Application of mitochondrial fission factor (MFF) to heart failure

A mitochondrial, diastolic technology, applied in the field of medicine, can solve problems such as the complexity of gene regulatory networks and the lack of therapeutic methods

Active Publication Date: 2019-08-09
PKU HKUST SHENZHEN HONGKONG INSTITUTION
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

Although many molecular pathways can lead to changes in organisms at the organ or tissue level, due t

Method used

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  • Application of mitochondrial fission factor (MFF) to heart failure
  • Application of mitochondrial fission factor (MFF) to heart failure
  • Application of mitochondrial fission factor (MFF) to heart failure

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Experimental program
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Embodiment Construction

[0019] The specific embodiments of the present invention will be described below in conjunction with the accompanying drawings.

[0020] 1. Materials

[0021] 1. Source and treatment of experimental animals or materials

[0022] The animals were salt-sensitive Dahl-SS (Salt Sensitive) rats from Beijing Vital River Laboratory Animal Technology Co., Ltd.

[0023] Experimental group: fed 8% high-salt feed; control group: fed 0.3% low-salt feed.

[0024] The salt-sensitive rats in the experimental group and the control group were fed for 7 weeks, and the 7-week-old rats were bought for 14 weeks. Salt-sensitive rats fed a high-salt diet developed heart failure with preserved ejection fraction at 7 weeks.

[0025] 2. Drugs and reagents:

[0026] The primary antibody was Abcam brand; the secondary antibody was Abcam brand; TUNEL reagent was purchased from Roche Company (used for staining); Hoechst reagent was purchased from Solebol Company (used for staining).

[0027] 3 instrum...

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Abstract

The invention discloses application of a mitochondrial fission factor (MFF) to a heart failure, and particularly relates to application of the MFF to preparation of drugs for treating and detecting heart failure diseases. Provided data show that in a plurality of diastolic heart failure rats, the change (rise) of the MFF expression quantity is positively correlated with the diastolic heart failure, MFF protein causes apoptosis by promoting mitochondrial fission, the MFF can further be applied to clinical detection of the diastolic heart failure, meanwhile, the MFF can further be applied to development of the heart failure drugs, and a new method and scheme are provided for treatment of the diastolic heart failure.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to MFF used as a marker of diastolic heart failure and its application in clinical detection of diastolic heart failure. Background technique [0002] Due to the complex interaction of environmental and genetic risk factors, the mortality rate of HFpEF (heart failure with preserved ejection fraction) is increasing year by year. According to the change of ejection fraction, heart failure can be divided into: heart failure with reduced ejection fraction and heart failure with preserved ejection fraction. Mortality in heart failure patients with preserved ejection fraction has been on the rise in recent years. Heart failure with preserved ejection fraction is clinically manifested as left ventricular diastolic dysfunction, elevated left ventricular diastolic pressure, and impaired regional systolic function. Its pathophysiological changes are related to many determinants, including ...

Claims

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Application Information

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IPC IPC(8): G01N33/68
CPCG01N33/6848G01N2333/4706G01N2800/325
Inventor 霍云龙谭文长张闻熙王璇
Owner PKU HKUST SHENZHEN HONGKONG INSTITUTION
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