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Periodontal antibacterial and anti-inflammatory gel for implanted teeth and a preparation method thereof

An antibacterial, anti-inflammatory and dental implant technology, applied in the digestive system, pharmaceutical formulations, medical preparations with inactive ingredients, etc., can solve problems such as periodontal inflammation and dental implant failure, and achieve white color, high production efficiency, absorption quick effect

Pending Publication Date: 2020-05-01
JIANGYIN JINTAIKE BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Dental implants are more and more accepted by people because of their beautiful appearance, good strength, and long maintenance time. However, there is a risk in dental implants, that is, periodontal inflammation is prone to occur due to certain damage to surrounding tissues after dental implants. Serious It even leads to the failure of dental implants. With the popularization of medicine, people are more and more aware of the importance of periodontal health to human health. However, there is no drug on the market to prevent periodontal inflammation after dental implant surgery.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0023] The preparation method of above-mentioned gel comprises the following steps:

[0024] 1) Prepare the raw materials according to the quantity; first measure 8-12 parts of glycerin into the mortar, weigh 0.5-1 parts of carbomer into the glycerin, stir, then add 8-12 parts of water, weigh 0.03-0.07 Put 1 part of sodium hyaluronate into a mortar and stir to fully dissolve the carbomer and sodium hyaluronate to obtain gel 1;

[0025] 2) Take another 0.05-0.2 part of chlorhexidine acetate into the beaker, add 0.5-1 part of solubilizer, let chlorhexidine acetate pre-disperse in the solubilizer, then add 0.5-1 part of triethanolamine, stir Further dissolve chlorhexidine acetate to obtain solution 1; in this step, while dissolving chlorhexidine acetate, the solvent of carbomer is also substituted, so that chlorhexidine acetate is better compatible with carbomer in the future , so that the subsequent full dissolution can be better realized;

[0026] 3) Add 0.5-1 part of trietha...

Embodiment 1

[0031] The raw material formula of the gel is: glycerin 10ml, carbomer 0.8g, water 15ml, sodium hyaluronate 0.05g, chlorhexidine acetate 0.1g, solubilizer 1ml, emulsifier 1.5ml, absolute ethanol 10ml.

[0032] The sodium hyaluronate is hyaluronic acid.

[0033] Described emulsifier is triethanolamine.

[0034] The preparation method of described gel is:

[0035] 1) First, measure 10ml of glycerin into the mortar, weigh 0.8g of carbomer into the glycerin, stir, then add 10ml of water, weigh 0.05g of sodium hyaluronate into the mortar, stir to make the carbomer and Sodium hyaluronate is fully dissolved to obtain gel 1;

[0036] 2) Weigh 0.1g chlorhexidine acetate into a beaker, add 500ul solubilizer to pre-disperse chlorhexidine, 750ul triethanolamine, stir to dissolve chlorhexidine, and obtain solution 1;

[0037] 3) Add 750ul triethanolamine and 500ul solubilizer to gel 1, stir well to get gel 2;

[0038] 4) Add the dissolved chlorhexidine acetate in solution 1 to gel 2, s...

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Abstract

The invention discloses periodontal antibacterial and anti-inflammatory gel for implanted teeth and a preparation method thereof. The periodontal antibacterial and anti-inflammatory gel has a formulacomprising the following raw materials in parts by mass: 8-12 parts of glycerinum, 0.5-1 part of carbomer, 12-18 parts of water, 0.03-0.07 part of sodium hyaluronate, 0.05-0.2 part of chlorhexidine acetate, 0.5-2 parts of a solubilizer. 1-2 parts of an emulsifier and 7-13 parts of absolute ethyl alcohol. The periodontal antibacterial and anti-inflammatory gel for implanted teeth has the followingadvantages: the formula is ingenious; good viscosity and quick absorption are realized by addition of the carbomer; by addition of the sodium hyaluronate, cell growth repair is promoted, and inflammation is diminished; traditional chlorhexidine acetate is matched for antisepsis and anti-inflammation; through cooperation of the carbomer, the sodium hyaluronate and the chlorhexidine acetate, a remarkable prevention effect is exerted on periodontitis; in order to prevent periodontitis after dental implantation, the gel only needs to be coated onto the periodontium after dental implantation is completed; and the gel is good in medicine viscosity, quick to absorb, short in stirring time during production, high in production efficiency, white and transparent in finished product color, capable ofbeing stored for a long time, extremely high in practicability, extremely good in economic benefits and social benefits and worthy of popularization.

Description

technical field [0001] The invention belongs to the field of oral health medicine, and in particular relates to an antibacterial and anti-inflammatory gel for periodontal implants and a preparation method thereof. Background technique [0002] With the development of technology, the restoration of tooth decay is becoming more and more thorough. Dental implants are more and more accepted by people because of their beautiful appearance, good strength, and long maintenance time. However, there is a risk in dental implants, that is, periodontal inflammation is prone to occur due to certain damage to surrounding tissues after dental implants. Serious It even leads to the failure of dental implants. With the popularization of medicine, people are more and more aware of the importance of periodontal health to human health. However, there is no drug on the market to prevent periodontal inflammation after dental implant surgery is completed. Contents of the invention [0003] The ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/728A61K31/155A61K9/06A61K47/32A61P1/02
CPCA61K31/728A61K31/155A61K9/06A61K9/0063A61K47/32A61P1/02A61K2300/00
Inventor 张杰徐涛许钦
Owner JIANGYIN JINTAIKE BIOTECH
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