Degradable antibacterial magnesium alloy and preparation method thereof

An antibacterial magnesium and alloy technology, applied in medical science, tissue regeneration, prosthesis, etc., can solve the problems of bacterial infection and preparation difficulties of implant materials, and achieve the effects of reducing the latent heat of solidification, firm bonding, and improving antibacterial properties

Active Publication Date: 2019-10-25
NORTHEASTERN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0012] The technical task of the present invention is to provide a degradable antibacterial magnesium alloy and its preparation method in view of the problems that the current implant materials are easy to cause bacterial infection and difficult to prepare

Method used

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  • Degradable antibacterial magnesium alloy and preparation method thereof
  • Degradable antibacterial magnesium alloy and preparation method thereof
  • Degradable antibacterial magnesium alloy and preparation method thereof

Examples

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Effect test

Embodiment 1

[0039] An antibacterial and degradable magnesium alloy, the mass fractions of each component of the material are: Ag: 1.35%, Cu: 0.9%, Zn: 3.6%, Sr: 0.9%, Ca: 0.36%, unavoidable Fe, Among impurities such as Al, the content of a single impurity is less than 0.02%, the total amount of impurities does not exceed 0.1%, and the balance is Mg.

[0040] Based on the magnesium alloy of above-mentioned composition, its preparation method step is as follows:

[0041] Another aspect of the present invention provides a preparation method based on the above-mentioned materials, the method comprising the following steps:

[0042] (1) Ingredients: Calculate and prepare the raw materials required for magnesium alloy bone screws. The mass fraction of silver in high-purity silver wire is ≥99.99%, the mass fraction of silver in high-purity copper wire is ≥99.99%, the mass fraction of zinc in high-purity zinc particles is ≥99.99%, and the mass fraction of zinc in high-purity zinc particles is ≥9...

Embodiment 2

[0047] An antibacterial and degradable magnesium alloy, the mass fractions of each component of the material are: Ag: 1.5%, Cu: 1.0%, Zn: 4%, Sr: 1.0%, Ca: 0.4%, unavoidable Fe, Among impurities such as Al, the content of each single impurity is less than 0.02%, the total amount of impurities is not more than 0.1%, and the balance is Mg.

[0048] Based on the magnesium alloy of above-mentioned composition, its preparation method step is as follows:

[0049] Another aspect of the present invention provides a preparation method based on the above-mentioned materials, the method comprising the following steps:

[0050] (1) Ingredients: Calculate and prepare the raw materials required for magnesium alloy bone screws. The mass fraction of silver in high-purity silver wire is ≥99.99%, the mass fraction of silver in high-purity copper wire is ≥99.99%, the mass fraction of zinc in high-purity zinc particles is ≥99.99%, and the mass fraction of zinc in Mg-Sr master alloy is ≥99.99%. ...

Embodiment 3

[0055] An antibacterial and degradable magnesium alloy, the mass fractions of each component of the material are: Ag: 1.65%, Cu: 1.1%, Zn: 4.4%, Sr: 1.1%, Ca: 0.44%, unavoidable Fe, Among impurities such as Al, the content of each single impurity is less than 0.02%, the total amount of impurities is not more than 0.1%, and the balance is Mg.

[0056] Based on the magnesium alloy of above-mentioned composition, its preparation method step is as follows:

[0057] Another aspect of the present invention provides a preparation method based on the above-mentioned materials, the method comprising the following steps:

[0058] (1) Ingredients: Calculate and prepare the raw materials required for magnesium alloy bone screws. The mass fraction of silver in high-purity silver wire is ≥99.99%, the mass fraction of silver in high-purity copper wire is ≥99.99%, the mass fraction of zinc in high-purity zinc particles is ≥99.99%, and the mass fraction of zinc in high-purity zinc particles i...

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Abstract

The invention provides a degradable antibacterial magnesium alloy and a preparation method of the degradable antibacterial magnesium alloy, and relates to the field of metal biomedical materials. Thedegradable antibacterial magnesium alloy comprises main active elements of Ag, Cu, Zn and Sr, and by means of composition optimization design of the magnesium alloy, the components comprise, by mass,1.35-1.65% of Ag, 0.9-1.1% of Cu, 3.6-4.4% of Zn, 0.9-1.1% of Sr, 0.36-0.44% of Ca and the balance Mg and other inevitable impurities. After the magnesium alloy material implant finishes the action, the magnesium alloy material implant can be completely degraded to avoid secondary operation removal, the medical cost and the pain of patients are reduced, the antibacterial property of the implant isimproved, and the magnesium alloy material implant has the functions of promoting osteoblast formation and inhibiting osteoclast bone absorption; the degradable antibacterial magnesium alloy adopts asemi-solid rheological die casting process, the microstructure of the product is uniformly distributed, the internal structure is compact, the defects of pores, segregation and the like are few, andthe requirements for high quality and high precision of implant products can be met.

Description

technical field [0001] The invention relates to the field of metal medical implant materials, in particular to a degradable antibacterial magnesium alloy and a preparation method thereof. Background technique [0002] Magnesium alloys have become a new generation of medical biomaterials due to their excellent properties such as low density, high specific strength, good processability and biocompatibility, and are favored by biomaterial researchers and medical personnel. Compared with traditional medical metal materials and degradable polymer materials, magnesium alloy has the following outstanding advantages as a medical implant material: [0003] (1) Good biocompatibility [0004] Magnesium is an essential mineral for human metabolism and an indispensable element for the nervous system. Many cases are related to its deficiency. Magnesium is second only to calcium and phosphorus in the mineral content of the human body, and its content is second only to potassium in the io...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C22C23/04C22C1/03B22D17/00A61L27/04A61L27/54A61L27/58
CPCA61L27/047A61L27/54A61L27/58A61L2300/102A61L2300/404A61L2300/412A61L2430/02B22D17/007C22C1/03C22C23/04
Inventor 铁镝颜路飞任浩博张博彧管仁国刘立忠
Owner NORTHEASTERN UNIV
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