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Traditional Chinese medicine extract, medicinal composition, cataplasm and preparation methods thereof

A composition and extract technology, applied in the direction of drug combination, pharmaceutical formula, non-central analgesics, etc., can solve the problem of small drug loading in patches

Inactive Publication Date: 2020-02-14
SHANGHAI RONGXUAN BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The cataplasm of the present invention combines acupoint application therapy and drug transdermal absorption, overcomes the single effect of external treatment of the cataplasm, can treat both symptoms and root causes, warms the meridians, dispels cold and relieves pain, and overcomes the defect of small drug loading in the patch , heat resistance, formability and adhesion all have good performance, and the permeability is good, the quality controllability is good, and it has a good effect on alleviating or treating dysmenorrhea, so it has a high application and promotion prospect

Method used

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  • Traditional Chinese medicine extract, medicinal composition, cataplasm and preparation methods thereof
  • Traditional Chinese medicine extract, medicinal composition, cataplasm and preparation methods thereof
  • Traditional Chinese medicine extract, medicinal composition, cataplasm and preparation methods thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0073] This Example 1 is used to investigate the selection of the extraction solvent in the traditional Chinese medicine extract.

[0074] In each experiment, the raw materials of traditional Chinese medicine were 200 g, including 58 g of Dodder, 28 g of Psoralea, 58 g of Artemisia argyi, 8 g of cinnamon, 18 g of Chuanxiong, 10 g of Scutellaria baicalensis and 20 g of Paeonia lactiflora. Wherein, the psoralea is salt psoralea, and the preparation method of the salt psoralen is as follows: taking net psoralea, and frying it until slightly bulging according to the salt-boil method.

[0075] The extracted solvent is water or different volumes of ethanol aqueous solution, wherein 40% ethanol aqueous solution, 60% ethanol aqueous solution and 80% ethanol aqueous solution mean that the volume of ethanol accounts for 40%, 60% and 80% of the total volume of the ethanol aqueous solution, respectively.

[0076] The extraction method is reflux extraction.

[0077] In the investigation o...

preparation Embodiment 1

[0082] Preparation Example 1 Preparation of poultice

[0083] (1) Preparation of Chinese herbal extracts

[0084] Dodder 12g, psoraleae 6g, mugwort 12g, cinnamon 2g, Chuanxiong 4g, Scutellaria baicalensis 2g and white peony root 4g were mixed, rolled into coarse powder, heated and refluxed twice with 80% ethanol aqueous solution of 7.5 times the volume of water absorption, and the combined extraction The filtrate was concentrated under reduced pressure to a density of 1.10-1.12 (at 60°C), allowed to stand overnight, and then the precipitate was removed, which was the traditional Chinese medicine extract, and its mass was 8 grams.

[0085] Wherein, the psoralea is salt psoralea, and the preparation method of the salt psoralen is as follows: taking net psoralea, and frying it until slightly bulging according to the salt-boil method.

[0086] (2) Preparation of poultice

[0087] Mix 39.08 grams of water, 0.3 grams of tartaric acid, PVPK-90 (2 grams), 8 grams of sorbitol, 0.1 gr...

preparation Embodiment 2

[0090] Preparation Example 2 Preparation of the Paeonia lactiflora poultice

[0091] The preparation method of the Paeonia suffruticosa poultice is as described in Preparation Example 1, the difference is that Paeonia suffruticosa is absent.

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Abstract

The invention discloses a traditional Chinese medicine extract, a medicinal composition, cataplasm and preparation methods thereof. The traditional Chinese medicine extract is prepared by the following preparation method. The preparation method comprises the following steps: performing reflux extraction on a traditional Chinese medicine composition by an ethanol aqueous solution. The traditional Chinese medicine composition comprises the following components: semen cuscutae, fructus psoraleae, folium artemisiae argyi, cinnamon, ligusticum wallichii, white paeony root and scutellaria baicalensis, wherein the weight part ratio is (5-7):(2-4):(5-7):(0.5-1):(1-3):(1-3):1. The medicinal composition comprises an aqueous phase and an oil phase; and the aqueous phase comprises the traditional Chinese medicine extract. The cataplasm comprises the medicinal composition and auxiliary materials. The cataplasm provided by the invention can treat both symptoms and root causes, has the effects of warming meridians, dissipating cold and relieving pain and overcomes the defect that patch has small medicine loading capacity, so high application and popularization prospects are achieved.

Description

technical field [0001] The invention relates to a traditional Chinese medicine extract, a pharmaceutical composition, a poultice and a preparation method thereof. Background technique [0002] Dysmenorrhea is one of the common diseases in women, its etiology is complex, the treatment is difficult, and it is easy to recur. Modern medicine believes that dysmenorrhea is caused by abnormal uterine contractions, uterine ischemia, hypoxia, cyclic changes in sex hormones and stimulation of the uterine isthmus plexus. Therefore, Western medicine usually uses hormone drugs to inhibit ovulation and inhibit endometrial growth. Attenuate uterine activity to achieve therapeutic purposes. Traditional Chinese medicine believes that dysmenorrhea is due to the rapid changes of qi and blood in the cells before and after the menstrual period, and is susceptible to the interference of case factors, resulting in two types of symptoms. [0003] Since dysmenorrhea occurs in the uterus, many poul...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/71A61K36/65A61K9/70A61P29/00A61P15/00
CPCA61K9/7061A61K36/236A61K36/282A61K36/39A61K36/43A61K36/487A61K36/539A61K36/54A61K36/65A61K36/71A61K2236/333A61K2236/39A61P15/00A61P29/00A61K2300/00
Inventor 汤春琳江寒沁姚譞韩润
Owner SHANGHAI RONGXUAN BIOTECH
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