A scar repair material and preparation method thereof

A technology for repairing materials and scars. It is applied in the direction of medical formulas, medical preparations with non-active ingredients, and medical preparations containing active ingredients. It can solve problems such as poor effect, short action time, and single function, and achieve soft texture. , promote healing, high safety effect

Active Publication Date: 2021-04-13
BLOOMAGE BIOTECHNOLOGY CORP LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The object of the present invention is to provide a kind of scar repairing material, and this scar repairing material takes ectoine and allantoin as the main functional components, and the functional components are made into microcapsules with chitosan substances and hyaluronic acid substances, Microcapsules are dispersed in a three-dimensional structure with cross-linked hyaluronic acid as the main component. The whole repair material has the characteristics of good biocompatibility, anti-inflammation, promotion of repair, long-lasting and stable effect, and complete degradability. Scar repair products have shortcomings such as single function, short action time, and poor effect

Method used

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  • A scar repair material and preparation method thereof
  • A scar repair material and preparation method thereof
  • A scar repair material and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Three groups of scar repair materials A, B, and C were prepared, and the differences in the efficacy of these three groups of materials for scar prevention and repair in New Zealand rabbits were compared.

[0038] 1. Prepare microcapsules, using water-soluble chitosan and sodium hyaluronate as capsule materials, ectoine and allantoin as core materials, and the viscosity of water-soluble chitosan used is 600-800 mPa·s, The molecular weight of sodium hyaluronate used is 1500 kDa, the mass ratio of water-soluble chitosan and sodium hyaluronate is 1:1, the mass ratio of ectoine and allantoin is 100:1, the capsule material and core material The mass ratio is 10:1. The specific steps are: add chitosan to 0.6wt% acetic acid solution, mix well, add anhydrous calcium chloride, stir and dissolve in a water bath at 45°C until it is completely emulsion-like, and it is system 1; add sodium hyaluronate Stir in purified water until completely dissolved, then add a mixed solution cont...

Embodiment 2

[0047] Scar repair materials were prepared, and the commercially available silicone scar repair materials were selected as the positive control group, and the differences in their effects on new scar repair were compared.

[0048] Preparation of test group materials:

[0049] 1. Prepare microcapsules, using chitosan hydrochloride and sodium hyaluronate as capsule materials, ectoine and allantoin as core materials, and the viscosity of chitosan hydrochloride used is 200-400 mPa. s, the molecular weight of sodium hyaluronate used is 1000 kDa, the mass ratio of chitosan hydrochloride to sodium hyaluronate is 3:1, the mass ratio of ectoine and allantoin is 1:100, the capsule material The mass ratio to the core material is 3:1. The specific steps are: add chitosan hydrochloride into 1wt% acetic acid solution, mix evenly, add anhydrous calcium chloride, stir and dissolve in a water bath at 50°C until it is completely emulsion-like, which is system 1; add hyaluronic acid Add sodium...

Embodiment 3

[0061] Prepare scar repair materials and examine their mechanical strength.

[0062] 1. Prepare microcapsules, using chitosan hydrochloride and sodium hyaluronate as capsule materials, ectoine and allantoin as core materials, and the viscosity of chitosan hydrochloride used is 400~600 mPa· s, the molecular weight of sodium hyaluronate used is 2000 kDa, the mass ratio of chitosan hydrochloride to sodium hyaluronate is 3:1, the mass ratio of ectoine and allantoin is 1:100, the capsule material The mass ratio to the core material is 3:1. The specific steps are: add chitosan hydrochloride into 1wt% acetic acid solution, mix evenly, add anhydrous calcium chloride, stir and dissolve in a water bath at 50°C until it is completely emulsion-like, which is system 1; add hyaluronic acid Sodium was added into purified water and stirred until it was completely dissolved, then a mixed solution of allantoin, ectoine and DMSO was added and mixed evenly. The mass of DMSO was 40% of the mass o...

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Abstract

The invention discloses a scar repair material and a preparation method thereof. It is made of microcapsules and cross-linked hyaluronic acid gel. The microcapsules use chitosan and hyaluronic acid Ketoin and allantoin are core materials, and the microcapsules are evenly dispersed in the cross-linked hyaluronic acid gel, and the chitosan substance is chitosan or / and chitosan derivatives, and the hyaluronic acid Substances are hyaluronic acid or / and hyaluronate. The scar repair material of the present invention is highly safe, and the microcapsules embedded with ectoine and allantoin can work continuously and stably in the cross-linked hyaluronic acid gel scaffold, have good biocompatibility, excellent Scar repair, healing promotion, anti-inflammation function, at the same time, the mechanical strength of the material is controllable, can be completely degraded, and has a wider range of applications.

Description

technical field [0001] The invention relates to a scar repair material, in particular to a scar repair material containing ectoine microcapsules and a preparation method thereof, belonging to the technical field of scar repair. Background technique [0002] Human skin is mainly composed of epidermis, dermis and subcutaneous tissue. The dermis is mainly composed of collagen secreted by fibrous precursor cells. The collagen fibers that make up collagen are arranged neatly to maintain the smoothness, luster, elasticity and toughness of the skin. However, under trauma or infection such as burning, scalding, acne, surgery, etc., the dermis composed of collagen is damaged and the collagen structure is disordered, and the organisms in the human body cannot completely repair the complex structures of the dermis and subcutaneous tissue. When the epidermis is torn and the dermis is injured, the wound can only be repaired by connective tissue. The surface layer of the skin can be repa...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/62A61K47/36A61K31/505A61K31/4166A61P17/02
CPCA61K9/5036A61K31/4166A61K31/505A61P17/02A61K2300/00
Inventor 冯晓毅宋永民宫衍革刘栋姜秀敏甄文博郭学平
Owner BLOOMAGE BIOTECHNOLOGY CORP LTD
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