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Chromatographic system for separating organic acids and organic acid esters, and method thereof

An organic acid ester and chromatographic system technology, applied in separation methods, chemical instruments and methods, solid adsorbent liquid separation, etc., can solve the problems of large space occupation, slow processing speed, low efficiency, etc., and achieve long service life of the medium Effect

Pending Publication Date: 2019-09-06
上海渔霁生物技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In addition, conventional resin media can separate organic acids, but resin media use a large amount of inorganic strong acids and alkalis, and occupy a large space, slow processing speed, and low efficiency

Method used

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  • Chromatographic system for separating organic acids and organic acid esters, and method thereof
  • Chromatographic system for separating organic acids and organic acid esters, and method thereof
  • Chromatographic system for separating organic acids and organic acid esters, and method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] Such as figure 1 , 2 As shown, a chromatographic system for separating maleic acid and ethylene glycol maleate, including a liquid inlet system 1, a pump 2, a pressure sensor 3, a mixer 4, a filter column 5, a chromatographic column 6, and a pH meter connected in sequence 7. UV detector 8. Liquid outlet system 9.

[0033] Among them, the inner diameter of chromatographic column 6 is 450mm, the height is 2200mm, the inner wall roughness is ≤0.7μm, the material is 316 stainless steel, and the internal filling model is Yizhan-20ESQ-1.1-300 high-efficiency strong anion medium.

[0034] The carrier of high-efficiency strong anion media is modified SiO 2 , the aperture is The particle size is 20 μm, and the dosage is 150 kg.

[0035] The liquid inlet system 1 includes a sampling valve 111 and a sampling liquid level switch 112 , an eluting valve 121 and an eluting liquid level switch 122 , a balance purge valve 131 and a balance purge liquid level switch 132 .

[0036] ...

Embodiment 2

[0050] A chromatographic system for separating acetic acid and ethyl acetate, comprising a liquid inlet system 1, a pump 2, a pressure sensor 3, a mixer 4, a filter column 5, a chromatographic column 6, a pH meter 7, a UV detector 8, an outlet Liquid system9.

[0051] The inner diameter of the chromatographic column 6 is 400mm, the height is 2000mm, the inner wall roughness is less than or equal to 0.7μm, the material is 304 stainless steel, and the internal filling model is the high-efficiency strong anion medium of Yizhan-20ESQ-1.1-300.

[0052] The carrier of high-efficiency strong anion medium is SiO 2 , the aperture is The particle size is 5 μm, and the dosage is 150 kg.

[0053] The liquid inlet system 1 includes a sampling valve 111 and a sampling liquid level switch 112 , an eluting valve 121 and an eluting liquid level switch 122 , a balance purge valve 131 and a balance purge liquid level switch 132 .

[0054] The liquid outlet system 9 includes an ethyl acetate ...

Embodiment 3

[0069] A chromatographic system for separating benzoic acid and ethyl benzoate, comprising a liquid inlet system 1, a pump 2, a pressure sensor 3, a mixer 4, a filter column 5, a chromatographic column 6, a pH meter 7, and a UV detector 8 connected in sequence , Liquid outlet system 9.

[0070] The inner diameter of the chromatographic column 6 is 500mm, the height is 3000mm, the inner wall roughness is less than or equal to 0.7μm, the material is 304 stainless steel, and the internal filling model is the high-efficiency strong anion medium of Yizhan-20ESQ-1.1-300.

[0071] The carrier of high-efficiency strong anion medium is SiO 2 , the aperture is The particle size is 15 μm, and the dosage is 150 kg.

[0072] The liquid inlet system 1 includes a sampling valve 111 and a sampling liquid level switch 112 , an eluting valve 121 and an eluting liquid level switch 122 , a balance purge valve 131 and a balance purge liquid level switch 132 .

[0073] The liquid outlet system ...

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Abstract

The invention relates to a chromatographic system for separating organic acids and organic acid esters, and a method thereof. The chromatographic system comprises a liquid feeding system (1), a pump (2), a pressure sensor (3), a mixer (4), a filter column (5), a chromatographic column (6), a pH meter (7), an UV detector (8) and liquid discharge system (9) which are sequentially connected. Separation is completed by the steps of filling with a medium protection solution, collection of the organic acid esters, collection of the organic acids, and device cleaning. Compared with the prior art, themethod of the invention overcomes the shortcomings of low speed, low efficiency and high cost and the pain spots of environmental pollution and resource wastes in the extraction, distillation and resin purification processes of existing traditional technologies, and has the advantages of high efficiency, environmental protection, energy saving, and long service life of the medium.

Description

technical field [0001] The invention relates to the field of high performance liquid chromatography separation, in particular to a chromatography system and method for separating organic acids and organic acid esters. Background technique [0002] Organic acids and organic acid esters are widely used in the fields of fine chemicals, chemical medicines, raw materials, pharmaceutical intermediates, etc., and demand and output are large. Generally, the production scale of production-oriented enterprises is at least above the ton level, so the efficiency, cost and quality of production are very important to production-oriented enterprises. [0003] At present, traditional chemical production enterprises need organic acids as raw materials to produce organic esters. Most of the products are esters, but some organic acids will remain in the system, which will affect the purity and quality of the products. Then, the organic acid and organic acid ester are separated by layering by ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): B01D15/10B01D15/42
CPCB01D15/10B01D15/424
Inventor 张超陈平朱文瑾张军东汤祥忠谢磊
Owner 上海渔霁生物技术有限公司
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