Unlock instant, AI-driven research and patent intelligence for your innovation.

Erbb2/her2 mutations in the transmbrane or juxtamembrane domain

A transmembrane and near-membrane technology, applied in the determination/testing of microorganisms, peptide/protein components, medical preparations of non-active ingredients, etc.

Pending Publication Date: 2019-12-03
F HOFFMANN LA ROCHE & CO AG
View PDF171 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although the precise role of ErbB4 in carcinogenesis is not well established (Koutras et al., Critical Reviews in Oncology / Hematology 74, 73-78 (2010)), transforming somatic cells in ErbB4 have been reported in melanoma Mutation (Prickett et al., Nature Genetics 41, 1127-1132 (2009))

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Erbb2/her2 mutations in the transmbrane or juxtamembrane domain
  • Erbb2/her2 mutations in the transmbrane or juxtamembrane domain
  • Erbb2/her2 mutations in the transmbrane or juxtamembrane domain

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0212] Example - Oncogenic ErbB2 mutations in tumorigenesis

[0213] Given the importance of ErbB2 in human cancers, we systematically surveyed human cancers and identified the transmembrane (TM) and juxtamembrane (JM) domains of ErbB2, as well as recurrent somatic mutations, and these mutations have also been shown to be transformative. Furthermore, we evaluated targeted therapies in ErbB2 mutant-driven cell-based and animal cancer models and showed that they effectively blocked ErbB2 mutant-driven carcinogenesis.

[0214] Materials and methods

[0215] Tumor DNA, mutation identification

[0216] Tumor DNA mutations were identified based on the observed mutation frequency of ErbB2 mutations in tumors from patients and / or those in the TM / JM domain region and junction segment that were close to the observed mutations, as indicated (Table 1).

[0217] cell line

[0218] The primary IL-3-dependent mouse B cell line BaF3 was purchased from ATCC (American Type Culture Colle...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The present disclosure relates to somatic ErbB2 mutations in cancer and provides methods of identifying, diagnosing, and prognosing ErbB2-positive cancers. The present disclosure further provides methods of treating cancer, including certain subpopulations of patients. The mutations are in the transmembrane domain or juxtamembrane domain of ErbB2.

Description

[0001] related application [0002] This application claims priority to U.S. Provisional Application Serial No. 62 / 489,382, filed April 24, 2017, and U.S. Provisional Application Serial No. 62 / 560,564, filed September 19, 2017, both of which are incorporated herein by reference in their entirety. [0003] field of invention [0004] The present disclosure relates to somatic ErbB2 (Her2) mutations in cancer and includes methods for the identification, diagnosis, treatment outcome prognosis, and treatment of ErbB2 mutant cancers. [0005] Background of the invention [0006] The human epidermal growth factor receptor (Her) family of receptor lysine kinases (RTKs), also known as ErbB receptors, consists of four members: EGFR / ErbB1 / Her1, ErbB2 / Her2, ErbB3 / Her3 and ErbB4 / Her4 (Hynes et al., Nature Reviews Cancer 5, 341-354 (2005); Baselga et al., Nature Reviews Cancer 9, 463-475 (2009)). ErbB family members contain an extracellular domain (ECD), a single transmembrane domain, an ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): C12Q1/6886A61P35/00A61K31/4709A61K31/517A61K39/395C07K16/32
CPCA61K31/4709A61K31/517C07K16/32C12Q1/6886A61K2039/55C07K2317/24C07K2317/73C12Q2600/106C12Q2600/156A61P35/00A61K47/68033A61K47/6803A61K38/00A61K45/06C07K2317/76G01N33/574G01N33/68
Inventor S·塞沙基里
Owner F HOFFMANN LA ROCHE & CO AG