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Bacteriostatic care solution for oral cavity complications occurring during head and neck neoplasm radiotherapy

A technology for head and neck tumors and complications, applied in the field of medicine, can solve the problems of affecting the quality of life of patients with radiotherapy effects and poor symptomatic treatment effects, and achieve the effects of enhancing the coolness of mint, preventing the occurrence of radioactive caries, and promoting remineralization Effect

Inactive Publication Date: 2019-08-23
贵州四季常青药业有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Head and neck tumors (nasopharyngeal carcinoma, oral cavity cancer, and laryngeal cancer, etc.) are one of the common clinical malignant tumors, and radiotherapy plays an important role in the treatment of head and neck tumors; since head and neck tumors are mostly adjacent to normal oral tissues, radiotherapy is inevitable Cause different degrees of radiation damage to oral salivary glands and mucosal epithelial cells, resulting in decreased saliva secretion, decreased PH value, and bacterial flora imbalance, resulting in radiation-induced xerostomia, mucositis, ulcers, dental caries, gingivitis, periodontal disease, alveolar abscess, Common clinical complications such as taste loss seriously affect the effect of radiotherapy and the quality of life of patients; at present, there is still a lack of specific drugs for radiotherapy oral complications, and the symptomatic treatment effect is not good; therefore, it is urgent to research and develop new products with more specificity

Method used

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  • Bacteriostatic care solution for oral cavity complications occurring during head and neck neoplasm radiotherapy

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] A bacteriostatic nursing solution for head and neck tumor radiotherapy oral complications, comprising the following raw materials in parts by weight: artificial saliva 3.0345g, hydroxymethylcellulose 8g, bacteriostatic enhancer 1g, traditional Chinese medicine additive 240g, flavoring agent 26g .

[0029] Further, the artificial saliva includes the following raw materials in parts by weight: NaCl 0.35g, KCl 0.35g, CaCl 2 2H 2 O 0.780g, NaHPO 4 2H 2 O 0.75g, Na 2 S·2H 2 O 0.0045g, Urea 0.8g.

[0030] Further, the antibacterial enhancer is chlorhexidine acetate.

[0031] Further, the raw materials of the traditional Chinese medicine additive are in parts by weight: 140 g of Ophiopogon japonicus, 50 g of honeysuckle, 40 g of dark plum, and 10 g of licorice.

[0032] Further, the raw materials of the flavoring agent are 15 g of glycerin, 8 g of acesulfame K, 2 g of natural menthol, and 1 g of flavoring in parts by weight.

Embodiment 2

[0034] A bacteriostatic nursing solution for head and neck tumor radiotherapy oral complications, comprising the following raw materials in parts by weight: artificial saliva 3.815g, hydroxymethylcellulose 12g, bacteriostatic enhancer 3g, traditional Chinese medicine additive 320g, flavoring agent 45g .

[0035] Further, the artificial saliva includes the following raw materials in parts by weight: NaCl 0.0.45g, KCl 0.45g, CaCl 2 2H 2 O 0.810g, NaHPO 4 2H 2 O 0.85g, Na 2 S·2H 2 O 0.0055g, Urea 1.2g.

[0036] Further, the antibacterial enhancer is chlorhexidine acetate.

[0037] Further, the raw materials of the traditional Chinese medicine additive are in parts by weight: 160 g of Ophiopogon japonicus, 70 g of honeysuckle, 60 g of dark plum, and 30 g of licorice.

[0038] Further, the raw materials of the flavoring agent are 25 g of glycerin, 12 g of acesulfame K, 5 g of natural menthol, and 3 g of flavoring in parts by weight.

Embodiment 3

[0040] A bacteriostatic nursing solution for head and neck tumor radiotherapy oral complications, comprising the following raw materials in parts by weight: artificial saliva 3.38g, hydroxymethylcellulose 10g, bacteriostatic enhancer 2g, traditional Chinese medicine additive 280g, flavoring agent 35g .

[0041] Further, the artificial saliva includes the following raw materials in parts by weight: NaCl 0.4g, KCl 0.4g, CaCl 2 2H 2 O0.795g, NaHPO 4 2H 2 O part 0.78g, Na 2 S·2H 2 O 0.005g, Urea 1g.

[0042]Further, the antibacterial enhancer is chlorhexidine acetate.

[0043] Further, the raw materials of the traditional Chinese medicine additive are in parts by weight: 150 g of Ophiopogon japonicus, 60 g of honeysuckle, 50 g of dark plum, and 20 g of licorice.

[0044] Further, the raw materials of the flavoring agent are 20 g of glycerin, 10 g of acesulfame K, 3 g of natural menthol, and 2 g of flavoring in parts by weight.

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Abstract

The invention relates to the technical field of medicine, in particular to a bacteriostatic care solution for oral cavity complications occurring during head and neck neoplasm radiotherapy. By adoption of artificial saliva, hydroxymethyl cellulose, a traditional Chinese medicine additive, a bacteriostatic intensifier and a flavoring agent as raw materials and through a reasonable proportion design, the bacteriostatic effect of the care solution is effectively improved, and the care solution has good treatment and prevention effects on common clinical complications such as radioactive oral cavity xerosis, mucositis, ulcers, dental caries, gingivitis, periodontal diseases, alveolar abscess and gustation lowering caused by head and neck neoplasm radiotherapy. The bacteriostatic care solutionhas the advantages that the care solution is fresh in mouthfeel, ice-cold, tasty, safe and free of irritation, has the scent of mint and does not contain alcohol, and therefore, the oral cavity bacteriostatic care solution has a definite bacteriostatic care effect and a brand-new formula.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to an antibacterial nursing solution for oral complications of radiotherapy for head and neck tumors. Background technique [0002] Head and neck tumors (nasopharyngeal carcinoma, oral cavity cancer, and laryngeal cancer, etc.) are one of the common clinical malignant tumors, and radiotherapy plays an important role in the treatment of head and neck tumors; since head and neck tumors are mostly adjacent to normal oral tissues, radiotherapy is inevitable Cause different degrees of radiation damage to oral salivary glands and mucosal epithelial cells, resulting in decreased saliva secretion, decreased PH value, and bacterial flora imbalance, resulting in radiation-induced xerostomia, mucositis, ulcers, dental caries, gingivitis, periodontal disease, alveolar abscess, Common clinical complications such as taste loss seriously affect the effect of radiotherapy and the quality of life o...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61K9/08A61K47/10A61K47/22A61P1/02A61P31/02A61K31/155A61K31/717A61K33/04A61K33/14A61K33/16A61K33/42
CPCA61K9/08A61K31/155A61K31/717A61K33/04A61K33/14A61K33/16A61K33/42A61K36/355A61K36/484A61K36/736A61K36/8968A61K47/10A61K47/22A61P1/02A61P31/02A61K2300/00
Inventor 张圣贵隋东虎
Owner 贵州四季常青药业有限公司
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