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Autogenous wound tissue regeneration and repairing ointment and preparation method thereof

An autologous, wound-surface technology, applied in the directions of ointment delivery, drug combination, pharmaceutical formulation, etc., can solve the problems of cytotoxicity, accelerate blood vessels, etc., achieve the effect of less irritation, relieve pain, and achieve regeneration and repair

Active Publication Date: 2020-01-14
北京幸福益生高新技术有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] At present, most medical dressings are dressings containing bioactive glass. Bioactive glass has good bioactivity and biocompatibility, can activate the expression of genes related to wound healing, promote the proliferation and differentiation of fibroblasts, and accelerate the growth of blood vessels. generation, promote the growth of granulation tissue, promote the repair and regeneration of hard and soft tissues, and promote wound healing. reaction, causing a rapid increase in the local PH value, and its PH value can reach 13, forming a strong alkaline, with a certain degree of cytotoxicity, many patients will cause instant pain due to stimulation, and bring certain pain to the patient during use

Method used

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  • Autogenous wound tissue regeneration and repairing ointment and preparation method thereof
  • Autogenous wound tissue regeneration and repairing ointment and preparation method thereof
  • Autogenous wound tissue regeneration and repairing ointment and preparation method thereof

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preparation example Construction

[0027] A preparation method of wound tissue autogenous regenerative repair ointment, comprising:

[0028] (1) Put polyethylene glycol 400 and polyethylene glycol 4000 into a container, heat to 75°C to dissolve, and stir for 10-20 minutes at the same time, until polyethylene glycol 400 and polyethylene glycol 4000 are mixed evenly to prepare A solution ;

[0029] (2) Add glycerin to solution A, stir at 75°C for 20-30 minutes, mix glycerol and solution A evenly, and prepare solution B;

[0030] (3) Add regenerative medical materials to solution B for a certain number of times, stir at 75°C for 60-90 minutes, mix regenerative medical materials with solution B evenly, and prepare solution C;

[0031] (4) Add medical-grade vitamin E oil to solution C, and continue to stir at 75°C for 40-70 minutes. Mix medical-grade vitamin E oil and solution C evenly to prepare solution D;

[0032] (5) Continue to stir the D solution evenly until the temperature drops to room temperature, and th...

Embodiment 1

[0040] A self-derived regenerative repair ointment for wound tissue, which is composed of the following raw materials in parts by weight: 10 parts of regenerative medical materials, 5 parts of polyethylene glycol 4000, 30 parts of polyethylene glycol 400, 5 parts of glycerin, and medical grade vitamin E 0.5 part of oil, each part of the regenerative medicine material comprises the following components: P 2 o 5 10-25 parts, SiO 2 20-60 parts, Na 2 O 2-20 parts, CaO 15-45 parts.

[0041] Preparation:

[0042] (1) Put 30 parts of polyethylene glycol 400 and 5 parts of polyethylene glycol 4000 into a container, heat to 75°C to dissolve, and stir for 10-20 minutes at the same time, until the polyethylene glycol 400 and polyethylene glycol 4000 are mixed evenly Prepared into A solution;

[0043] (2) Add 5 parts of glycerin to solution A, stir at 75°C for 20-30 minutes, mix glycerol and solution A evenly, and prepare solution B;

[0044] (3) Divide 10 parts of regenerative medi...

Embodiment 2

[0048] A self-derived regenerative repair ointment for wound surface, which is composed of the following raw materials in parts by weight: 40 parts of regenerative medical materials, 20 parts of polyethylene glycol 4000, 80 parts of polyethylene glycol 400, 25 parts of glycerin, medical grade vitamin E 3 parts of oil, each part of the regenerative medicine material includes the following components: P 2 o 5 10-25 parts, SiO 2 20-60 parts, Na 2 O 2-20 parts, CaO 15-45 parts.

[0049] Preparation:

[0050] (1) Put 80 parts of polyethylene glycol 400 and 20 parts of polyethylene glycol 4000 into a container, heat to 75°C to dissolve, and stir for 10-20 minutes at the same time, until the polyethylene glycol 400 and polyethylene glycol 4000 are mixed evenly Prepared into A solution;

[0051] (2) Add 25 parts of glycerin to solution A, stir at 75°C for 20-30 minutes, mix glycerol and solution A evenly, and prepare solution B;

[0052] (3) Divide 40 parts of regenerative medic...

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Abstract

An autogenous wound tissue regeneration and repairing ointment is characterized by being composed of the following raw materials (by weight): 10-40 parts of a regenerative medical material, 5-20 partsof polyethylene glycol 4000, 30-80 parts of polyethylene glycol 400, 5-25 parts of glycerin, and 0.5-3 parts of medical grade vitamin E oil. By mixing the regenerative medical material, polyethyleneglycol, glycerin and medical grade vitamin E oil according to a certain ratio in a specific way, the effect of guiding ordered creeping substitution of cells, extracellular matrix, blood vessels andother tissues can be achieved, acceleration of wound healing can be promoted, the repair of the nervous system of the wound is synchronized, the orderly growth of the new tissue fiber layer is realized, the regeneration of capillaries and hair follicles is achieved, and autogenous wound tissue regeneration and repairing are realized, and the formation of scars is inhibited. Meanwhile, the PH valueof the mixture is 7.3 to 7.8, which is closer to the pH value of the human body and is less irritating to the human body during use, thereby reducing the pain of patients.

Description

technical field [0001] The invention relates to the technical field of medicine for external use, in particular to an ointment for self-generating regeneration and repair of wound tissue and a preparation method thereof. Background technique [0002] At present, most medical dressings are dressings containing bioactive glass. Bioactive glass has good bioactivity and biocompatibility, can activate the expression of genes related to wound healing, promote the proliferation and differentiation of fibroblasts, and accelerate the growth of blood vessels. generation, promote the growth of granulation tissue, promote the repair and regeneration of hard and soft tissues, and promote wound healing. The reaction causes the local PH value to increase rapidly, and its PH value can reach 13, forming a strong alkalinity and having certain cytotoxicity. Many patients will cause instant severe pain due to the stimulation, which will bring certain pain to the patient during use. Contents o...

Claims

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Application Information

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IPC IPC(8): A61K33/42A61K9/06A61K47/10A61P17/02A61K33/00A61K33/08A61K31/355A61K31/047
CPCA61K9/0014A61K9/06A61K31/047A61K31/355A61K33/00A61K33/08A61K33/42A61K47/10A61P17/02A61K2300/00
Inventor 王菲高玉森胡方郭创洲王健张芷铭
Owner 北京幸福益生高新技术有限公司
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