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A Time-Resolved Wide-spectrum Cars Spectral Imaging Device Based on High Repetition Frequency Femtosecond Laser

A spectral imaging and time-resolution technology, applied in the field of optical imaging, can solve the problems of low cost, achieve the effects of improving imaging speed, suppressing non-resonant background, and improving detection sensitivity

Active Publication Date: 2020-07-10
HUAZHONG UNIV OF SCI & TECH
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] Aiming at the defects of the prior art, the purpose of the present invention is to provide a time-resolved wide-spectrum CARS spectral imaging device based on a high repetition frequency femtosecond laser, aiming at solving the difficulty of traditional CARS spectral imaging technology in maintaining a simple system structure and low cost At the same time, realize single-time detection of multiple molecules, and effectively suppress the problem of non-resonance background

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  • A Time-Resolved Wide-spectrum Cars Spectral Imaging Device Based on High Repetition Frequency Femtosecond Laser

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[0031] In order to make the object, technical solution and advantages of the present invention clearer, the present invention will be further described in detail below in conjunction with the accompanying drawings and embodiments. It should be understood that the specific embodiments described here are only used to explain the present invention, not to limit the present invention. In addition, the technical features involved in the various embodiments of the present invention described below can be combined with each other as long as they do not constitute conflicts with each other.

[0032] Such as figure 1 As shown, the present invention provides a time-resolved wide-spectrum CARS spectral imaging device based on a high-repetition-frequency femtosecond laser, including a high-repetition-frequency femtosecond laser, a double-pulse laser generation module, and a spectral imaging platform;

[0033] High repetition frequency femtosecond laser, used to generate high repetition f...

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Abstract

The invention discloses a time-resolved wide-spectrum CARS spectral imaging device based on high-repetition-frequency femtosecond laser. The device comprises a high-repetition-frequency femtosecond laser device, a double-pulse laser generation module and a spectral imaging platform. The high-repetition-frequency femtosecond laser device is used for generating fundamental frequency light with the high repetition frequency and inputting the fundamental frequency light into the double-pulse laser generation module. The double-pulse laser generation module is used for generating fundamental frequency light and frequency shift light which are suitable for coaxial transmission of the time-resolved CARS imaging technology. And the spectral imaging platform is used for realizing scanning type Raman spectral imaging of a to-be-detected sample. According to the invention, the wide-spectrum femtosecond laser is used as pump light and Stokes light at the same time and coherence among multiple energy levels can be established at one time, so that hyperspectral imaging of various molecules can be realized at the same time. A coherent excitation process and a detection light excitation process which are jointly realized by the pump light and Stokes light are separated in time and narrow-spectrum light is adopted as the pump light, so that a non-resonance background is effectively suppressed,and the detection sensitivity is greatly improved.

Description

technical field [0001] The invention belongs to the technical field of optical imaging, and more specifically relates to a time-resolved wide-spectrum CARS spectral imaging device based on a high repetition frequency femtosecond laser. Background technique [0002] Optical imaging technology has a wide range of applications in materials science, biomedicine and other fields. At present, there are still many problems in the traditional optical imaging technology. For example, general optical imaging lacks chemical specificity and cannot image the spatial distribution of a specific molecule in a sample. This lack of chemical information will largely limit the application of imaging technology; although fluorescent labeling imaging has chemical specificity However, specific molecules need to be labeled, that is, complex pretreatment of the sample is required, which is not only time-consuming and laborious, but may also change the characteristics of the sample. Moreover, there ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/65G01N21/01
CPCG01N21/01G01N21/65G01N2021/0112G01N2021/653
Inventor 曹涛倪小玲颜及堃陈瑜郭子悦黄乐刘少臻胡凯淋秦煊超彭家晖
Owner HUAZHONG UNIV OF SCI & TECH
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