Elastic degradable tracheal stent and its construction method

A technology of tracheal stent and construction method, applied in the direction of stent, processing and manufacturing, prosthesis, etc., to achieve the effects of good pore connectivity, good tissue infiltration, and good elasticity

Active Publication Date: 2022-04-26
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, it has not been successfully reported that the above three conditions can be satisfied at the same time.

Method used

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  • Elastic degradable tracheal stent and its construction method
  • Elastic degradable tracheal stent and its construction method
  • Elastic degradable tracheal stent and its construction method

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Embodiment Construction

[0043] The present invention will be described in detail below in combination with specific embodiments.

[0044] The invention relates to an elastic degradable tracheal stent, the stent is a three-layer elastic tracheal composite structure, which sequentially includes a PGS tube core, a C-shaped PCL ring and a PCL sheath arranged in parallel to form a PGS tube core-C Type PCL ring-PCL sheath has elastic degradable tracheal stent material.

[0045] The PGS die is a tubular structure made of polyglycerol sebacate (PGS) material; the C-shaped PCL ring is a C-shaped structure made of polycaprolactone (PCL); the PCL sheath The layer is a polycaprolactone sheath prepared by electrospinning. The C-type PCL ring is used as the middle supporting ring layer, including at least two rings, which are equal in size and arranged in parallel axially. The inner diameter of the stent is 4-9 mm, and the outer diameter is 6-11 mm; the width of the C-type PCL ring is 2-3 mm, and the adjacent di...

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Abstract

The invention relates to an elastic degradable tracheal stent and a construction method thereof. The stent is a three-layer elastic tracheal composite structure, which sequentially includes a PGS tube core, a C-shaped PCL ring and a PCL sheath arranged in parallel from the inside to the outside; The PGS tube core is a tubular structure made of polyglycerol sebacate; the C-type PCL ring is a C-shaped structure made of polycaprolactone; the PCL sheath is polycaprolactone prepared by electrospinning. Lactone sheath. The invention obtains a tracheal stent material with good elasticity, good pore connectivity, good support, and timely degradability by constructing a three-layer elastic trachea-shaped composite stent material of PGS tube core-C-type PCL ring-PCL sheath, which is superior to Compared with other tissue engineering materials in the past, this scaffold material can achieve rapid vascularization, good tissue infiltration and good flexibility, etc., which will pave the way for subsequent clinical research.

Description

technical field [0001] The invention relates to the technical field of biomedical devices, in particular to an elastic degradable tracheal stent and a construction method thereof. Background technique [0002] Tracheal tumors, tracheal trauma, or congenital tracheal deformities often lead to tracheal stenosis and even seriously threaten the lives of patients. Clinically, the incidence of tracheal malformation is high in children with congenital heart disease. According to literature reports, tracheal malformation accounts for about 12.9% of children with congenital heart disease. In my country, the incidence of congenital heart disease accounts for 0.7%-0.8%, and it is increasing by about 150,000 children every year. Among them, many children with congenital heart disease are complicated with tracheal deformities every year. Tracheal stenosis is the most common form of tracheal malformation, and compression and softening of the trachea by cardiovascular malformations is on...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/82D01D5/00B29C33/38B29C64/153B33Y10/00
CPCA61F2/82D01D5/0007D01D5/003D01D5/0084B29C64/153B29C33/3842B33Y10/00A61F2240/002
Inventor 吴炜加三三张心驰张思倩
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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