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A fluorescent probe for detecting mercury ions and its preparation method and application

A fluorescent probe and mercury ion technology, applied in the field of cation detection, can solve the problems of low accuracy and achieve low cost, good application prospects, and good selectivity

Active Publication Date: 2021-11-30
JIANGHAN UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

"Turn-on" and "turn-off" type fluorescent probes both realize the detection of the target through the change of the single fluorescence emission spectrum, so they are easily affected by the light source and the sample environment during the detection process, resulting in accurate detection lower

Method used

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  • A fluorescent probe for detecting mercury ions and its preparation method and application
  • A fluorescent probe for detecting mercury ions and its preparation method and application
  • A fluorescent probe for detecting mercury ions and its preparation method and application

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Embodiment Construction

[0027] In order to better understand the above technical solution, the technical solution of the present application will be described in detail below through specific examples. It should be understood that the embodiment of the present application and the specific features in the embodiment are a detailed description of the technical solution of the present application, rather than a detailed description of the technical solution of the present application. For the limitation of the technical solution, the embodiments of the present application and the technical features in the embodiments may be combined without conflict. It should be understood that as used herein, the term "and / or" includes any and all combinations of one or more of the associated listed items.

[0028] Neither the endpoints nor any values ​​of the ranges disclosed herein are limited to such precise ranges or values, and these ranges or values ​​are understood to include values ​​approaching these ranges or...

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Abstract

The invention provides a fluorescent probe for detecting mercury ions and its preparation method and application. Its chemical name is 3-(4-(1,3,5,7-tetramethyl-8 propyl) boron difluoride Pyrrole-4-carbonyl)piperazine)-rhodamine B hydrazide, the fluorescent probe of the present invention uses the boron fluoride dipyrrole fluorescent dye BODIPY unit as an energy donor, and the rhodamine unit is an energy acceptor. Mercury ions promote the "open-close" of the spiroamide ring to realize the fluorescence energy resonance transfer of BODIPY and rhodamine units, resulting in a red shift of fluorescence, which can be used to detect Hg 2+ The fluorescent ratio probe; the fluorescent probe is based on m-hydroxyphenylpiperazine and 2-(4-diethylamino)-2-hydroxyl)-benzoic acid as raw materials, and then reacted with 1,3,5 , 7‑Tetramethyl‑8‑propoxycarbonyl succinimide) obtained by condensation reaction of boron fluoride dipyrrole. The probe of the invention is a FRET-based ratiometric fluorescent probe with high sensitivity and good selectivity, which can detect mercury ions in water phase.

Description

technical field [0001] The invention relates to the technical field of cation detection; in particular, it relates to a fluorescent probe for detecting mercury ions, a preparation method and application thereof. Background technique [0002] Mercury ion (Hg 2+ ) is a very physiologically toxic heavy metal ion, which can be directly enriched in the human body through the skin, digestive tract or respiratory tract, and cause various extremely lethal diseases, such as Minamata disease, which is very harmful. Hg 2+ The mechanism of causing the disease has not been fully studied, and it is widely accepted that Hg 2+ It can combine with certain sulfur-containing groups (such as sulfhydryl) in proteins in the body to form Hg-S complexes, leading to protein inactivation. Important physiological activities in the body are accomplished by proteins, such as nucleoproteins that form the nucleus and affect cell functions; enzyme proteins can promote food digestion, absorption and util...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07F5/02C09K11/06G01N21/64
CPCC07F5/022C09K11/06C09K2211/1029C09K2211/1044C09K2211/1055C09K2211/1088G01N21/643G01N2021/6432
Inventor 文丹喻艳华邓宣凯舒婷婷杨智慧
Owner JIANGHAN UNIVERSITY
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