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A kind of oxidized polysaccharide anticoagulant coating hemodialysis membrane material and preparation method thereof

A technology of hemodialysis and oxidized polysaccharide, applied in the field of hemodialysis membrane materials, can solve the problems of safety hazards such as carrying animal allergens or viruses, limiting the application and promotion of heparin coating, and high cost of heparin, and achieving good anticoagulation. Effectiveness with biocompatibility, overcoming abnormal bleeding, and reducing the cost of raw materials for production

Active Publication Date: 2022-02-11
TIANJIN CITY THIRD CENT HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, studies have shown that while heparin has anticoagulant activity, it also has antiplatelet activity, which can cause side effects such as abnormal bleeding, and there are safety hazards such as carrying animal allergens or viruses, and the cost of heparin is relatively high. Both limit the application and promotion of heparin coating to a certain extent

Method used

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  • A kind of oxidized polysaccharide anticoagulant coating hemodialysis membrane material and preparation method thereof
  • A kind of oxidized polysaccharide anticoagulant coating hemodialysis membrane material and preparation method thereof
  • A kind of oxidized polysaccharide anticoagulant coating hemodialysis membrane material and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0028] Example 1: Extraction and purification of Yunzhi polysaccharide

[0029] Take the dried versicolor fruiting bodies, crush them, pass through a 10-20 mesh sieve, add 10 times the weight of distilled water to soak for 4 hours, heat to 90-100°C, extract for 10 hours, filter, discard the residue, concentrate the filtrate, cool to room temperature, and then Adding 10 times the weight of the concentrated solution to 95% ethanol, a white flocculent precipitate was precipitated, left standing for 24 hours, centrifuged, and dried at room temperature to obtain polysaccharides from Yunzhi.

Embodiment 2

[0031] Take the inner surface as 50cm 2 Put the pre-prepared potassium permanganate-50% concentrated sulfuric acid solution into the polypropylene dialysis tubing, acidify the pretreatment for 5 minutes, rinse the dialysis tubing after the acidification treatment with distilled water, and then put 0.05% polyethylene In the amine solution, adjust the pH value to 9, carry out the amination modification reaction at room temperature for 20 minutes, take it out, rinse it with distilled water, and dry it to obtain a surface-modified dialysis tube for use; the Polysaccharide polysaccharide prepared in Example 1 is fully Dissolve in deionized water, prepare 100ml of versicolor polysaccharide aqueous solution with a mass fraction of 2%, add sodium periodate at a molar ratio of 1:10, react for 24 hours under magnetic stirring in the dark, add ethylene glycol to terminate the reaction, and Add 4g NaCl, mix well, pour into absolute ethanol at a volume ratio of 1:5, wait for complete preci...

Embodiment 3

[0033] Take the inner surface as 50cm 2 Put the pre-prepared potassium permanganate-60% concentrated sulfuric acid solution into the polypropylene dialysis tubing, acidify the pretreatment for 5 minutes, rinse the dialysis tubing after the acidification treatment with distilled water, and then put it into 0.10% polyethylene In the amine solution, adjust the pH value to 9, carry out the amination modification reaction at room temperature for 20 minutes, take it out, rinse it with distilled water, and dry it to obtain a surface-modified dialysis tube for use; the Polysaccharide polysaccharide prepared in Example 1 is fully Dissolve in deionized water, prepare 100ml of versicolor polysaccharide aqueous solution with a mass fraction of 2%, add sodium periodate at a molar ratio of 1:10, react for 24 hours under magnetic stirring in the dark, add ethylene glycol to terminate the reaction, and Add 4g NaCl, mix well, pour into absolute ethanol at a volume ratio of 1:5, wait for comple...

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Abstract

The invention relates to a preparation method of a hemodialysis membrane material, which comprises the following steps: (1) taking a part of the dialysis pipeline, putting it into potassium permanganate concentrated sulfuric acid solution, and performing acidification pretreatment; The pipeline is put into a polyethyleneimine solution for amination modification reaction to obtain a surface-modified dialysis pipeline; (3) adding the polysaccharide solution to sodium periodate to react to obtain an oxidized polysaccharide; (4) dissolving the above-mentioned oxidized polysaccharide The solution is poured into the surface-modified dialysis tubing to react to prepare the dialysis tubing membrane material coated with oxidized polysaccharide. The hemodialysis membrane material of the present invention can completely overcome the defects of the existing heparin coating materials that cause abnormal bleeding, avoid safety hazards such as carrying animal allergens or viruses, reduce the cost of production raw materials, and have good anticoagulation blood and biocompatibility.

Description

technical field [0001] The invention relates to the field of biomedical materials, in particular to a hemodialysis membrane material. Background technique [0002] Hemodialysis (HD) is an effective alternative therapy for the treatment of acute and chronic renal failure. It removes harmful substances in the body through diffusion, ultrafiltration, convection, adsorption and other mechanisms, and maintains water and electrolyte balance. However, the biomaterials in contact with blood in hemodialysis will destroy the blood stabilization mechanism, causing a cascade reaction of thrombus and embolism. Toxemia and body temperature changes can trigger complex cascade-like inflammation anyway, causing the release of different biologically active products. Therefore, while meeting the anticoagulant conditions, hemodialysis materials also need to inhibit the activation of the blood inflammatory system, so that improve its biocompatibility. [0003] The traditional hemodialysis syst...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): B01D71/30B01D71/26B01D71/68B01D67/00A61M1/16
CPCB01D71/30B01D71/26B01D71/68B01D67/0006A61M1/1621A61M2202/0413A61M2202/0021
Inventor 李彤高文卿
Owner TIANJIN CITY THIRD CENT HOSPITAL
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