Three alpha-conus polypeptides and use thereof

Abstract

The invention discloses alpha-conus polypeptides and use thereof. The invention provides seven polypeptides: a polypeptide I of which the amino acid sequence is represented by a sequence 7 in a sequence table and in which the last amino acid residue is amidated; a polypeptide II of which the amino acid sequence is represented by a sequence 8 in the sequence table and in which the last amino acid residue is amidated; a polypeptide III of which the amino acid sequence is represented by a sequence 9 in the sequence table and in which the last amino acid residue is amidated; a polypeptide IV of which the amino acid sequence is represented by a sequence 10 in the sequence table and in which the last amino acid residue is amidated; a polypeptide V of which the amino acid sequence is representedby a sequence 11 in the sequence table and in which the last amino acid residue is amidated; a polypeptide vI of which the amino acid sequence is represented by a sequence 12in the sequence table andin which the last amino acid residue is amidated; and a polypeptide VII of which the amino acid sequence is represented by a sequence 13 in the sequence table and in which the last amino acid residueis amidated. The result of activity tests, the seven polypeptides of the general formula (I) have pain relieving effect, alpha-conus polypeptides T-1, T-2, T-3 and T-4 have obvious pain-relieving activity, and the alpha-conus polypeptides T-5, T-6 and T-7 also have obvious pain-relieving effect, and the alpha-conus polypeptides have application values in pain-reliving aspect.

Description

[0001] This application is a divisional application of the patent application with the application number 201010121879.7, the application date is March 10, 2010, and the invention title is "α-type conus polypeptide and its application". technical field [0002] The invention relates to an alpha-type conus polypeptide and its application. Background technique [0003] Cono snails belong to gastropod molluscs, and there are more than 500 species in the world, all over the world's warm sea areas. There are more than 100 species of cone snails in China, mainly distributed in my country's Xisha Islands, Hainan Island and Taiwan waters. Cono snail polypeptides are secreted by the venom glands of the cone snail venom tube and the inner wall of the poison sac. The venom of each cone snail contains 50-200 active peptides. Different species of cone snails contain different active peptides. Even the same species of taro Cone venom-from accidental stings to deliberate injection. Toxicon...

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Problems solved by technology

Clinically commonly used drugs mainly include the combination of anticonvulsants (such as leticitide and oxcarbazepine), opioids (such as morphine) and various antidepressants. Receptivity, addiction and other problems, the treatment effect is not good (Dray et al, Br J Anaesth.2008, 101(1), 48-58; Gilron et al, Expert Opin Emerg Drugs.2007, 12(1), 113 -26.)

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