A photoflash thermal analysis-delayed purge injection method for the detection of drug mixtures

A mixture and thermal desorption technology, applied in analytical materials, measurement devices, sample introduction/extraction, etc., to achieve the effect of increasing saturated vapor pressure, improving detection sensitivity, and low power consumption

Active Publication Date: 2021-01-26
DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0011] The object of the present invention is to provide a kind of fast simultaneous detection method that solves volatile and difficult volatile drug mixture

Method used

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  • A photoflash thermal analysis-delayed purge injection method for the detection of drug mixtures
  • A photoflash thermal analysis-delayed purge injection method for the detection of drug mixtures
  • A photoflash thermal analysis-delayed purge injection method for the detection of drug mixtures

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Experimental program
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Effect test

Embodiment 1

[0055] The above method is applied, the sample is passed through a 1μL injection needle, and 1μg / mL narcotine is spotted on the tetrafluorocloth, the absolute mass is 1ng, and then the tetrafluorocloth is inserted into the figure 1 in the device shown. image 3 The ion trap mass spectrum of 1ng remifentanil was obtained by using halogen lamp flash analysis-delayed purge injection. The halogen lamp flash time is 2s, and the intensity can reach about 400.

[0056] Figure 4 Also using the same method, the ion trap mass spectrum of 1ng narcotine obtained by halogen lamp flash analysis-delayed purge injection, the halogen lamp flash time is 2s, and the intensity can reach about 400.

Embodiment 2

[0058] Above-mentioned method is applied, has prepared the mixture of 10 kinds of drugs with different boiling points, and table 1 is their absolute mass and molecular weight, Figure 5 It is the mixture of these ten kinds of drugs with different boiling points that adopts halogen light flash heat analysis-delayed purging when the detection results are inserted into the peek cavity with polyethylene tetrafluorocloth, which is the working sequence figure 2 The change of time in step (5). It can be seen that ten kinds of drug mixtures can be detected at the same time starting from 0s, and these ten kinds of drugs have a higher intensity from 0s to 3s, which realizes the simultaneous detection of a variety of difficult and volatile drug mixtures purpose of designation.

[0059] Table 1 Ten drug mixtures

[0060]

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Abstract

The invention discloses a light flash thermal analysis-delay purging sample introduction method for rapid and simultaneous detection of volatile and low-volatile drug mixtures. There are many types of drugs with large differences in structure and molecular weight, and some of them are difficult to volatile drugs. They will reduce the sensitivity of drug detection instruments that use thermal analysis to inject samples, and at the same time affect the detection and identification efficiency of opium or new psychoactive drug mixtures. The present invention solves the problem of rapid and simultaneous detection of volatile-refractory drug mixtures. The analysis method uses a halogen lamp to perform "flash heat" to rapidly heat up the drug mixture and increase the vapor pressure of the mixed sample, thereby increasing the atmospheric pressure. The ionization efficiency increases the signal intensity of less volatile samples in the mixture by more than an order of magnitude. Combined with the time-delay purging device, the difficult-to-volatile and volatile substances volatilized during the flash heat are purged into the ionization chamber at the same time, which reduces the loss of samples during the continuous purging and heating process, and realizes the difficult-to-volatile and volatile substances. Simultaneous detection of both.

Description

technical field [0001] The invention relates to a mass spectrometry instrument, which essentially uses a halogen lamp to simultaneously heat the mixture of volatile and refractory drugs, which can greatly increase the saturated vapor pressure of refractory drugs in the drug mixture, thereby improving its ionization efficiency and making difficult The signal intensity of volatile samples increased by more than an order of magnitude. The installed delay purge device realizes that the hard-to-volatilize and volatile drugs volatilized during the flash heat are purged into the ionization chamber at the same time, which reduces the purge loss of the sample during the continuous purge heating process. Background technique [0002] Common instrumental analysis methods for mixtures are mainly a certain pretreatment method combined with chromatographic separation technology. Chromatographic techniques mainly include gas chromatography (GC) and liquid chromatography (LC). In order to ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): H01J49/04H01J49/00G01N27/64
CPCG01N27/64H01J49/0031H01J49/0459H01J49/049
Inventor 李海洋侯可勇王伟民王爽
Owner DALIAN INST OF CHEM PHYSICS CHINESE ACAD OF SCI
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