Sustained release aspirin liposome hydrogel and preparation method as well as application of sustained release aspirin liposome hydrogel in preparing medicine for treating recurrent lumbar disc herniation

A technology for sustained-release aspirin lipid and lumbar disc herniation, applied in the preparation of drugs for the treatment of recurrent lumbar disc herniation, in the field of sustained-release aspirin liposome hydrogel, which can solve the problem of inability to prevent and treat nucleus pulposus re-herniation inflammation Problems such as intervertebral disc degeneration and failure to achieve fibrous annulus closure can achieve the effect of delaying intervertebral disc degeneration, better controlling release ability, and slowing down intervertebral disc degeneration

Active Publication Date: 2019-09-27
THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, aspirin therapy alone cannot achieve closure of the annulus fibrosus defect after discectomy, and cannot prevent and treat inflammation and disc degeneration caused by reherniation of the nucleus pulposus

Method used

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  • Sustained release aspirin liposome hydrogel and preparation method as well as application of sustained release aspirin liposome hydrogel in preparing medicine for treating recurrent lumbar disc herniation
  • Sustained release aspirin liposome hydrogel and preparation method as well as application of sustained release aspirin liposome hydrogel in preparing medicine for treating recurrent lumbar disc herniation
  • Sustained release aspirin liposome hydrogel and preparation method as well as application of sustained release aspirin liposome hydrogel in preparing medicine for treating recurrent lumbar disc herniation

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Experimental program
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Effect test

Embodiment 1

[0047] 1. Preparation and study of aspirin-loaded liposomes (ASP-Lip)

[0048] 1.1 Preparation of aspirin-loaded liposomes (ASP-Lip)

[0049] Aspirin-loaded liposomes (ASP-Lip) were prepared by thin-film dispersion method. The lipid materials lecithin and cholesterol (4 / 1, w / w) were mixed together with aspirin dissolved in chloroform (50 / 1, w / w). Then the solution of these composite materials was transferred to an eggplant flask, and the organic solution was removed by a rotary vacuum evaporator at a speed of 100 r / min, and the temperature of the water bath was 30 °C. In the flask body, after gentle evaporation, a uniform honeycomb film is formed. In addition, by rotating (100 r / min) and heating (30 °C), using preheated 40 °C deionized water (dd H 2 O) Hydration of these films. The initial drug-loaded liposomes were prepared, and then ultrasonically extruded on polycarbonate membranes with different diameters (0.45 μm, 0.22 μm) to prepare aspirin-loaded liposomes (ASP-Lip)...

Embodiment 2

[0089] 1. Grouping of experimental animals

[0090] The experiment was divided into four groups: normal control group, defect group, aspirin hydrogel group, and sustained-release aspirin liposome hydrogel group (Table 1). Experimental studies were performed on different lumbar segments.

[0091] Table 1 Grouping of experimental animals

[0092]

[0093] 2. Establishment of rabbit intervertebral disc degeneration model

[0094] New Zealand white rabbits have 7 lumbar vertebrae. Routinely fasting for 12 h and drinking for 4 h before the operation. Sumianxin 0.2 mL / kg was injected into the thigh muscle, and 2 mg / mL pentobarbital sodium 5 mL was injected into the thigh muscle. After about 20 minutes, the rabbit could completely enter the anesthesia state. Intramuscular injection of anesthetic can greatly reduce the risk of intravenous anesthesia. Preoperative intramuscular injection of 800,000 units of penicillin. After routine shaving and skin preparation, Aner Iodine was...

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Abstract

The invention discloses sustained release aspirin liposome hydrogel and a preparation method as well as application of the sustained release aspirin liposome hydrogel in preparing a medicine for treating recurrent lumbar disc herniation after discectomy. The sustained release aspirin liposome hydrogel comprises aspirin, lipidosome and gelatin methylacryloyl hydrogel; the effect and a possible mechanism of treating intervertebral disc degeneration caused by fiber ring defect by the sustained release aspirin liposome hydrogel are proved through observation of structural characteristics and mechanical characteristics of the sustained release aspirin liposome hydrogel and tests of the influence of an in vitro material on the inflammation of nucleus pulposus cells and in vivo rabbit fiber ring defect modeling; ASP-Lip+GelMA is proved to show excellent performance in the aspect of filling rabbit partial fiber ring defect part, maintaining the mechanical stability and controlling local inflammation and provides a new treatment prospect for preventing the recurrent lumbar disc herniation after partial discectomy.

Description

technical field [0001] The invention relates to the field of medicines, in particular to a sustained-release aspirin liposome hydrogel, its preparation method and its application in the preparation of medicines for treating recurrent lumbar disc herniation. Background technique [0002] Lumbar disc herniation is a common low back pain disease in orthopedics, especially in spine surgery. With the aggravation of intervertebral disc degeneration, surgery is the final choice for most patients. Surgery can significantly reduce nerve compression and pain caused by herniated nucleus pulposus. However, studies of traditional discectomy for low back pain have shown 20%-40% recurrent sciatica or disc herniation in different studies. The study by Kim et al. showed that the recurrence rate of intervertebral disc herniation in young adults was 7.1%. In addition, a large data study shows that the incidence of intervertebral disc herniation is 10%-27%, and the incidence of reoperation i...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K9/127A61K47/42A61K31/616A61P19/08A61P29/00
CPCA61K9/06A61K9/127A61K9/0019A61K47/42A61K31/616A61P19/08A61P29/00
Inventor 耿德春毛海青崔文国刘禹彭鹏柏家祥林佳益葛高然徐耀增杨惠林
Owner THE FIRST AFFILIATED HOSPITAL OF SOOCHOW UNIV
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