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Application of pyrazolopyrimidine derivatives for treatment of Arthus reaction

A technology of pyrazolopyrimidine and derivatives, which is applied in the field of pyrazolopyrimidine derivatives and the treatment of Arthus reaction, can solve problems such as no Arthus reaction use, and achieves expanded drug selectivity, multiple drug selection, and expanded application range. Effect

Pending Publication Date: 2020-02-25
GUANGXI WUZHOU PHARMA GRP
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  • Description
  • Claims
  • Application Information

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Benefits of technology

This patented process offers several benefits compared to previous methods that were developed earlier or improved over time. It allows us to expand our ability to target specific molecules involved in arteritis attacks without affecting their effectiveness at other areas like blood vessels.

Problems solved by technology

This patented technical problem addressed in this patents relates to finding ways for treating inflammatory responses caused by certain substances or agents that may trigger these reactions.

Method used

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  • Application of pyrazolopyrimidine derivatives for treatment of Arthus reaction
  • Application of pyrazolopyrimidine derivatives for treatment of Arthus reaction
  • Application of pyrazolopyrimidine derivatives for treatment of Arthus reaction

Examples

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Embodiment 1

[0027] Effect of Example 1 on Rat Arthus Response

[0028] 1. Experimental animals: SD rats, clean grade, half male and half male, body weight (200±20) g, purchased from Beijing Huafukang Biotechnology Co., Ltd.

[0029] 2. Experimental materials: pyrazolopyrimidine derivatives were synthesized by the inventors. Mix castor oil and ethanol 1:1 and pass through a 0.22 μm sterile filter membrane to obtain ELE solution, weigh a certain amount of pyrazolopyrimidine derivative powder of the present invention, dissolve the powder with ELE solution, and after the powder is completely dissolved, Add a certain volume of sterilized water, mix well and set aside. The volume ratio of ELE solution to sterile water is 1:3.

[0030] 3. Model establishment: According to "Pharmacological Experimental Methodology" published in 2002, edited by Xu Shuyun, each rat was intramuscularly injected with 0.5 mL per week, a total of 6 times, the first 3 times were ovalbumin-complete Freund's adjuvant, a...

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Abstract

The invention relates to the technical field of medicines, in particular to an application of pyrazolopyrimidine derivatives in treatment of Arthus reaction. The Arthus reaction is associated with antigen and antibody binding to form an immune complex. The pyrazolopyrimidine derivative disclosed by the invention can be used for remarkably relieving skin redness and swelling symptoms and reducing the expression level of immune complexes and IL-2 in serum, and has the good treatment effect on the Arthus reaction.

Description

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Claims

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Application Information

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Owner GUANGXI WUZHOU PHARMA GRP
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