Applications of ginkgo terpene lactone in preparation of drugs and health products for preventing and/or treating vertigo
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A ginkgolide, a pharmaceutical technology, applied in the field of medicine, can solve problems such as ginkgolides that have not been seen yet
Active Publication Date: 2019-11-12
CHENGDU BAIYU PHARMA CO LTD
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Xu Jiangping reported that ginkgolides can reduce cerebrovascular resistance and increase cerebral blood flow in anesthetized dogs, but do not affect heart rate and blood pressure (Xu Jiangp...
Method used
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Embodiment 1
[0134] Example 1 Ginkgo terpene lactone mixed dropping pills
[0135] Active ingredient:
[0136] Bilobalide 1000g (1 part) Ginkgolide B 500g (0.5 part)
[0137] Ginkgolide A 250g (0.25 parts) Ginkgolide C 250g (0.25 parts)
[0138] Preparation Process
[0139] Add 1 part of glycerol monostearate, 1 part of polyethylene glycol, 1 part of carrageenan, 1 part of gum arabic, 1 part of hydroxypropyl methylcellulose, etc. to the above raw materials and mix well, then add the dripping pill with water-soluble device In the machine, heat evenly and stir at the right time. After melting, drop it into the immiscible condensate. After condensation, take out the dropping pills, wipe off the condensate adhering to the surface, and dry at low temperature.
Embodiment 2
[0140] Example 2 Ginkgo terpene lactone mixed dropping pills
[0141] Active ingredients Bilobalide 1000g (1 part) Ginkgolide B 1000g (1 part)
[0142] Preparation Process
[0143]Add 1 part of glycerol monostearate, 1 part of polyethylene glycol, 1 part of carrageenan, 1 part of gum arabic, 1 part of hydroxypropyl methylcellulose, etc. to the above raw materials and mix well, then add the dripping pill with water-soluble device In the machine, heat evenly and stir at the right time. After melting, drop it into the immiscible condensate. After condensation, take out the dropping pills, wipe off the condensate adhering to the surface, and dry at low temperature.
Embodiment 3
[0144] Example 3 Ginkgolide B Dropping Pills
[0145] Ginkgolide B 1000g (1 serving)
[0146] Preparation Process
[0147] Add 1 part of glycerol monostearate, 1 part of polyethylene glycol, 1 part of carrageenan, 1 part of gum arabic, 1 part of hydroxypropyl methylcellulose, etc. to the above raw materials and mix well, then add the dripping pill with water-soluble device In the machine, heat evenly and stir at the right time. After melting, drop it into the immiscible condensate. After condensation, take out the dropping pills, wipe off the condensate adhering to the surface, and dry at low temperature.
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Abstract
The invention relates to the field of medicines, and specifically relates to applications taking one or more ginkgo terpene lactone compounds or pharmaceutically acceptable salt, ester, hydrate and solvate thereof, or any crystal forms, racemate and metabolite thereof, or a mixture thereof as effective components in the preparation of drugs and health products for preventing and/or treating vertigo. During a process that the provided ginkgo terpene lactone is used for preventing and/or treating posterior circulation ischemic rats and meniere's disease rats, vertigo symptoms can be significantly improved; a synergistic effect occurs when the provided ginkgo terpene lactone composition is taken as the drugs for preventing and/or treating the vertigo; effects of the provided ginkgo terpene lactone for preparing the drugs for preventing and/or treating the vertigo are better than that of a ginkgo leaf extract product; and the ginkgo terpene lactone can significantly improve the conditionsof vascular vertigo and migraine vertigo patients in clinical observation tests, has no adverse reaction during medication, and is high in patient tolerance and good in medication compliance.
Description
technical field [0001] The invention relates to the field of medicine, in particular to the use of ginkgolides in the preparation of medicines and health products for preventing and / or treating vertigo. Background technique [0002] Modern studies have shown that the main active ingredients in Ginkgo biloba are flavonoids and ginkgolides. Ginkgo flavonoids include flavonol glycosides, biflavonoids, and catechins. Ginkgolide compounds include ginkgolide and bilobalide. Ginkgolides include Ginkgolide A, Ginkgolide B, Ginkgolide C, Ginkgolide J, Ginkgolide M, Ginkgolide K, Ginkgolide L, Ginkgolide N, and Ginkgolide P , Ginkgolide Q. The results of the study showed that ginkgo diterpene lactone is a diterpene lactone with a cage-like skeleton, which contains six oxygen-rich five-membered rings (including a spiro[4.4]-nonane, a tetrahydrofuran ring and three lactone rings), 10-12 stereocenters and the characteristic tert-butyl group. The difference in the structure of the is...
Claims
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Application Information
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