Hydrophobic polysaccharide and its preparation method and application
A technology of hydrophobization and polysaccharides, applied in the field of hydrophobization polysaccharides and its preparation, can solve the problems of indole acetic acid failure, soil and water pollution, poor formulation of pesticides, etc., and achieve the effect of solving poor biocompatibility
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Embodiment 1
[0073]Example 1 Hydrophobized polysaccharide and its preparation method
[0074]The hydrophobized polysaccharide prepared in this example is the reaction of the hydroxyl group of dextran with glycylglycine, firstly prepare glycylglycine glucan ester, and then react with oleic acid, so that the carboxyl group of glycylglycine is esterified with oleic acid , Get hydrophobized dextran. The specific preparation method is as follows:
[0075]1. Dissolve 100g (0.01mol) dextran in 2L of N,N dimethylformamide (DMF), add 1.6g (0.01mol) amino-protected glycylglycine, add 1g catalyst DMAP and dehydrating agent DCC 10g, reacted at room temperature for 48h, filtered to remove the by-product dicyclohexylurea, the filtrate was added with a small amount of water to terminate the reaction, and 2L of absolute ethanol was added to obtain a white precipitate called glycylglycine glucan ester.
[0076]2. Add 100 g of glycylglycine glucan ester to 1L of 1N NAOH aqueous solution to remove the protective group to f...
Embodiment 2
[0079]Example 2 Hydrophobized polysaccharide and its preparation method
[0080]The specific preparation method is as follows:
[0081]1. Dissolve 100g (0.01mol) dextran in 4L of N,N dimethylformamide (DMF), add 3.2g (0.02mol) amino-protected glycylglycine, add 2g catalyst DMAP and dehydrant 20g of DCC, reacted at 40°C for 24h, filtered to remove the by-product dicyclohexylurea, the filtrate was added with a small amount of water to terminate the reaction, and 4L of anhydrous methanol was added to obtain a white precipitate called glycylglycine glucan ester.
[0082]2. Add 100 g of glycylglycine glucan ester to 2L of 1N NAOH aqueous solution to remove the protective group to free the amino group of glycylglycine, and distill the reaction system under reduced pressure to remove water.
[0083]3. Reconstitute the deprotected glycylglycine glucan ester 100g in 4L DMF, add 5.6g (0.02mol) oleic acid, add 2g catalyst DMAP and 20g dehydrating agent DCC, react at 40℃ for 24h, filter The by-product dicy...
Embodiment 3
[0084]Example 3 Hydrophobized polysaccharide and its preparation method
[0085]The specific preparation method is as follows:
[0086]1. Dissolve 100g (0.01mol) dextran in 1L of N,N dimethylformamide (DMF), add 2.4g (0.015mol) amino-protected glycylglycine, add 0.5g catalyst DMAP and dehydration Reagent DCC 5g, react at 50°C for 12h, filter to remove the by-product dicyclohexylurea, add a small amount of water to the filtrate to terminate the reaction, add 1L of absolute ethanol to obtain a white precipitate that is glycylglycine glucan ester.
[0087]2. Add 100g of glycylglycine glucan ester to 500ml of 1N NAOH aqueous solution to remove the protective group to free the amino group of glycylglycine, and distill the reaction system under reduced pressure to remove water.
[0088]3. Dissolve 100g of the above-mentioned deprotected glycylglycine glucan ester in 1LDMF, add 4.2g (0.015mol) oleic acid, add 0.5g catalyst DMAP and 5g dehydrating agent DCC, react at 50℃ for 12h, filter The by-product ...
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