A photoflash thermal analysis-delayed purge injection method for the detection of drug mixtures

Abstract

The invention discloses a light flash thermal analysis-delay purging sample introduction method for rapid and simultaneous detection of volatile and low-volatile drug mixtures. There are many types of drugs with large differences in structure and molecular weight, and some of them are difficult to volatile drugs. They will reduce the sensitivity of drug detection instruments that use thermal analysis to inject samples, and at the same time affect the detection and identification efficiency of opium or new psychoactive drug mixtures. The present invention solves the problem of rapid and simultaneous detection of volatile-refractory drug mixtures. The analysis method uses a halogen lamp to perform "flash heat" to rapidly heat up the drug mixture and increase the vapor pressure of the mixed sample, thereby increasing the atmospheric pressure. The ionization efficiency increases the signal intensity of less volatile samples in the mixture by more than an order of magnitude. Combined with the time-delay purging device, the difficult-to-volatile and volatile substances volatilized during the flash heat are purged into the ionization chamber at the same time, which reduces the loss of samples during the continuous purging and heating process, and realizes the difficult-to-volatile and volatile substances. Simultaneous detection of both.

Description

technical field

[0001] The invention relates to a mass spectrometry instrument, which essentially uses a halogen lamp to simultaneously heat the mixture of volatile and refractory drugs, which can greatly increase the saturated vapor pressure of refractory drugs in the drug mixture, thereby improving its ionization efficiency and making difficult The signal intensity of volatile samples increased by more than an order of magnitude. The installed delay purge device realizes that the hard-to-volatilize and volatile drugs volatilized during the flash heat are purged into the ionization chamber at the same time, which reduces the purge loss of the sample during the continuous purge heating process. Background technique

[0002] Common instrumental analysis methods for mixtures are mainly a certain pretreatment method combined with chromatographic separation technology. Chromatographic techniques mainly include gas chromatography (GC) and liquid chromatography (LC). In order to ...

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