Preparation method of soluble microneedle patch for rabies vaccine
A rabies vaccine and micro-needle sticker technology, applied in the directions of micro-needles, needles, and medical devices, can solve the problems of easy breakage of the needle body, increased manufacturing costs, residues, etc., and achieves flexible assembly methods, excellent mechanical properties, and flexible shapes. control effect
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[0038] Example 1 Preparation of Rabies Vaccine Soluble Microneedle Patch
[0039] (1) Preparation of PDMS horizontal mold by UV-LIGA method
[0040] First, mix PDMS and curing agent uniformly at a mass ratio of 10:1, place them in a vacuum drying oven, and vacuum for 5 minutes at a vacuum degree of 0.08Mpa to remove bubbles in the solution, and then stand for use;
[0041] Second, prepare a silicon substrate, sputter a layer of nickel on the silicon substrate, and pre-process it to ensure absolute cleanliness;
[0042] Then, a layer of 100μm thick SU-8 glue is thrown on the pre-processed silicon substrate, and the mask is used for photolithographic development. The shape of the mask is the same as the shape of the needle body of the microneedle;
[0043] Finally, pour the previously evacuated PDMS solution, place it in an oven, dry it at 60°C for 5 hours and then take it out, and then demold the PDMS horizontal mold.
[0044] The shape of the needle in the present invention can be such a...
Example Embodiment
[0056] Example 2 Comparison of needle types of microneedles prepared by different preparation methods
[0057] The soluble microneedles were prepared according to the method of Example 1 of the present invention and the traditional reverse mold method, and the prepared soluble microneedles were all placed under a scanning electron microscope to measure and calculate the average height of the microneedles after demolding, and obtain the high uniformity Under the premise (no significant difference, P greater than 0.05) the percentage of microneedles, the height of the two molds are both 500μm, the number of needles are both 50, and there are 20 parallel. The calculation results are shown in Table 1.
[0058] Table 1 Investigation of the high uniformity of microneedles with different preparation methods
[0059] Preparation Traditional moulding Method of the invention Average height of microneedle (μm)446.5*486.7* Highly uniform acquisition rate (%)65100
[0060] *Refers to the h...
Example Embodiment
[0062] Example 3 Comparison of microneedles prepared by different preparation methods in skin penetration and peeling experiments
[0063] Prepare rabies vaccine soluble microneedle patches with the same number of needles and the same backing area according to the down-mold method, 3D printing method, and the method of Example 1 of the present invention. The soluble microneedle patches prepared by the three methods are pierced with an applicator. Into the isolated pig skin to ensure that all three microneedles have penetrated the skin. One minute after the administration, the backing layer of the microneedles was peeled off, and the conditions of the microneedles and the backing layer after peeling were observed.
[0064] The observation results are shown in Table 2. It can be seen from Table 2 that all the needles are left in the skin only by the method of the present invention, indicating that the rabies vaccine can be completely vaccinated.
[0065] Table 2 Summary table of solu...
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