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Method for enriching and purifying folic acid in herba orostachyos by utilizing macroporous adsorption resin

A technology of pore adsorption and resin, which is applied in the field of enrichment and purification of folic acid and folic acid in Vasong by using macroporous adsorption resin. Convenient and fast effect

Inactive Publication Date: 2020-05-26
HUANGGANG HUAYANG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] The purpose of the present invention is to overcome the shortcomings of conventional techniques such as relatively low extraction rate and low extraction purity, and provide a method for enriching and purifying folic acid in Vasong by using macroporous adsorption resin

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Embodiment 1: a kind of method utilizing macroporous adsorption resin to enrich and purify folic acid in Vasong, its steps are as follows:

[0027] (1) After crushing the dried pine, pass through a 60-mesh sieve, heat and reflux extraction with pH=4 acid water at a ratio of material:water=1:12 for 2 hours each time, and combine the extracts;

[0028] (2) Filtrate the vasone extract treated in (1), and dry under reduced pressure to obtain the initial extract in the form of an extract;

[0029] (3) dissolving the harvested extract in 75% ethanol for decolorization, and concentrating the decolorization solution to recover ethanol to obtain a crude extract of folic acid.

[0030] (4) The obtained folic acid extract is adsorbed on a macroporous adsorption resin chromatography column, and the macroporous resin used is the NKA-II type resin produced by Tianjin Nankai University;

[0031] (5) Use 10%, 20%, 30%, 40%, 50%|, 60%, 70%, 80%|, 90%, 95% ethanol to carry out gradient ...

Embodiment example 2

[0035] Implementation case 2: a kind of method utilizing macroporous adsorption resin to enrich and purify ursolic acid in cabbage, its steps are as follows:

[0036] (1) After crushing the dried vegetables, pass through a 10-mesh sieve, heat and reflux extraction with pH=4 acid water at a ratio of material:water=1:12 for 2 hours each time, and combine the extracts;

[0037] (2) Filtrate the vasone extract treated in (1), and dry under reduced pressure to obtain the initial extract in the form of an extract;

[0038] (3) dissolving the harvested extract in 75% ethanol for decolorization, and concentrating the decolorization solution to recover ethanol to obtain a crude extract of folic acid.

[0039] (4) The obtained folic acid crude extract is adsorbed with a macroporous adsorption resin, and the macroporous resin used is the D4006 type resin produced by Tianjin Nankai University;

[0040] (5) Carry out elution with 10%, 30%, 50%, 70%, 90% ethanol in macroporous adsorbent re...

Embodiment example 3

[0044] Implementation Case 3: A method for enriching and purifying folic acid in Vasong by using macroporous adsorption resin, the steps are as follows:

[0045] (1) After crushing the dried pine, pass it through an 80-mesh sieve, heat and reflux extraction with pH=4 acid water at a ratio of material:water=1:12, and extract twice for 2 hours each time, and combine the extracts;

[0046] (2) Filtrate the vasone extract treated in (1), and dry under reduced pressure to obtain the initial extract in the form of an extract;

[0047] (3) dissolving the harvested extract in 75% ethanol for decolorization, and concentrating the decolorization solution to recover ethanol to obtain a crude extract of folic acid.

[0048] (4) the obtained folic acid crude extract is adsorbed on a macroporous adsorption resin chromatography column, and the macroporous resin used is the NKA-9 type resin produced by Tianjin Nankai University;

[0049](5) Carry out gradient elution successively in macropor...

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Abstract

The invention belongs to the field of natural organic chemistry, and relates to a method for enriching and purifying folic acid in herba orostachyos by utilizing macroporous adsorption resin. The method is characterized in that a macroporous adsorption technology is used for separating and purifying folic acid, the adsorption selectivity on folic acid is good, adsorption and desorption are fast, and the adsorption capacity is large; extraction is convenient and fast, raw material sources are rich, production cost is low, separation effect is obvious, extraction purity is high, a folic acid semi-finished product with the content of more than 35% and a folic acid final product with the content of more than 98% can be obtained, and the defects of relatively low conventional extraction rate and low extraction purity are overcome. Macroporous adsorption resin with stable physicochemical properties, large surface area, high exchange speed, high mechanical strength, strong anti-pollution ability and good thermal stability is selected, folic acid can be selectively adsorbed from a solution through physical adsorption, adsorption is fast, desorption is fast, and adsorption capacity is large.

Description

technical field [0001] The invention belongs to the field of natural organic chemistry and relates to a method for purifying folic acid, in particular to a method for enriching and purifying folic acid in vapine by using a macroporous adsorption resin. Background technique [0002] Vasong: Chinese herbal medicine, [synonym] yesterday leaf lotus grass ("Tang Materia Medica"), rootless grass on the house ("Experience and Good Prescription"), Xiangtian grass ("Gengxin Jade Book"), tile flower ("Zaiyuan "Prescription"), stone lotus, lotus ("Fujian folk herbal medicine"), dry dripping ("Northeast medicine plant records"), cat's head grass, vata ("Hebei medicinal materials"), canopy grass ("Handbook of Chinese herbal medicines") "), tile frost, tile onion ("Sichuan Traditional Chinese Medicine"), sour tower, tasong, rabbit crutches, dry hanging soft-shelled turtle, stone tower flower, wolf's claw, sour liu ("Liaoning Economic Flora"), tile pagoda, tile lotus , Yansong, house pine...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D475/04
CPCC07D475/04
Inventor 张龑
Owner HUANGGANG HUAYANG PHARMA
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