Phoxim pour-on agent and preparation method thereof

Abstract

The invention discloses a phoxim pour-on agent and a preparation method thereof. The phoxim pour-on agent comprises the following components in percentages by mass: a, 1.00-40.00% of phoxim; b, 0.10-1.00% of ivermectin; c, 0.50-2.00% of azone; d, 0.05-0.10% of antimicrobial drug; e, 0.01-0.05% of local analgesic; f, 0.50-1.00% of non-steroidal anti-inflammatory drug; and g, the balance of a solvent. The treatment steps are simplified, and the treatment effect and the treatment cost performance are improved.

Description

technical field [0001] The invention belongs to antiparasitic drugs for external use on animals, and in particular relates to a phoxim pour-on and a preparation method thereof. Background technique [0002] Phoxim is an organophosphorus insecticide, which has the characteristics of high efficiency, low toxicity, broad spectrum, and long residual insecticidal effect. It has strong contact and stomach poisoning effects on pests, and can treat various ectoparasitic diseases of livestock, such as Psoriasis, sheep mange, swine scabies, mange, etc.; can also kill mosquitoes, flies, ticks, lice, bedbugs, cockroaches, etc. in the surrounding environment. There is a certain toxicity. [0003] Ivermectin is a semi-synthetic macrolide insecticide, and its insecticidal mechanism is to increase the release of the pest inhibitory transmitter γ-aminobutyric acid (GABA), and to open the Cl ion channel controlled by glutamic acid, enhancing The permeability of the neural membrane to Cl ion...

AI Technical Summary

Problems solved by technology

[0003] Ivermectin is a semi-synthetic macrolide insecticide, and its insecticidal mechanism is to increase the release of the pest inhibitory transmitter γ-aminobutyric acid (GABA), and to open the Cl ion channel controlled by glutamic acid, enhancing The permeability of the neural membrane to Cl ions blocks the transmission of nerve signals, causing the muscle cells of the pests to lose their ability to contract, resulting in the death of the insects. This agent has contact killing and stomach poisoning effects, and has high efficiency, low toxicity, and low residue , pollution-free and other characteristics of biological agents, for a variety of pests such as Thysanoptera (thrips, etc.), Lepidoptera (beet armyworm, diamondback moth, cabbage caterpillar, etc.), Diptera (Liriomyza sativae, etc.), Pests of the order Hemiptera (aphids, psyllids, etc.) and mites (tetranychus cinnabarinus, Tetranychus urticae, etc.) have good control effects, and can be used for comprehensive control of the agricultural pest Thrips palmi, but when the agent is used alone , pests are prone to develop resistance, which significantly reduces the cost-effectiveness of control

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