Microbubble synergistic dynamics experiment system and method based on dual-frequency superimposed ultrasonic pulses in viscoelastic media

An ultrasonic pulse and experimental system technology, applied in the field of ultrasound, can solve problems such as insufficient cavitation activity, inaccurate setting of thermal ablation and tissue damage parameters, and non-linear effect of excitation waveform, so as to improve efficiency and safety Effect

Active Publication Date: 2020-06-19
XI AN JIAOTONG UNIV
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Problems solved by technology

[0005] The existing methods of thermal ablation and tissue damage still have the following defects: Biological tissue is a kind of compressible fluid with viscoelasticity, and there are theoretical deficiencies in the development of HIFU process guided by the microbubble model in RPNNP incompressible fluid. There is no viscoelastic model in compressible fluid for simulation to guide the HIFU process, and the previous excitation waveform did not consider the nonlinear effect, resulting in inaccurate setting of thermal ablation and tissue damage parameters, and the cavitation activity in the focal area in single-frequency mode is not intense enough , so that the cavitation threshold is too high, the required peak sound pressure is too high, and the volume of the single focus is only a few mm 3

Method used

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  • Microbubble synergistic dynamics experiment system and method based on dual-frequency superimposed ultrasonic pulses in viscoelastic media
  • Microbubble synergistic dynamics experiment system and method based on dual-frequency superimposed ultrasonic pulses in viscoelastic media
  • Microbubble synergistic dynamics experiment system and method based on dual-frequency superimposed ultrasonic pulses in viscoelastic media

Examples

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Embodiment 1

[0098] 1) Prepare a bovine serum albumin (BSA) polyacrylamide gel imitation with a mass fraction of 7%, and add bovine serum albumin as a temperature change indicator. The density of the gel phantom is 1.06g / cm 3 , the speed of sound in the finished gel phantom is 1477±5m / s, and the sound attenuation coefficient is 0.42±0.01dB / cm.

[0099] 2) the annular HIFU transducer 5, and the B-ultrasound probe etc. such as figure 1 Place and fix as shown, inject an appropriate amount of degassed water into the reaction vessel, and open the thermostat 7 . Turn on the ultrasound imaging device, and adjust the point to be damaged in the gel phantom to the focal point of the transducer according to the image guidance.

[0100] 3) According to Figure 11 Write the signal waveform to be generated by the arbitrary waveform generator.

[0101] 4) The computer 10 controls the timing of the signal excitation module and the monitoring and guiding module, so that the damage and monitoring of the...

Embodiment 2

[0105] 1) Prepare acrylamide mimic body fluid. Select fresh pig kidneys, cut them into a size of 5mm×3mm×30mm, fix them in simulated body fluid, and solidify them at room temperature.

[0106] 2) the annular array HIFU transducer 5, and the B-ultrasound probe etc. such as figure 1 To fix, inject an appropriate amount of degassed water into the reaction vessel, and open the thermostat 7. Turn on the ultrasound imaging equipment, and adjust the center position of the pig kidney to the focal point of the transducer according to the image guidance.

[0107] 3) According to Figure 11 Program the signal to be generated by the arbitrary waveform generator. The sound power was set to 240W throughout the process.

[0108] 4) Connect channel 1 of the arbitrary waveform generator in the synchronous signal control system to the ultrasonic excitation system, and channel 2 to the guidance monitoring system. Turn on each device and manually trigger the synchronization signal control sy...

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Abstract

The present invention discloses a dual -frequency superposition micro -foam -efficient dynamic experimental system and method in a dual -frequency superposition. The experimental method includes: 1) The actual waveform of the coke area measured according to the water hearing device, set the KZK equation parameterNon -linear incentive waveforms; 2) Construct HIFU efficiency models according to the vibration characteristics of the viscosity and micro -bubbles in the biological tissue and micro bubbles in compressed fluids;The simulation results of the steps determine the HIFU waveform phase, sound pressure, and frequency parameters for thermal ablation or tissue damage experiments.The present invention makes full use of the dynamic characteristics of micro -bubbles in biological tissues, designing sound wave -shaped and phase parameters, causing the maximum vibration of micro -bubbles in the coke area, enhancing the effect of emptiness, and improving the safety and efficiency of HIFU thermal melt and tissue damage.Essence

Description

technical field [0001] The invention belongs to the field of ultrasonic technology, and in particular relates to a microbubble synergistic dynamics experiment system and method in a viscoelastic medium. Background technique [0002] High Intensity Focused Ultrasound (HIFU) has become a hot spot in the field of therapeutic ultrasound due to its non-invasive and strong focusing characteristics. At present, there are two mechanisms of action of high-intensity focused ultrasound: thermal ablation mechanism and tissue damage mechanism. The traditional HIFU thermal ablation mode mainly uses the thermal effect of ultrasound. The high-intensity ultrasound energy focused from the outside to the target area ablates the tissue locally, causing coagulation necrosis of the target tissue due to the instantaneous high temperature; the tissue damage (Histotripsy) mode mainly uses The cavitation mechanical effect of HIFU shatters the target tissue into micron-sized fragments. [0003] The ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01H9/00G06F30/20G09B23/28
CPCG01H9/002G01H9/004G09B23/28G06F30/20
Inventor 陆明珠刘邺晖李瑞昕刘妍杉李玉娇王轩耿一喆万明习
Owner XI AN JIAOTONG UNIV
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