients of drugs; 2) establishing in vitro model formulas of drug absorption and distribution in various tissues , the in vitro model formula is: PC t =v l P l +v p P p +v w P w , the distribution coefficient of drug concentration / blood drug concentration in various tissues (organs) of the human body can be obtained through the in vitro model formula. The method for measuring drug distribution provided by the present invention is simple and convenient to operate, and it can also simultaneously predict the absorption and distribution of a drug in multiple organs of the human body (heart, brain, liver, kidney, lung, muscle, fat) This situation provides a new direction for easier and faster research on drug distribution.

Description

technical field [0001] The invention belongs to the fields of new drug design and pharmacokinetic research and development, and in particular relates to a method for measuring drug distribution. Background technique [0002] The research and development of new drugs requires a lot of money. It is also a very time-consuming process from design, to synthesis, to drug efficacy testing and in vivo experiments. , distribution (distribution, D), metabolism (metabolism, M), excretion (excretion, E) (hereinafter referred to as ADME) properties have not been fully studied and investigated factors and were eventually eliminated. Thorough characterization and in-depth study of drug ADME properties can effectively support the drug development and research process, making drug production safer and developing new drugs more efficient. [0003] In the process of drug experimentation and research, it is often found that a certain molecule has a significant effect in treating a certain dise...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N33/50
CPCG01N33/5008
Inventor 张华北杨晓李仕林农姻铃
Owner BEIJING NORMAL UNIVERSITY