Application of triterpenoid saponin compound and salt of triterpenoid saponin compound

A technology for triterpenoid saponins and compounds, which is applied in the field of triterpenoid compounds and their salts in the field of preparing analgesic drugs, can solve the problems of unsatisfactory analgesic effect and the like, and achieves good analgesic activity, is easy to obtain, and has a simple source of raw materials. Effect

Pending Publication Date: 2020-01-14
YUNNAN MINZU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, there are also analgesic drugs or pharmaceutical compositions made

Method used

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  • Application of triterpenoid saponin compound and salt of triterpenoid saponin compound
  • Application of triterpenoid saponin compound and salt of triterpenoid saponin compound
  • Application of triterpenoid saponin compound and salt of triterpenoid saponin compound

Examples

Experimental program
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Effect test

preparation example Construction

[0095] The present invention also provides a method for preparing the above-mentioned compound of formula I, the method comprising preparing the compound from a plant of the genus Gladiolus (such as Gladiolus). Preferably, alfalfaic acid, alfalfaic acid-3-O-β-D-glucoside and 16-α-hydroxy-alfalfaic acid-3-O - beta-D-glucoside. Preferably, the method has the steps of:

[0096] (1) dry and pulverize Gladiolus, extract with a solvent, and combine the extracts;

[0097] (2) concentrating under reduced pressure the extract in (1) to obtain extractum;

[0098] (3) suspending the extract in (2) in water, extracting with sherwood oil, ethyl acetate and n-butanol successively, and then steaming off the solvent with a rotary evaporator to obtain sherwood oil, ethyl acetate and n-butanol respectively. butanol extract;

[0099] (4) The ethyl acetate extract in (3) was separated by silica gel column chromatography, and 9 components (Fr.1-9 ).

[0100] (5) Purify Fr.2 in (4) by Sephade...

Embodiment 1

[0112] Inhibitory Activity of Gladiolus Extract on Writhing Response to Acetic Acid in Mice

[0113] Source of material: Gladiolus, a plant belonging to the genus Gladiolus, was collected in Kunming, Yunnan Province, and was identified as Gladiolus gandavensis Van Houtte by Associate Professor Yang Qingsong, School of Ethnic Medicine, Yunnan University for Nationalities. The specimens are preserved in the Herbarium of the School of Medicine for Nationalities, Yunnan University for Nationalities.

[0114] Preparation of gladiolus extract: crush the dried gladiolus bulbs to obtain gladiolus bulb fragments; then extract the gladiolus fragments with 95% ethanol / water reflux for 3 times, each time for 2 hours to obtain an extract ; The gladiolus extract was filtered and concentrated under reduced pressure with a rotary evaporator into an extract for later use.

[0115]Experimental model of mouse acetic acid writhing reaction inhibition (see scientific literature: Hayashi G., Takem...

Embodiment 2

[0122] Further experiments with gladiolus

[0123] Example 1 was repeated using 95% methanol / water, 70% ethanol / water and 70% acetone / water as extraction solvents respectively. The experimental results show that 95% methanol extract of Gladiolus, 70% ethanol extract of Gladiolus and 70% acetone were obtained by using 95% methanol / water, 70% ethanol / water and 70% acetone / water as extraction solvents, respectively. The extract of water / water also has significant inhibitory activity to mouse acetic acid writhing reaction, so using different concentrations of ethanol / water, methanol / water or acetone / water as extraction solvent can also obtain the mouse acetic acid writhing in gladiolus Components that inhibit body reactions. The results are shown in Table 2.

[0124] Table 2. Inhibitory effects of different solvent extracts of gladiolus on acetic acid writhing response in mice.

[0125]

[0126] n=3

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Abstract

The invention provides application of a triterpenoid saponin compound to preparation of analgesics, and particularly relates to application of a triterpenoid saponin compound shown in a formula I fortreatment of neuralgia, bone pain, muscle pain, pain caused by traumatic injury, headache, stomach pain, intestinal colic, biliary colic, renal colic and cancer pain. (Please see the specification forthe formula I). In the formula I, R1=H, glu, R2=H, OH. The invention further discloses application of a salt of the compound of the formula I to the preparation of the analgesics. The triterpenoid saponin compound can be a naturally existing organic compound or a synthetic organic compound, has strong analgesic activity, and is used as an active ingredient for preparing the analgesics or a pharmaceutical composition together with pharmaceutically acceptable carriers or excipients.

Description

technical field [0001] The present invention relates to the application of a triterpenoid compound and its salt in the preparation of analgesic drugs, in particular to the use of a triterpenoid compound and its salt which can be isolated from Iridaceae Gladiolus plants (such as gladiolus) in the preparation of analgesic drugs. Use in pain medication. Background technique [0002] As one of the most common clinical symptoms, pain has been listed as the fifth vital sign after respiration, pulse, blood pressure, and body temperature. According to the duration of the disease, pain is divided into acute pain and chronic pain. At present, chronic pain has become one of the main diseases that endanger the health of our people. There are more than 300 million patients with chronic pain in my country, and the number of chronic pain patients is increasing at a rate of 10 million to 20 million every year. What's more serious is that in recent years, the population of pain patients ha...

Claims

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Application Information

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IPC IPC(8): A61K31/704A61P29/00
CPCA61K31/704A61P29/00
Inventor 黄相中杨淬田凯李艳红李育晓逯娅李育逵
Owner YUNNAN MINZU UNIV
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