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Preparation method and product of artificial ligament

A technology of artificial ligaments and artificial materials, applied in the direction of ligaments, prostheses, tissue regeneration, etc., can solve the problems that are not conducive to the growth of surrounding tissues, cells are difficult, and ligaments are too densely woven, so as to facilitate cell migration and matrix formation , Improve histocompatibility, good effect of histocompatibility

Active Publication Date: 2021-06-22
THE FIRST AFFILIATED HOSPITAL OF ARMY MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the structure of PET molecules is highly symmetrical, and the low surface energy makes it difficult for cells to attach and enter the interior of PET fibers. The osteoinductivity is poor, and there is a problem of poor bone healing between the graft and the host, and its biological activity is still unsatisfactory.
Its poor mechanical properties lead to densely woven ligaments and small fiber gaps, which are also not conducive to the growth of surrounding tissues.

Method used

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  • Preparation method and product of artificial ligament
  • Preparation method and product of artificial ligament
  • Preparation method and product of artificial ligament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Preparation of silk fibroin solution:

[0038] The 200g silk in the temperature of 100 ° C, in the Na2CO3 solution of 4-6 l mass concentration of 1 g / L, 30-40 min each time, remove the silk gel, to give the delatous silk fibroin, and will be obtained The protein is washed with deionized water, dried to constant reel at 50-60 ° C.

[0039] The calcium chloride-ethanol-water (CaCl2-EtOH-H2O) solution is formulated according to the amount of substance, and the silk fibroidin is dissolved in calcium chloride-ethanol-water (CaCl2-etoh-H2O) solution. Dissolve the silkwine protein after degumming in a constant temperature water bath, after dissolving, after dissolving, the skein protein solution was cooled to room temperature, centrifugal, 5-10 min, to obtain a filament protein solution .

Embodiment 2

[0041]At room temperature, 10 ml of 20% (mass split) silk fibroin solution was added to 50 g of polyvinyl alcohol, 30 mg chondroitin was uniformly stirred to completely dissolve, and then 20 g of type I collagen was slowly stirred to dissolve and formed a spinning solution. Wet spinning techniques for the preparation of regenerated fiber. The spinning process is: room temperature 20-25 ° C spinning solution into the spinneret by a pressure pump; from the spinning solution from the spinneret, the coagulation bath is 10% alcohol, the length of the coagulation tank is 1m; spinning Pressure 0.1 MPa; spinning rate of 5 ml / h; winding rate of 8R / min. Through the comparison of spinning process parameters, the coagulation bath affects the maximum factor, followed by spinning speed, and the pressure affects the factors. By water and different concentrations of alcoholic solidified solid bath experiments, the molding effect and performance of the regenerated fiber is best when the coagul...

Embodiment 3

[0043] At room temperature, 100 mL of 25% (mass fraction) silk fibroin solution was added to 50 g of polyvinyl alcohol, 30 mg chondroitin, and then mixed to completely dissolve, then add 15 g of type I collagen to slow stir until dissolved to form a spinning solution, adopted Wet spinning techniques for the preparation of regenerated fiber. The spinning process is: room temperature 20-25 ° C spinning solution into the spinneret by a pressure pump; from the spinning solution from the spinneret, the coagulation bath is 10% alcohol, the length of the coagulation tank is 1m; spinning Pressure 0.1 MPa; spinning rate of 5 ml / h; winding rate of 8R / min. The regenerated fiber is prepared by preparing this example NF2.

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Abstract

The invention relates to a method for preparing an artificial ligament. The artificial ligament is formed by braiding and twisting filamentary artificial materials into a rope-like object and twisting. The twist braid is made of silky artificial material with 15-25 strands as a bundle, 3 bundles are twisted into one strand, and then 3-4 strands are braided into a twist braid; the twisted rope is made of silky artificial 15‑25 pieces of material are 1 bundle, 3 bundles are twisted into one strand, and 3 strands are twisted into 1 rope. The artificial ligament obtained by the artificial ligament weaving method of the present invention has good mechanical properties, and its mechanical properties are relatively close to autologous ACL, and the stretching length of each ligament is better than autologous ACL. The braided structure of the artificial ligament of the present invention can ensure that the ligament satisfies the function of maintaining the anteroposterior and complex rotation stability of the knee joint respectively.

Description

Technical field [0001] The present invention belongs to the technical field of medical materials, involving a method of preparation of artificial ligaments and its products. Background technique [0002] As my country's national strength is growing and an increase in the increasing living standards, the incidence of ligament damage increases year by year. Taking the most common front cross-cruciate ligament, ACL damage as an example, my country's annual ligament injury is more than 10 million. The front cross-ligament is the knee inner ligament, connects the tibia and femoral, controlling the knee joint and prevents excessive forward movement or femur movement of the tibial tibia platform, and the importance of its function is to maintain and coordinate the stability of the knee joint to maintain the knee joint. The performance is stable, helping the human body to complete a variety of difficult actions, have important physiological functions. Long-term dramatic lower extremities...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61F2/08A61L27/26A61L27/50A61L27/58
CPCA61F2/08A61F2240/001A61L27/26A61L27/50A61L27/58A61L2430/10C08L89/00C08L29/04C08L5/08
Inventor 王富友张颖陈光兴杨柳
Owner THE FIRST AFFILIATED HOSPITAL OF ARMY MEDICAL UNIV
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