Method for ovarian cancer screening based on ovarian cancer marker and logic gate operation

A technology for ovarian cancer and tumor markers, applied in the field of biomedicine, can solve the problems of large antibody molecules in detection methods, and achieve the effects of improving detection sensitivity, high sensitivity, and strong specificity
CN110426519AActive Publication Date: 2019-11-08JIANGNAN UNIV
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Patent Information

Authority / Receiving Office
CN · China
Patent Type
Applications(China)
Current Assignee / Owner
JIANGNAN UNIV
Publication Date
2019-11-08

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Abstract

The invention discloses a method for ovarian cancer screening based on an ovarian cancer marker and a logic gate operation, and belongs to the technical field of biomedicine. The protein-nucleic acidrecognition technology, the signal amplification technology and a logic gate are combined, aptamers of CEA and CA125 are used for target recognition, signal transformation and amplification are performed through a G-quadruplex-heme complex, and a method for simultaneous detection of tumor markers is established. According to the method, an optical biosensor with high sensitivity and strong specificity is constructed for achieving the joint detection of the CEA and the CA125, and an ovarian cancer screening result is provided based on the logic gate; through the combination of optical detectionand the signal amplification technology, the detection sensitivity is improved; the universality of the detection principle makes the method also suitable for detection of different objects based ondifferent protein recognition elements.
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Description

technical field

[0001] The invention relates to a method for screening ovarian cancer based on ovarian cancer markers and logic gate operations, belonging to the technical field of biomedicine. Background technique

[0002] Ovarian cancer is a malignant tumor that occurs in the ovarian tissue. It ranks third among female reproductive system malignant tumors and is the tumor with the highest gynecological mortality rate. Therefore, early detection, early diagnosis and early treatment are extremely important for the rehabilitation of ovarian cancer patients. . When the early tumor is limited to the ovary, ultrasonography is difficult to diagnose, and the increase of serum tumor markers can precede the imaging changes and clinical symptoms for several months, which has certain clinical significance for early diagnosis. Ovarian cancer has a variety of tumor markers, of which only carbohydrate antigen 125 (CA125) is clinically recognized and widely used in ovarian tumors, and th...

Claims

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