Method for detecting drug sensitivity rapidly

A drug-sensitivity and rapid technology, applied in the direction of microorganism-based methods, biochemical equipment and methods, measuring devices, etc., can solve the problems of long detection time, limited types of antibacterial drugs, unfavorable long-term detection of drug resistance, etc., and achieve simple operation Effect
CN110305933AInactive Publication Date: 2019-10-08AUTOBIO DIAGNOSTICS CO LTD
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
AUTOBIO DIAGNOSTICS CO LTD
Publication Date
2019-10-08
Estimated Expiration
Not applicable · inactive patent

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Abstract

The invention discloses a method for detecting drug sensitivity rapidly. The method includes the steps of 1, mixing nutrient broth with antibacterials to prepare an antibacterial diluent with gradientchange in concentration; 2, preparing a standard bacterial suspension of strain to be detected with super pure water, and diluting the broth for standby use; 3, respectively adding the standard bacteria suspension diluted by the broth of the same volume in the antibacterial diluent prepared in the step 1, dropwise adding the obtained mixture to a sample plate of a mass spectrometer for sample application according to the concentration gradient of the antibacterial diluent, and incubating for 2.0-5.0 hours after sample application is completed; 4, after incubation, discarding the broth, drying, dropwise adding a mass spectrometry identification pretreatment reagent, performing microbiological identification with the mass spectrometer after crystallization and reading the result.The pretreatment operation of the method is simple, accurate drug sensitivity result can be provided more quickly and intuitively, and a certain reference can be provided for clinical guidance and rational use of drugs in a timely manner.
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Description

Technical field

[0001] The invention relates to the field of drug susceptibility detection, in particular to a method for rapidly detecting drug susceptibility. Background technique

[0002] Antibiotics (ie antibacterial drugs) have a wide range of clinical applications and have made great contributions to the prevention and treatment of human diseases. In recent years, with the increase in the types of antibiotics, clinical dependence on antibacterial drugs has become more and more serious. Due to the unreasonable use or abuse of antibiotics, bacteria have developed drug resistance, and the phenomenon of increasing drug resistance has seriously threatened human health. . The detection rate of various multi-drug-resistant bacteria and pan-drug-resistant bacteria continues to increase, and even super drug-resistant bacteria appear. The development speed of new drugs is far behind the production speed of drug-resistant bacteria, which has brought clinical anti-infection treatment....

Claims

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