Composition for preventing and treating hyperuricemia and gout and preparation method and application thereof

Abstract

The invention discloses a composition for preventing and treating hyperuricemia and gout and a preparation method and application thereof, and belongs to the field of traditional Chinese medicines. The composition for preventing and treating hyperuricemia and gout comprises the following raw materials: glabrous greenbrier rhizome, plantain herb, prepared rhubarb root and rhizome, radix achyranthisbidentatae and fragrant solomonseal rhizome. According to the invention, the glabrous greenbrier rhizome with effects of resolving dampness and purging turbidity is used as a monarch drug, the plantain herb with effects of dispelling dampness and promoting diuresis for assisting the glabrous greenbrier rhizome with the effects of resolving dampness and purging turbidity is used as a minister drug, the prepared rhubarb root and rhizome with effects of clearing hollow viscera and removing blood stasis is used as an assistant drug, and the radix achyranthis bidentatae with effects of removing blood stasis and guiding medicines downward and the fragrant solomonseal rhizome with effects of moistening stomach and coordinating the drug actions of a prescription are used as envoy drugs, so that the composition has the effects of resolving dampness and purging turbidity and clearing hollow viscera and removing blood stasis, which is beneficial to the discharge of uric acid from the urethra through the kidney and the excretion of uric acid from the intestinal tract, thus the composition has the pharmacological actions of remarkably reducing blood uric acid and accelerating uric acid discharge. The composition with "homology of medicine and food" can be prepared into various preparations such as capsules, granules and oral liquid, and is capable of being taken for a long time, free of toxic or side effect and wide in applicable population.

Description

technical field [0001] The invention relates to the field of traditional Chinese medicine, in particular to a composition for preventing and treating hyperuricemia and gout and a preparation method thereof. Background technique [0002] Hyperuricemia (HUA) has a high incidence and great harm, and currently there is no ideal drug treatment. At present, there are about 170 million HUA patients in my country, and the incidence is increasing year by year and younger. The highest solubility of uric acid in the blood is 420 μmol / L. If it exceeds this value, urate is easily precipitated and crystallized and deposited in the joints, causing gouty arthritis. . HUA can not only cause gout, but also an independent risk factor for metabolic syndrome, type II diabetes, hypertension, coronary heart disease, chronic kidney disease and other diseases. [0003] Intestinal juice is an important source of uric acid, and the intestine is an important organ for reducing uric acid. Studies have...

AI Technical Summary

Problems solved by technology

[0004] The current drugs for the treatment of HUA include probenecid, benzbromarone (to promote the excretion of uric acid) and allopurinol (to inhibit the production of uric acid), but these drugs have many adverse reactions, such as gastrointestinal toxicity, allergic reactions, liver Kidney damage, etc., are not suitable for long-term use; HUA requires long-term management, and its treatment course is generally three months or more. There is an urgent need for new Chinese medicines that have significant curative effects, fewer adverse reactions, and are less likely to relapse after drug withdrawal to be used in clinical practice.