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Slimming nano-liposome and preparation method and application thereof

A nano-liposome and slimming technology, which is applied in the direction of pharmaceutical formulations, cosmetic preparations, dressing preparations, etc., can solve the problems of loss of activity and difficulty in achieving slimming effects, so as to promote fat decomposition and promote skin microbiology. Circulation, the effect of inhibiting the differentiation of fat cells

Inactive Publication Date: 2020-04-17
苏州绿叶日用品有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] Traditional slimming cosmetics are to add some functional plant extracts into the micro-emulsion system or water, which is easy to lose activity due to changes in the external environment (light, oxygen, temperature, pH, etc.), even stable functional plant extracts are very It is difficult to penetrate the thick epidermis and dermis, and act on the adipose tissue below it, so it is difficult to achieve the desired slimming effect

Method used

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  • Slimming nano-liposome and preparation method and application thereof
  • Slimming nano-liposome and preparation method and application thereof
  • Slimming nano-liposome and preparation method and application thereof

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preparation example Construction

[0025] The preparation method among the present invention, comprises the steps:

[0026] 1) Mix the polyol and water, heat and stir evenly to obtain a water phase mixture;

[0027] 2) mixing phospholipids, sterols and emulsifiers, stirring and heating until the solid materials are completely melted to obtain an oil phase mixture;

[0028] 3) Add the oil phase mixture in the step 2) to the water phase mixture in the step 1), then add the slimming functional ingredients, and then homogenize at a high speed to obtain a micron emulsion;

[0029] 4) The micro-emulsion in the step 3) is subjected to multiple high-pressure (300-1200 bar) homogenization or high-speed micro-jet treatments to obtain a nano-emulsion with a particle size of 10-500 nm.

Embodiment 1

[0031] The slimming nano liposome of the present embodiment is made up of each component of following parts by weight:

[0032] Slimming ingredients: 0.50 parts of TEA salt of hydroiodic acid, 1.00 parts of poppy poppy extract, 1.00 parts of xanthine, 2.00 parts of sugar isomers, 4.00 parts of artichoke leaf extract; phospholipid: glycerophosphocholine 2.00 parts, dipalmitoylphosphatidylcholine 3.00 parts; sterol: cholesterol 2.00 parts, dihydrocholesterol 2.00 parts; emulsifier: PEG-20 methyl glucose sesquistearate 2.00 parts, PEG-40 hydrogenated 3.00 parts of castor oil; polyols: 10.00 parts of butylene glycol, 3.00 parts of decanediol; 64.50 parts of water.

Embodiment 2

[0034] The slimming nano liposome of the present embodiment is made up of each component of following parts by weight:

[0035] Slimming ingredients: 5.00 parts of bitter orange blossom extract, 20.00 parts of Bacillus / soybean fermentation product extract, 5.00 parts of lotus leaf extract; phospholipids: 6.00 parts of distearoylphosphatidylcholine, 4.00 parts of soybean lecithin; Sterol: 0.10 parts of dihydrocholesterol; emulsifier: 1.00 parts of polyglycerol-10 laurate; polyol: 2.00 parts of 1,2-pentanediol; 66.90 parts of water.

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Abstract

The invention discloses a slimming nano-liposome and a preparation method thereof, and belongs to the technical field of special cosmetics. The slimming nano-liposome is prepared from the following components in parts by weight: 0.10 to 30.00 parts of a slimming functional component, 1.00 to 10.00 parts of phospholipid, 0.10 to 5.00 parts of sterol, 1.00 to 10.00 parts of an emulsifier, 2.00 to 30.00 parts of polyhydric alcohol and the balance of water, totaling 100 parts. By directly or indirectly promoting lipolysis, inhibiting adipocyte differentiation, inhibiting intake of free fatty acidin adipocytes and synthesis of triglyceride, skin microcirculation is promoted. Therefore, the number and the volume of fat cells are reduced, and the slimming functional component for inhibiting andeliminating fat accumulation is loaded in the nano-liposome with the particle size of 10-500nm. The slimming nano-liposome has the characteristics of good stability, high safety (without hormone), targeted slow release, synergistic interaction, good transdermal absorption, long residence time, high bioavailability and the like, and thus, has a relatively ideal slimming effect.

Description

technical field [0001] The invention belongs to the field of functional cosmetics, and in particular relates to a slimming nano liposome and a preparation method thereof. Background technique [0002] With the continuous improvement of people's living standards, there are more and more obese people. The root cause of obesity is that energy intake exceeds energy consumption. When the body eats more calories than it consumes, the excess calories are stored in the body in the form of fat, and when it reaches a certain value, it becomes obese. Obesity not only affects the appearance and mental health of obese people, but also can lead to many diseases, such as hypertension, hyperlipidemia, arteriosclerosis, fatty liver, diabetes, myocardial infarction, etc. [0003] For obese people, slimming products with different concepts have appeared on the market, such as weight loss with drugs (suppress appetite, increase energy consumption, inhibit digestion and absorption in the intest...

Claims

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Application Information

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IPC IPC(8): A61K8/14A61K8/20A61K8/41A61K8/49A61K8/55A61K8/60A61K8/63A61K8/9789A61K8/99A61P3/04A61Q19/00
CPCA61K8/14A61K8/20A61K8/9789A61K8/4953A61K8/60A61K8/553A61K8/63A61Q19/00A61P3/04A61K8/99A61K8/416A61K2800/85
Inventor 孙晋喜刘晓微刘冬
Owner 苏州绿叶日用品有限公司
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