A liquid-fillable control valve and microfluidic chip for microfluidic control

Abstract

The invention provides a microfluidic control valve and a microfluidic control chip, including a control head, a valve body and a chip substrate, and the chip substrate, valve body and control head are sequentially arranged on the microfluidic chip from bottom to top. Above, the chip substrate includes a base, and the base is provided with a guide groove I and a mounting hole; the valve body is installed in the mounting hole, and the valve body is provided with a liquid inlet hole I that runs through the valve body in the vertical direction. There are several drainage ports at the bottom; the control head includes a pressing block and a guide tube, the guide tube is set under the pressing block, the bottom end of the guide tube is set in the guide groove Ⅰ, and an extrusion rod is arranged in the guide tube, and the extrusion rod It is arranged under the pressing block, and the control head is provided with a liquid inlet hole II, which is connected with the liquid inlet hole I, and the extrusion rod is arranged directly above the valve body. The valve area is integrated into one area, which can further reduce the volume of the microfluidics, reduce the number of execution structures of the detection equipment, and further simplify the equipment.

Description

technical field [0001] The invention relates to the field of microfluidic technology, in particular to a microfluidic control valve and a microfluidic chip. Background technique [0002] Microfluidics is a technology for precisely controlling and manipulating micro-scale fluids. It integrates the basic operating units of sample preparation, reaction, separation, and detection in biological, chemical, and medical analysis processes into a micron-scale chip, and automatically completes the entire analysis process. process. As a highly integrated microfluidic detection carrier, the microfluidic chip has a high degree of integration of the detection platform, so the optimization of the detection platform is one of the key issues in the promotion of microfluidic technology. The primary link of microfluidic detection is liquid addition and valve control. At present, the commonly used microfluidic chips are mostly separated from the liquid addition area and the valve area. The liq...

AI Technical Summary

Problems solved by technology

The primary link of microfluidic detection is liquid addition and valve control. At present, the commonly used microfluidic chips are mostly separated from the liquid addition area and the valve area. The liquid addition and valve control are completed by different actuators, and the liquid addition, The valve area is mostly controlled by the upper and lower sides of the chip, and the mechanism space is relatively large. At the same time, most microfluidic chips are coated with PDMS, and the elasticity of PDMS is used to control the opening of the flow channel. The driving force is mostly pneumatic, and the gas circuit structure is complex. and noisy

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