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Iron protein succinate and method for industrially preparing iron protein succinate

A technology of iron protein succinate and protein, applied in the field of medicine, can solve the problems of unstable quality, inability to mass production, uneven color of products and the like

Active Publication Date: 2021-04-30
北京海泰天正医药科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] The preparation process steps of iron protein succinate currently sold on the market include the steps of acylation, iron loading and refining. The crude iron protein succinate prepared is obtained by freeze-drying, but the cost of the freeze-drying process is very high and cannot Large-scale production, the maximum batch can only be about 7kg
In addition, if non-freeze-drying methods are used, the color of the product will be uneven and the quality will be unstable.

Method used

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  • Iron protein succinate and method for industrially preparing iron protein succinate
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  • Iron protein succinate and method for industrially preparing iron protein succinate

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Embodiment 1

[0053] This embodiment is an exemplary method for preparing iron protein succinate, which comprises the following steps:

[0054] 1) Acylation of casein

[0055] Such as figure 1 As shown in the acylation step, add 600kg of purified water to a clean 1000L reactor, start stirring, slowly add 40.0kg of casein, stir evenly, add dropwise 4mol / L sodium hydroxide solution, adjust the pH value to 7.0-9.0, so that The casein is dissolved and filtered. The filtrate was placed in another clean 1000L reaction kettle, and 16.0kg (0.4 equivalent) of succinic anhydride was slowly added in several times under temperature control at 20-30°C, and 4mol / L sodium hydroxide solution was added dropwise to maintain the pH of the reaction system at 8.0 -8.5, continue to stir for 1.0h after the addition, and filter. The filtrate was placed in a clean 1000L reaction kettle, and 12% hydrochloric acid solution was added dropwise under stirring condition to adjust the pH value at 2.0-2.5 to precipitate...

Embodiment 2

[0076] Except that the acetone of step 5) in the preparation method of embodiment 1 is ethanol, other specific preparation steps are identical with embodiment 1. The results of the determination of iron protein succinate prepared in this example are shown in Table 2.

[0077] Table 2 - Determination of iron protein succinate

[0078]

[0079]

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Abstract

The invention discloses ferric protein succinate and a method for industrially preparing ferric protein succinate. The preparation method of the present invention includes (1) a first washing step, which includes washing the iron protein succinate solid with a first liquid, and then separating to obtain a first precipitate; (2) a second washing step, which includes washing with the second liquid and (3) a drying step, drying the second precipitate at 25-45° C. to a water content of less than 5%. Wherein, the first liquid and the second liquid are respectively iron protein succinate insoluble liquids, and the first liquid and the second liquid are mutually soluble, and the boiling point of the second liquid is lower than that of the first liquid. The preparation method of the present invention can satisfy the industrialized mass preparation of iron protein succinate, and at the same time reduce the process cost.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to iron protein succinate, especially to a method for industrially preparing iron protein succinate. Background technique [0002] Anemia refers to the pathological phenomenon in which the number of red blood cells or hemoglobin in the circulating blood is lower than the normal value for a long time. Anemia is generally divided into three categories: iron deficiency anemia, megaloblastic anemia, and aplastic anemia. Iron deficiency anemia is mainly caused by loss of blood or insufficient absorption of iron. Iron protein succinate (IPS) is a polypeptide protein iron supplement drug, which is a product obtained by complexing casein with ferric chloride after acylation with succinic anhydride. It is an organic iron compound and is used for the treatment of All kinds of iron-deficiency anemia were developed in 1987 by the Italian panmark pharmaceutical company, successfully launched ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C07K14/47C07K1/30
CPCC07K14/4732
Inventor 马永雷霆曾超迟莹
Owner 北京海泰天正医药科技有限公司
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