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Application of manidipine combined temozolomide and pharmaceutical composition thereof in preparation of drug for treating brain glioma

A technology for temozolomide and glioma, which is applied in the field of drug therapy and can solve the problems that the effect of glioma has not been reported.

Inactive Publication Date: 2020-04-07
SUZHOU QINGYA QIRUI BIOTECHNOLOGY CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0006] So far, manidipine has not been reported to enhan

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  • Application of manidipine combined temozolomide and pharmaceutical composition thereof in preparation of drug for treating brain glioma
  • Application of manidipine combined temozolomide and pharmaceutical composition thereof in preparation of drug for treating brain glioma

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Abstract

The invention discloses application of manidipine combined temozolomide and a pharmaceutical composition thereof in preparation of a drug for treating brain glioma. The manidipine combined temozolomide can obviously enhance the treatment effect of temozolomide on brain glioma and helps reduce the dosage of temozolomide, thus providing a new treatment scheme for treatment of brain glioma.

Description

technical field [0001] The invention relates to the field of drug therapeutics, in particular to the application of manidipine in combination with temozolomide and its drug combination in the preparation of drugs for treating brain glioma. Background technique [0002] Malignant glioma is currently the most common brain tumor. It not only has a high incidence rate, but also has a low cure rate. It has the characteristics of high mortality and high infiltration, and poses a great threat to human health. Because it is often interlaced with normal brain tissue, surgical resection often cannot completely eradicate it, which brings great resistance to the clinical treatment of patients. Studies have shown that even after surgery, radiotherapy and chemotherapy, the survival period of patients with malignant glioma is only 12-15 months, and the five-year survival rate is only about 2%; Relapse, the survival time from the first relapse to the patient's death is about 7 months. At ...

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Application Information

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IPC IPC(8): A61K31/496A61K31/4188A61P35/00A61P25/00
CPCA61K31/496A61K31/4188A61P35/00A61P25/00
Inventor 朱志远刘聪聪刘军
Owner SUZHOU QINGYA QIRUI BIOTECHNOLOGY CO LTD
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