A kind of anti-biological pollution coating and preparation method thereof, implantable medical device

An anti-biological contamination and coating technology, which is applied in the field of medical devices, can solve the problems of low coating stability, anti-biological contamination, and non-degradability, and achieve the effects of low cost, strong hydrophilicity, and good biocompatibility

Active Publication Date: 2021-11-02
HANGZHOU WEIMING XINKE TECH CO LTD +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] The purpose of the present invention is to provide an anti-biological pollution coating, which can solve the problems of low stability, non-degradable, and small adhesion of existing coatings.

Method used

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  • A kind of anti-biological pollution coating and preparation method thereof, implantable medical device

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0077] An anti-biological contamination coating is suitable for metal surfaces, such as metal bodies used to encapsulate / support implanted medical devices, or implants whose main body is metal, and applicable metals include titanium, or tantalum, or gold, Or platinum, or stainless steel or its alloys, etc. Coating preparation method and steps are as follows:

[0078] The first step is to place the metal surface in a 3mg / mL dopamine solution and soak for 24 hours. After the dopamine molecules oxidize and polymerize into polydopamine on the metal surface, rinse the surface with deionized water to remove the residual dopamine molecules.

[0079] The second step is to soak it in 4mg / mL GRVGEVGRVGEVGRVGEV polypeptide solution for 48 hours, and rinse the surface of the material with deionized water after soaking to remove the polypeptide molecules not connected to the polydopamine layer.

[0080] The third step is to soak it in DMEM medium (no phenol red, glucose concentration 4.5g...

Embodiment 2

[0083] An anti-biological contamination coating is suitable for metal surfaces, such as metal bodies used to encapsulate / support implanted medical devices, or implants whose main body is metal, and applicable metals include titanium, or tantalum, or gold, Or platinum, or stainless steel or its alloys, etc. Coating preparation method and steps are as follows:

[0084] The first step is to place the metal surface in a 3mg / mL dopamine solution and soak for 24 hours. After the dopamine molecules oxidize and polymerize into polydopamine on the metal surface, rinse the surface with deionized water to remove the residual dopamine molecules.

[0085] The second step is to soak it in 6mg / mL SKISDISKISDISKISDI polypeptide solution for 24 hours. After soaking, rinse the surface of the material with deionized water to remove the polypeptide molecules that are not connected to the polydopamine layer.

[0086] The third step is to soak it in DMEM medium (no phenol red, glucose concentratio...

Embodiment 3

[0089] The difference from Example 1 is that the concentration of dopamine used in the first step is different, which is 4 mg / mL, and the rest of the steps and conditions are exactly the same.

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Abstract

The invention relates to an anti-biological pollution coating, a preparation method thereof, and an implanted medical device. An anti-biological pollution coating comprises a bottom layer and a surface layer, the bottom layer is polydopamine, and the surface layer is a self-assembled ion-complementary polypeptide. The preparation process is as follows: in-situ polymerization on the surface of a predetermined substrate to form a polydopamine layer; coating or impregnating the ion-complementary polypeptide on the surface of the polydopamine layer, and then through induced self-assembly to form a self-assembled ion Complementary polypeptide layer. The invention can solve the problems of low stability, non-degradability, low adhesion and the like of the existing coating.

Description

technical field [0001] The invention relates to the field of medical devices, in particular to an anti-biological contamination coating, a preparation method thereof, and an implantable medical device. Background technique [0002] Biofouling refers to the situation in which biologically active substances such as proteins and cells adhere to the surface of materials, thereby affecting the performance of materials. Biological contamination often occurs on the surface of implantable medical devices, leading to thrombosis, inflammation, etc., which can affect the treatment effect in the slightest and affect the life of patients in severe cases. Treating the surface of implantable medical devices to reduce their surface biocontamination is a necessary process in the manufacturing process of related medical devices. [0003] In researches at home and abroad, polyethylene glycol (PEG) and its derivatives, zwitterionic polymers and other materials can effectively reduce the biolog...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L31/10A61L31/02A61L31/14
CPCA61L31/022A61L31/10A61L31/14A61L31/148A61L2400/18A61L2420/02A61L2420/08C08L79/02C08L89/00
Inventor 许冠哲叶乐高猛
Owner HANGZHOU WEIMING XINKE TECH CO LTD
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