Pyrazine-based d-a-d type fluorescent small molecule, preparation method and application

A D-A-D, small molecule technology, applied in the field of fluorescent probes, can solve the problems of poor dye stability, easy to detach from cells, poor photostability, etc., and achieve the effects of excellent photostability, not easy to quench, and high fluorescence quantum yield.
CN110540524BInactive Publication Date: 2020-09-18XI AN JIAOTONG UNIV
5 Cites 0 Cited by

Patent Information

Authority / Receiving Office
CN · China
Patent Type
Patents(China)
Current Assignee / Owner
XI AN JIAOTONG UNIV
Publication Date
2020-09-18
Estimated Expiration
Not applicable · inactive patent

Smart Images

  • Figure 1
    Figure 1
  • Figure 2
    Figure 2
  • Figure 3
    Figure 3
Patent Text Reader

Abstract

The invention discloses a pyrazine-based D-A-D type fluorescent small molecule, which has the following chemical structural formula defined in the specification, wherein X is simultaneously selected from hydrogen or methoxyl, and R is selected from hydrogen, fluorine and methyl ester. According to the present invention, the fluorescent small molecule is used for living cell imaging, cannot enter dead cells, has strong AIE effect, is not easily quenched under physiological conditions, and has high fluorescence quantum yield.
Need to check novelty before this filing date? Find Prior Art

Description

technical field

[0001] The invention belongs to the technical field of fluorescent probes, and in particular relates to a pyrazine-based D-A-D type fluorescent small molecule, a preparation method and an application. Background technique

[0002] A fluorescent probe is a molecular measurement device based on spectrochemistry that selectively converts the chemical information of an analysis object into a fluorescent signal that is easily measured by an analytical instrument. It has the advantages of high sensitivity, good selectivity, and convenient use. In recent years, the field of fluorescent probes has developed rapidly due to its wide application in chemical sensing, optical materials, and biology. Especially in the detection of environmental changes in cells, fluorescent probe detection has the advantages of simple operation, high sensitivity, and resolution It has the advantages of high efficiency and can realize real-time monitoring without damage. However, in cellu...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More