A strain of Bacillus subtilis and its application in fermentative production of adenosine

Abstract

A strain of Bacillus subtilis and its application in fermentative production of adenosine, wherein the Bacillus subtilis is Bacillus subtilis ( Bacillus subtilis ) ACA301, the Bacillus subtilis ACA301 is preserved in China General Microorganism Culture Collection Management Center, and the culture preservation number is CGMCC No.16753. The stability of the Bacillus subtilis ACA301 in the present invention is greatly improved, and a breakthrough has been made in technology. The production of adenosine by fermentation of this strain has a relatively high level of yield and conversion rate, and is significantly advanced. , and the fermentation raw materials are easy to obtain, the cultivation conditions are extensive, and the control process is simple, so it is suitable for industrial production and has good industrial application prospects.

Description

technical field

[0001] The invention relates to the field of biological technology, in particular to a strain of Bacillus subtilis and its application in fermentative production of adenosine. Background technique

[0002] Adenosine (Adenosine), chemical name 6-amino-9-β-D-ribofuranosyl-9-hydropurine, adenosine is an important nucleotide derivative, which is the product of adenine nucleotide dephosphorylation. As an endogenous nucleoside throughout human cells, it can directly enter the myocardium to be phosphorylated to generate adenosine, and participate in myocardial energy metabolism. Adenosine plays important roles in biochemistry, including energy transfer in the form of adenosine triphosphate (ATP) or adenosine diphosphate (ADP), or signal transmission in the form of cyclic adenosine monophosphate (cAMP). In addition, adenosine is an inhibitory neurotransmitter and plays an important role in neurotransmission. Adenosine is widely used in medicine and other industries...