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Trimetazidine hydrochloride controlled release tablet and preparation method therefor

A technology of trimetazidine hydrochloride and controlled-release tablets, which is applied in the field of medicine and can solve the problems of ineffective prevention of myocardial ischemia and limited coverage time

Inactive Publication Date: 2020-05-12
HENAN TIANSHENG TAIFENG PHARM TECH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the limited duration of coverage of traditional anti-angina pectoris drugs, most of them form a window period in the early morning and cannot effectively prevent the occurrence of myocardial ischemia. disease is extremely important

Method used

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  • Trimetazidine hydrochloride controlled release tablet and preparation method therefor
  • Trimetazidine hydrochloride controlled release tablet and preparation method therefor
  • Trimetazidine hydrochloride controlled release tablet and preparation method therefor

Examples

Experimental program
Comparison scheme
Effect test

Embodiment Construction

[0024] Specific implementation examples

[0025] The following implementation examples only illustrate the present invention in further detail, but do not constitute any limitation to the present invention.

[0026] 1. Tablet core prescription design

[0027] Table 1 Core formulation design of trimetazidine hydrochloride controlled-release tablets

[0028] a.

[0029]

[0030] b. Screening: the materials used in the above experiment were respectively passed through a 100-mesh sieve.

[0031] c. Weighing: Weigh the prescribed amount of materials respectively. Dissolve povidone k30 in water at room temperature and stir to form a transparent solution.

[0032] d. Granulation: Mix the materials in each recipe evenly, add povidone k30 solution to prepare soft materials, pass through a 30-mesh sieve, and make wet granules.

[0033] e. Drying: heat the wet granules in an oven at 50°C, and control the water content to 1-3%.

[0034] f. Grain sizing: the dry granules pass thro...

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PUM

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Abstract

The invention relates to a trimetazidine hydrochloride controlled release tablet and a preparation method therefor. According to the trimetazidine hydrochloride controlled release tablet, hydroxypropyl methylcellulose is employed as a controlled release matrix material, and a microporous membrane coating technique is employed; the drug passes through a microporous semipermeable membrane by means of osmotic pressure, and sustainably releases at a constant rate, and stable drug therapeutic concentration can be kept, so that a therapeutic effect can be kept for about 24 hours only by performing administration once a day. By using the controlled release tablet, not only can the drug use time be reduced, but also the therapeutic effect can be improved and prolonged, and side reactions are reduced; and nocturnal angina can also be prevented, and the compliance and the safety of taking the drug by a patient are improved.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the preparation of trimetazidine hydrochloride controlled-release tablets. Background technique [0002] Trimetazidine hydrochloride is the first drug that acts on the metabolism of cardiomyocytes. It balances the metabolism by inhibiting fatty acid oxidation and stimulating glucose oxidation, and protects the myocardium; it protects the contraction function of cells and limits oxygen free radicals. Membrane protection; ensure the normal operation of ATP, ensure the normal operation of ion pumps and transmembrane sodium-potassium flow, and stabilize the intracellular environment; increase coronary blood flow, improve the balance between supply and demand of myocardial oxygen, and play a protective role in the myocardium. The study also found that the drug does not affect hemodynamics and has no negative inotropic effect. [0003] Trimetazidine hydrochloride is clini...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/36A61K9/22A61K47/38A61K47/10A61K31/495A61P9/10
CPCA61K9/2054A61K9/2059A61K9/2853A61K9/2866A61K31/495A61P9/10
Inventor 沙薇梁建华李晨希
Owner HENAN TIANSHENG TAIFENG PHARM TECH CO LTD
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